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Role of Helicobacter pylori Infection in Complications from Meckel's Diverticulum

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Abstract

Our purpose was to evaluate the role of Helicobacter pylori in complications arising from Meckel's diverticulum in the Jewish and Arab populations of Jerusalem. Diverticular tissues were studied by hematoxylin–eosin, Giemsa, and two immunohistochemical stainings. Three groups of patients were identified: (1) 20 patients in whom Meckel's diverticulum was an incidental finding during laparotomy for other causes; (2) 7 patients with heterotopic gastric mucosa who underwent laparotomy because of bleeding from Meckel's diverticulum–-3 were infected with Helicobacter pylori; and (3) 15 patients who underwent operations because of complicated Meckel's diverticulum except for bleeding—7 patients had heterotopic gastric mucosa; only 1 patient had Helicobacter pylori. Demographic, clinical, and pathological findings within the gastric mucosa were not different in patients with and without colonization with Helicobacter pylori. In conclusions, Helicobacter pylori colonizes heterotopic gastric mucosa with Meckel's diverticulum, but probably has a minor role in the complications of Meckel's diverticulum.

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References

  1. Soll AH: Gastric and duodenal and stress ulcer. In Gastrointestinal Disease, 5th ed. MH Sleisenger, JS Fordtran (eds). Philadelphia, Saunders, 1993, pp 580-679

    Google Scholar 

  2. Wyatt JI, Rathbone BJ, Dixon MF, et al: Campylobacter pyloriditis and acid induced gastric metaplasia in the pathogenesis of duodenitis. J Clin Pathol 40:841-848, 1987

    Google Scholar 

  3. Talley NJ, Cameron AJ, Shorter RG, et al: Campylobacter pylori and Barrett's esophagus. Mayo Clin Proc 63:1176-1180, 1988

    Google Scholar 

  4. Dye KR, Marshall BJ, Frierson HF, et al: Campylobacter pylori in heterotopic gastric tissue in the rectum. Am J Clin Pathol 93:144-147, 1990

    Google Scholar 

  5. Trier JS, Winter HS: Anatomy, embryology and developmental abnormalities of the small intestine and colon. In Gastrointestinal Disease, 5th ed. MH Sleisenger, JS Fordtran (eds). Philadelphia, Saunders, 1993, pp 793-822

    Google Scholar 

  6. De Cothi GA, Newbold KM, O'Connor HJ: Campylobacter-like organisms and heterotopic gastric mucosa in Meckel's diverticula. J Clin Pathol 42:132-134, 1989

    Google Scholar 

  7. Wyatt JI: Campylobacter pylori in Meckel's diverticulum? Presented at the Exerpta Med Int Congr Ser 847:513-516, 1989

    Google Scholar 

  8. Morris A, Nicholson G, Zwi J, et al: Campylobacter pylori infection in Meckel's diverticula containing gastric mucosa. Gut 30:1233-1235, 1989

    Google Scholar 

  9. Stolte M, Lanuer E: Campylobacter pylori heterotopic gastric mucosa in Meckel's diverticulum. Leber Magen Darm 19:209-210, 1989

    Google Scholar 

  10. Bemelman WA, Bosma A, Wiersma PH, et al: Role of Helicobacter pylori in the pathogenesis of complications of Meckel's diverticula. Eur J Surg 159:171-175, 1993

    Google Scholar 

  11. Hill P, Rodes J: Helicobacter pylori in ectopic gastric mucosa in Meckel's diverticulum. Pathology 30:7-9, 1998

    Google Scholar 

  12. Finn LS, Christie DL: Helicobacter pylori and Meckel's diverticula. J Pediatr Gastroenterol Nutr 32:150-155, 2001

    Google Scholar 

  13. Loffeld RJ, Loffeld BC, Arends JW: Campylobacter-like organisms in Meckel's diverticulum? J Clin Pathol 42:1111, 1989

    Google Scholar 

  14. Heatley MK, Arthur K, Maxwell P: CLO in Meckel's diverticulum. J Clin Pathol 43:86-87, 1990

    Google Scholar 

  15. Fich A, Talley NJ, Shorter RG, et al: Does Helicobacter pylori colonize the gastric mucosa of Meckel's diverticulum? Mayo Clin Proc 65:187-191, 1990

