Abstract
Loosening of implants in bone is commonly associated with a development of fibrous interface tissues, due to interface gaps and a lack of mechanical stability. It has been postulated that the differentiation of these tissues to fibrocartilage or bone is governed by mechanical stimuli. The objective of our research is to unravel these relationships to the extent that the question whether an implant will loosen can be answered from initial conditions determined by implant and interface morphology, and functional loads. In this project we studied the hypothesis that distortional strain and interstitial fluid flow are the mechanical stimuli governing tissue differentiation. For that purpose, a biomechanical regulatory model was developed and used in association with a finite element code to simulate animal experiments with implants moving in bone. The similarities between the implant incorporation process found in the experiment and its simulation with the computer model demonstrate that our hypothesis is viable from a regulatory point of view.
Similar content being viewed by others
References
S. B. GOODMAN and P. ASPENBERG, Biomaterials 13 (1992) 944.
M. HILDING, X. YUAN and L. RYD, Acta Orthop. Scand. 66 (1995) 21.
F. PAUWELS, “Biomechanics of the locomotor apparatus” (Springer-Verlag, Berlin, 1980) pp. 375–407.
N. J. GIORI, L. RYD and D. R. CARTER, J. Arthroplasty 10 (1995) 514.
D. R. CARTER, P. R. BLENMAN and G. S. BEAUPRE, J. Orthop. Res. 6 (1988) 736.
S. M. PERREN and R. A. RAHN, Canad. J. Surg. 20 (1980) 228.
H. WEINANS, R. HUISKES and H. J. GROOTENBOER, J. Biomech. 26 (1993) 1271.
K. SØBALLE, K. H. B.-RASMUSSEN, E. S. HANSEN and C. BÜNGER, J. Bone Jt. Surg. 75B (1993) 270.
P. J. PRENDERGAST and R. HUISKES, Mech. Compos. Mater. 32 (1996) 209.
P. J. PRENDERGAST, R. HUISKES and K. SØBALLE, J. Biomech. 30 (1997) 539.
A. S. JAYES and R. M. McNEIL ALEXANDER, J. Zool. Lond. 185 (1978) 298.
V. C. MOW, S. C. KUEI, W. M. LAI and C. ARMSTRONG, J. Biomech. Engng 102 (1980) 73.
J. A. OCHOA and B. M. HILLBERRY, Transact. 38th ORS 17 (1992) 162.
C. NEIDLINGER-WILKE, L. STALLA, L. CLEAS, R. A. BRAND, I. HOELLEN, S. RUBENACKER, M. ARAND and L. KINZL, J. Biomech. 28 (1995) 1411.
J. KLEIN NULEND, A. VAN DER PLAS, C. M. CEMEINS, N. E. AJUBI, J. A. FRANGOS, P. J. NIJWEIDE and E. H. BURGER, FASEB 9 (1995) 441.
R. HUISKES, H. WEINANS, H. J. GROOTENBOER, M. DALSTRA, B. FUDALA and T. J. SLOOFF, J. Biomech. 20 (1987) 1135.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
HUISKES, R., DRIEL, W.D.V., PRENDERGAST, P.J. et al. A biomechanical regulatory model for periprosthetic fibrous-tissue differentiation. Journal of Materials Science: Materials in Medicine 8, 785–788 (1997). https://doi.org/10.1023/A:1018520914512
Issue Date:
DOI: https://doi.org/10.1023/A:1018520914512