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Interrelation Between Expression of Matrix Metalloproteinase 7 and β-Catenin in Esophageal Cancer

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Abstract

Matrix metalloproteinase 7 (MMP-7) may play a key role in the progression of various human malignant tumors. Nuclear β-catenin enhances the activating expression of MMP-7 genes by binding with the T-cell factor/lymphoid enhancer factor family of transcription factors. We immunohistochemically examined the expression of MMP-7 and β-catenin to better understand the significance of these factors in the progression of esophageal squamous cell carcinoma. The entire coding region of β-catenin exon 3 was also analyzed by direct sequencing in all cases. We found that MMP-7 was expressed in 7 (20.6%) of 34 esophageal squamous cell carcinomas. There was a significant relationship between MMP-7 expression and tumor invasion into adjacent structures (P < 0.05). Aberrant nuclear expression of β-catenin was found in 12 of 34 (35.3%) esophageal cancers and correlated with MMP-7 expression, the statistical difference being (P < 0.05). None of the 34 esophageal cancers examined carried mutations in β-catenin exon 3. MMP-7 expression correlates with penetrating tumor progression in esophageal cancer. Nuclear translocation of β-catenin, without mutations in β-catenin exon 3, is associated with MMP-7 expression.

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Authors and Affiliations

  1. Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, 812-8582, Japan

    Hirohi Saeki, Shinji Tanaka, Keishi Sugimachi, Yasue Kimura, Mitsuhiro Miyazaki, Takefumi Ohga & Keizo Sugimachi

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  1. Hirohi Saeki
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  2. Shinji Tanaka
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  3. Keishi Sugimachi
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  4. Yasue Kimura
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  5. Mitsuhiro Miyazaki
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  6. Takefumi Ohga
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  7. Keizo Sugimachi
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Saeki, H., Tanaka, S., Sugimachi, K. et al. Interrelation Between Expression of Matrix Metalloproteinase 7 and β-Catenin in Esophageal Cancer. Dig Dis Sci 47, 2738–2742 (2002). https://doi.org/10.1023/A:1021057206005

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