    Google Scholar 

  16. Kumar S, Small P, Nawroz I: Helicobacter pylori and Meckel's diverticulum. J R Coll Surg Edinb 36:225-226, 1991

    Google Scholar 

  17. Parikh SS, Ranganathan S, Prabhu SR, et al: Heterotopic gastric mucosa and Helicobacter pylori infection in Meckel's diverticulum in Indian subjects. J Assoc Physicians India 41:647-648, 1993

    Google Scholar 

  18. Maieron R, Stimac D, Avellini C, et al: Acute gastrointestinal bleeding due to Meckel's diverticulum heterotopic gastric mucosa. Ital J Gastroenterol 28:225-228, 1996

    Google Scholar 

  19. Cserni G: Gastric pathology in Meckel's diverticulum. Review of cases resected between 1965 and 1995. Am J Clin Pathol 106:782-785, 1996

    Google Scholar 

  20. Chan GSW, Yuen ST, Chu KM: Helicobacter pylori in Meckel's diverticulum with heterotopic gastric mucosa in a population with relatively high Helicobacter pylori prevalence rate. J Gastroenterol Hepatol 14:313-316, 1999

    Google Scholar 

  21. Dunn BE, Perez-Perez GI, Blaser MJ: Two-dimensional gel electrophoresis and immunoblotting of Campylobacter pylori proteins. Infect immun 57:1825-1833, 1989

    Google Scholar 

  22. Andersen LP, Holck S, Poulsen CO: Campylobacter pylori detected by indirect immunohistochemical technique. APMIS 96:559-564, 1988

    Google Scholar 

  23. Bereswill S, Lichte F, Vey T, et al: Cloning and characterization of the fur gene from Helicobacter pylori. FEMS Microbiol Lett 159:193-200, 1988

    Google Scholar 

  24. Sahay P, West AP, Birkenhead D, et al: Campylobacter jejuni in the stomach. J Med Microbiol 43:75-77, 1995

    Google Scholar 

  25. Novis BH, Gabay G, Naftali T: Helicobacter pylori: The Middle East Scenario. Yale J Biol Med 71:135-141, 1998

    Google Scholar 

  26. Fich A, Carel RS, Keret D, Goldin E: Seroprevalence of Helicobacter pylori in the Israeli Population. Eur J Gastroenterol Hepatol 5:339-341, 1993

    Google Scholar 

  27. Benenson S, Halle D, Rudensky B, Faber J, Schlesinger Y, Branski D, Rabinowitz N, Wilschanski M: Helicobacter pylori genotypes in israeli children: the significance of geography. J Pediatr Gastroenterol Nutr 35:680-684, 2002

    Google Scholar 

  28. Newbold KM, O'Connor HJ: Helicobacter pylori infection in Meckel's diverticula. Gut 31:243, 1994 (letter)

    Google Scholar 

  29. Han SK, Evans DG, EI-Zaatari FAK, et al: The interaction of pH, bile and Helicobacter pylcri may explain duodenal ulcer. Am J Gastroenterol 91:1135-1137, 1996

    Google Scholar 

  30. Parsonnet J, Shmuely H, Haggerty T: Fecal and oral shedding of Helicobacter pylori from healthy infected adults. JAMA 282:2240-2245, 1999

    Google Scholar 

  31. Dore MP, Osato MS, Malaty HM, et al: Characterization of a culture method to recover Helicobacter pylori from the feces of infected patients. Helicobacter 5:165-168, 2000

    Google Scholar 

  32. Mathur S, Verseman S, Estrada R, et al: Bleeding from Meckel's diverticulum after the use of ibuprofen. Am J Gastroenterol 87:1467-1470, 1992

    Google Scholar 

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Authors and Affiliations

  1. Departments of Medicine, Mount Scopus, Hebrew University-Hadassah Medical School, Jerusalem, Israel

    Zvi Ackerman & Patrizia Cohen

  2. Department of Histopathology, Charing Cross Hospital, Imperial College School of Medicine, London, UK

    David Peston

  3. Pathology, Hadassah University Hospital, Mount Scopus, Hebrew University-Hadassah Medical School, Jerusalem, Israel

    Patrizia Cohen

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  1. Zvi Ackerman
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  2. David Peston
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  3. Patrizia Cohen
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Ackerman, Z., Peston, D. & Cohen, P. Role of Helicobacter pylori Infection in Complications from Meckel's Diverticulum. Dig Dis Sci 48, 1068–1072 (2003). https://doi.org/10.1023/A:1023704410208

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