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In Vitro Plasma Metabolism of RMP-7

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REFERENCES

  1. T. Inamura, T. Nomura, R. T. Bartus, and K. L. Black. Intracarotid infusions of RMP7, a bradykinin analog: a method for selective drug delivery to brain tumors. J. Neurosurgery, in press.

  2. I. A. Sheikh and A. P. Kaplan. Studies of the digestion of bradykinin, lys-bradykinin, and des-Arg9-bradykinin by angiotensin converting enzyme. Biochem. Pharmac., 35, 1951–1956 (1986).

    Google Scholar 

  3. I. A. Sheikh and A. P. Kaplan. Studies of the digestion of bradykinin, lysyl bradykinin, and kinin-degradation products by carboxypeptidases A, B, and N. Biochem. Pharmac., 35, 1957–1963 (1986).

    Google Scholar 

  4. Y. S. Bakhle. Pulmonary metabolism of bradykinin analogues and the contribution of angiotensin converting enzyme to bradykinin inactivation in isolated lungs. Br. J. Pharmacol., 59, 123–128 (1977).

    Google Scholar 

  5. F. Marceau, M. Gendreau, J. Barabe, S. St.-Pierra, and D.-Regoli. The degradation of bradykinin (BK) and of des-Arg9-BK in plasma. Can. J. Physiol. Pharmacol., 59, 131–138 (1981).

    Google Scholar 

  6. D. A. McCarthy, D. E. Potter and E. D. Nicolaides. An in vivo estimation of the potencies and half-lives of synthetic bradykinin and kallidin. J. Pharmacol. Exp. Ther., 148, 117–122, 1965.

    Google Scholar 

  7. G. Drapeau, N. E. Rhaleb, S. Dion, D. Jukic and D. Regoli. [Phe8(CH2NH)Arg9]bradykinin, a B2 receptor selective agonist which is not broken down by either kininase I or II. Eur. J. Pharmacol., 155, 193–195 (1988).

    Google Scholar 

  8. G. Drapeau, A. Chow, and P. E. Ward. Metabolism of bradykinin by angiotensin I converting enzyme and carboxypeptidase N. Peptides, 12, 631–638 (1991).

    Google Scholar 

  9. J. A. Straub, A. Akiyama, G. Musso, P. Parmar. Limited enzymatic digestion for the determination of the ratio of quantities of minor diastereomeric contaminants in preparations of RMP-7, a peptide containing a reduced peptide bond. (manuscript in preparation)

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  1. Alkermes, Inc, 64 Sidney Street, Cambridge, MA

    Julie Ann Straub, Alan Akiyama & Parul Parmar

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  1. Julie Ann Straub
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  2. Alan Akiyama
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  3. Parul Parmar
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Straub, J.A., Akiyama, A. & Parmar, P. In Vitro Plasma Metabolism of RMP-7. Pharm Res 11, 1673–1676 (1994). https://doi.org/10.1023/A:1018986510570

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