Abstract
Greece is a country of intermediate endemicity for hepatitis B and low endemecity for hepatitis C with a downward trend during the last years. In the present study we investigated the prevalence of hepatitis B virus (HBV) and hepatitis C virus (HCV) infection in the region of South-Western Greece and tried to identify the most important risk factors of transmission. This is a unique epidemiological study, as it is the first community based study in the general population of Greece, with a methodological approach based on multi-staged random sampling. The prevalence of HBV infection seems to be decreasing with a 22.6% rate of HBV markers and a 2.1% rate of chronic HBV carriers. We found male sex, old age and intrafamiliar exposure as the major independent risk factors of HBV transmission, while sexual contact, absence of condom prophylaxis and living in rural areas seem to have also a significant impact for HBV infection. No relation was found between HBV transmission and working in health care facilities, pre-existing hospital admissions and history of transfusion. The prevalence of anti-bodies to the HCV was found 0.5%, even lower than the rate reported in the Mediterranean region. Parenteral exposure was the main risk factor for the transmission of HCV infection.
References
Lee WM. Hepatitis B virus infection. N Eng J Med 1997; 333: 1733–1745.
McQuillan GM, Coleman PJ, Kruszon-Moran D, Moyer LA, Lambert SB, Margolis HS. Prevalence of hepatitis B virus infection in the United States: The National Health and Nutrition Examination surveys, 1976 through 1994. Am J Public Health 1999; 89: 14–18.
Yano M, Yatsuhashi H, Inoue O, Inokuchi K, Koga M. Epidemiology and long term prognosis of hepatitis C virus infection in Japan. Gut 1993; 34(Suppl 2): S13–S16.
Di Bisceglie AM. Hepatitis C. Lancet 1998; 351: 351–355.
Perrillo RP. Hepatitis B: Transmission and natural history. Gut 1993; 34(Suppl 2): S48–S49.
Richard V. Epidemiology of hepatitis C in the world. Med Trop 1996; 56: 393–399.
Lionis C, Frangoulis E, Koulentakis M, Biziaros E, Kouroumalis E. Prevalence of hepatitis A, B and C markers in school children of a rural area in Crete, Greece. Eur J Eridemiol 1997; 13: 417–420.
Lionis C, Koulentaki M, Biziaros E, Kouroumalis E. Current prevalence of hepatitis A, B and C in a well-defined area in rural Crete, Greece. J Viral Hepat 1997; 4: 55–61.
Tsakris A, Kyriakis KP, Chryssou S, Papoutsakis G. Seroprevalence of hepatitis B markers among female and transsexual sex workers in Athens, Greece. Genitourin Med 1997; 73: 223–228.
Malliori M, Sypsa V, Psichogiou M, et al. A survey of bloodborne viruses and associated risk behaviors in Greek prisons. Addiction 1998; 93: 243–251.
Lionis C, Vlachonikolis IG, Skliros S, Symeonidis A, Merkouris BP, Kouroumalis E. Do undefined sources of hepatitis C transmission exist? The Greek study in general practice. J Viral Hepat 2000; 7: 218–224.
Kyriakis KP, Foudoulaki LE, Papoulia EI, Sofroniadou KE. Seroprevalence of hepatitis B surface antigen (HBsAg) among first-time and sporadic blood donors in Greece: 1991-1996. Tranfus Med 2000; 10: 175–180.
Koulentaki M, Spanoudakis S, Kantidaki E, et al. Prevalence of hepatitis B and C markers in volunteer blood donors in Crete. A 5-year study. J Viral Hepat 1999; 6: 243–248.
Stamouli M, Gizaris V, Totos G, Papaevangelou G. Decline of hepatitis B infection in Greece. Eur J Epidemiol 1999; 15: 447–449.
Skliros EA, Sotiropoulos A, Peppas T, Sofroniadou K, Lionis C. High prevalence of HBV infection markers in refugees from Eastern countries. Ital J Gastroenterol Hepat 1999; 31: 84–86.
Dalekos GN, Zervou E, Karabini F, Tsianos EV. Prevalence of viral markers among refugees from Southern Albania: Increased incidence of infection with hepatitis A, B and D viruses. Eur J Gastroenterol Hepatol 1995; 7: 553–558.
Tandon BN, Acharya SK, Tandon A. Epidemiology of hepatitis B virus infection in India. Gut 1996; 38(Suppl 2): S56–S59.
Kiire CF. The epidemiology and prophylaxis of hepatitis B in sub-Saharan Africa: A view from tropical and subtrorical Africa. Gut 1996; 38(Suppl 2): S5–S12.
Alter MJ, Kruszon-Moran D, Nainan OV, et al. The prevalence of hepatitis C virus infection in the United States, 1988 through 1994. N Eng J Med 1999; 341: 556–562.
Alter MG. Epidemiology of hepatitis C in the West. Semin Liver Dis 1995; 15(1): 5–14.
Guadagnino V, Stroffolini T, Rapicetta M, et al. Prevalence, risk factors and genotype distribution of hepatitis C virus infection in the general population: A community-based survey in Southern Italy. Hepatology 1997; 26: 1006–1011.
Trepo C, Bailly F. Magnitude and management of HCV infection in France. Dig Dis Sci 1996; 41(Suppl 12): S22–S26.
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Gogos, C., Fouka, K., Nikiforidis, G. et al. Prevalence of hepatitis B and C virus infection in the general population and selected groups in South-Western Greece. Eur J Epidemiol 18, 551–557 (2003). https://doi.org/10.1023/A:1024698715741
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DOI: https://doi.org/10.1023/A:1024698715741