Abstract
Opioidergic mechanisms are involved in responses to nociceptive and antigenic stimuli at all levels and stages (from peripheral nociceptors to the cerebral cortex and from the precursors of immunocompetent cells to mature effector cells). In most experimental and clinical studies, opioid-mediated analgesia proved to be accompanied by immunosuppression. Opioid receptors of μ, δ, and κ types are involved in the mechanisms of combined regulation of pain and immunity, with μ and δ receptors suppressing the immune response and κ receptors enhancing it. By modifying the chemical structure of opioid ligands, it is possible to preserve the analgesic effect and avoid the development of immunosuppression. The opioidergic mechanisms are coupled with nonopioid peptidergic and nonpeptide systems of pain and immunity regulation.
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Zakharova, L.A., Vasilenko, A.M. The Opioidergic System in the Combined Regulation of Pain and Immunity. Biology Bulletin 28, 280–292 (2001). https://doi.org/10.1023/A:1016696605484
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DOI: https://doi.org/10.1023/A:1016696605484