Abstract
3-Aryl(heteryl)pyrazole-4-carbaldehydes were reduced with sodium tetrahydridoborate under mild conditions to give 3-aryl(heteryl)-4-hydroxymethylpyrazoles which were converted into the corresponding 4-chloromethyl derivatives by treatment with thionyl chloride. The subsequent reaction with triphenylphos- phine led to formation of triphenyl(4-pyrazolylmethyl)phosphonium chlorides, and Wittig reaction of the latter with aromatic or heteroaromatic aldehydes yielded 4-[2-aryl(heteryl)ethenyl]pyrazoles.
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Bratenko, M.K., Chornous, V.A. & Vovk, M.V. 4-Functionally Substituted 3-Heterylpyrazoles: VIII. 3-Aryl(heteryl)-4-hydroxyl(chloro)methylpyrazoles. Russian Journal of Organic Chemistry 38, 411–414 (2002). https://doi.org/10.1023/A:1016346528487
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DOI: https://doi.org/10.1023/A:1016346528487