Abstract
In batch culture for glutathione production with Candida utilis, a higher temperature (30 °C) was required to hasten cell growth while a lower temperature (26 °C) was needed to increase the production of glutathione. A two-stage temperature control strategy was used to enhance both the yield and the productivity of glutathione. As a result, glutathione production was increased by 5% and 23% of that at 26 °C and 30 °C, respectively, and the intracellular glutathione content reached 2.5% (w/w).
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Wei, G., Li, Y., Du, G. et al. Application of a two-stage temperature control strategy for enhanced glutathione production in the batch fermentation by Candida utilis . Biotechnology Letters 25, 887–890 (2003). https://doi.org/10.1023/A:1024034508136
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DOI: https://doi.org/10.1023/A:1024034508136