Abstract
Polymeric films containing salicylic acid or propranolol HC1 were prepared by casting and drying a drug-containing, aqueous colloidal polymer dispersion (Eudragit NE 30D) as an alternative to films cast from organic polymer solutions. The drug was either dissolved (salicylic acid) or dissolved/ dispersed (propranolol HC1) in the polymeric matrix. Incompatibilities (flocculation or coagulation) between salts of basic drugs and two ethylcellulose latexes were overcome by substituting the anionic surfactants with a nonionic surfactant (Pluronic P103). The drug release was studied as a function of drug loading, film thickness, amount of hydrophilic additive (hydroxypropyl methylcellulose), and storage humidity. The release of propranolol HC1 (monolithic dispersion) was a combination of diffusion through the polymer and pores or channels; the extent of each release mechanism depended on the drug loading. On DSC thermograms, melting transitions were obtained with monolithic dispersions but not with monolithic solutions. The heat of fusion was linearly correlated to the amount of drug in the films. The amount of drug remaining in the film after the dissolution study was not detectable and corresponded to the drug dissolved in the polymer. The drug release increased with increased drug loading and increased amount of hydroxypropyl methylcellulose but was independent of film thickness and relatively insensitive to different storage humidities.
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REFERENCES
R. Baker. Controlled Release of Biologically Active Agents, John Wiley & Sons, New York, 1987.
Y. Samuelov, M. Donbrow, and M. Friedman. J. Pharm. Sci. 68(3):325–329 (1979).
S. Borodkin and F. E. Tucker. J. Pharm. Sci. 63(9):1359–1364 (1974).
M. Donbrow and M. Friedman. J. Pharm. Sci. 64(1):76–80 (1975).
M. Donbrow and M. Friedman. J. Pharm. Pharmacol. 26:148–150 (1974).
I. Ghebre-Sellassie, R. H. Gordon, R. U. Nesbitt, and M. B. Fawzi. Int. J. Pharm. 37:211–218 (1987).
F. W. Goodhart, M. R. Harris, K. S. Murthy, and R. U. Nesbitt. Pharm. Tech. 4:64–71 (1984).
G. S. Banker and G. E. Peck. Pharm. Tech. 4:55–61 (1981).
S. Büyükyaylaci, Y. M. Joshi, G. E. Peck, and G. S. Banker. In J. M. Anderson and S. W. Kim (eds.), Recent Advances in Drug Delivery Systems, Plenum Press, New York, 1984, pp. 291–307.
R. Gurny, N. A. Peppas, D. D. Harrington, and G. S. Banker. Drug Dev. Indust. Pharm. 7(1):1–25 (1981).
Y. Kawashima, H. Takeuchi, T. Handa, W. J. Thiele, D. P. Deen, and J. W. McGinity. In J. W. McGinity (ed.), Aqueous Polymeric Coatings for Pharmaceutical Applications, Marcel Dekker, New York, 1989, pp. 363–397.
K. O. R. Lehmann. In J. W. McGinity (ed.), Aqueous Polymeric Coatings for Pharmaceutical Applications, Marcel Dekker, New York, 1989, pp. 153–245.
H. Nyqvist. Int. J. Pharm. Tech. Prod. Mfr. 4(2):47–48 (1983).
C. R. Steuernagel. In J. W. McGinity (ed.), Aqueous Polymeric Coatings for Pharmaceutical Applications, Marcel Dekker, New York, 1989, pp. 1–61.
H. Kast. Makromol. Chem. Suppl. 10/11:447–461 (1985).
J. W. Vanderhoff. J. Polymer Sci. Symp. No. 41:155–174 (1973).
D. P. Sheetz. J. Appl. Polymer Sci. 9:3759–3773 (1965).
J. Lampert. Colloid Polymer Sci. 258:960–967 (1980).
H. Goodman and G. S. Banker. J. Pharm. Sci. 59(8):1131–1137).
R. Baker. Controlled Release of Biologically Active Agents, John Wiley & Sons, New York, 1987, pp. 39–83.
F. Theeuwes, A. Hussain, and T. Higuchi. J. Pharm. Sci. 63(3):427–429 (1974).
A. M. Mehta and D. M. Jones. Pharm. Technol. 6:52–60 (1985).
T. Higuchi. J. Pharm. Sci. 52(12):1145–1149 (1963).
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Bodmeier, R., Paeratakul, O. Evaluation of Drug-Containing Polymer Films Prepared from Aqueous Latexes. Pharm Res 6, 725–730 (1989). https://doi.org/10.1023/A:1015950825398
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DOI: https://doi.org/10.1023/A:1015950825398