REFERENCES
A.V. Shally, A. Arimura, Y. Baba, R.M.G. Nair, H. Matsuo, T.W. Redding and L. Debeljuk. Isolation and properties of the FSH and LH-releasing hormone. Biochem. Biophys. Res. Comm. 43(2): 393–399 (1971).
G. Fink, G. Gennser, P. Leidholm, J. Thorell, and J. Mulder. Comparison of plasma levels of luteinizing hormone releasing hormone in men. J. Endocrinol. 63:351–360 (1974).
J. Sandow, K. Stoeckemann, and G. Jerabek Sandow. Pharmacokinetics and endocrine effects of slow release formulations of LHRH analogues. J. Steroid Biochem. Mol. Biol. 37(6):925–931 (1990).
H. Okada, Y. Sakura, H. Kawaji, T. Yashiki, and H. Mima. Regression of rat mammary tumors by a potent luteinizing hormone-relasing hormone analogue (Leuprolide) administered vaginally. Cancer Res. 43:1869–1874 (1983).
A. Lemay, R. Maheux, N. Faure, C. Jean, and A.T.A. Fazekas. Reversible hypogonadism induced by a LHRH agonist (Buserelin) as a new therapeutic approach for endometrosis. Fertil. Steril. 41(6):863–8719 (1984).
A.R. Oyler, R.E. Naldi, J.R. Lloyd, D.A. Garden, C.J. Shaw, and M.L. Cotter. Characterization of the solution degradation products of Histrelin, a Gonadotropin Releasing Hormone (LHRH) agonist. J. Pharm. Sci. 80(3):271–275 (1991).
N. Marks, and F. Stern. Enzymatic mechanism for the inactivation of luteinizing hormone-releasing hormone (LH-RH). Biochem. Biophys. Res. Comm. 61(4):1458–1463 (1974).
A. Goren, Y. Zohar, M. Fridkin, E. Elhanati, and Y. Koch. Degradation of gonadotropin-releasing hormone in the gilthead seabream, Sparus aurata. Gen. Comp. Endocrinol. 79:291–305 (1990).
H. Ueno, and S. Matsuo. High performance liquid chromatography followed by radioimmuno assay for the determination of luteinizing hormone-releasing hormone analogue, leuprolelin, and its metabolite. J. Chromatogr. 566:57–66 (1991).
A. Lasdun, S. Reznik, C.J. Molineaux, and M. Orlowski. Inhibition of Endopeptidase 24.15 slows the in vivo degradation of luteinizing hormone releasing hormone. Am. Phamacol. Exp. Thera. 251(2):439–447 (1989).
M.M. Braford. A rapid and sensitive method for quantatition of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72:248–254 (1976).
R.L. Heinrikson, and S.C. Meredith. Amino acid analysis by reverse phase high performance liquid chromatography: Precolumn derivatization with phenylisothiocyanate. Anal. Biochem. 136:65–74 (1984).
G. Flouret, T. Majewski, D.R. Peterson, and A.J. Kenny. Effect of D-amino acid substituents on degradation of LHRH analogues by proximal tubule. Am. Physiol. E320–D326 (1987).
A. Lasdun, and M. Orlowski. Inhibition of endopeptidase 24.15 greatly increase the release to luteinizing hormone-releasing hormone. J. Pharm. Exp. Thera. 254(3):1265–1271 (1990).
T. Nakamura, T. Nagata, Y. Tanabe, N. Yanaihara, and Y. Hasegawa. Comparison of in vivo biological activities of luteinizing hormone-releasing hormone (LHRH) analogues in 60-day old cockerels. Gen. Comp. Endocrinol. 83(2):290–296 (1991).
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Han, K., Park, J.S., Chung, Y.B. et al. Identification of Enzymatic Degradation Products of Luteinizing Hormone Releasing Hormone (LHRH)/[D-Ala6] LHRH in Rabbit Mucosal Homogenates. Pharm Res 12, 1539–1544 (1995). https://doi.org/10.1023/A:1016256009141
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DOI: https://doi.org/10.1023/A:1016256009141