Abstract
The effect of physical aging on the dissolution and mechanical properties of hydroxypropyl methyl-cellulose phthalate (HPMCP) was investigated. Dissolution rate measurements were performed on films which, initially above the glass transition temperature, T g, were quenched to a sub-T g storage temperature, aged at that temperature for a period of time and then quenched again to 25°C. Within the time scale of observation, reductions in the dissolution rate to a limiting value were observed. HPMCP was also found to age in the same storage temperature range as determined by a creep compliance technique. These mechanical results indicate a change in glass structure and show that a limiting density was approached. Parallel changes were observed in the dissolution rate studies suggest that dissolution rate is governed in part by glass density. Therefore, mechanical changes of glassy films can yield pharmaceutically relevant information about the extent of physical aging and serve as an indicator of the effect of aging on dissolution rate.
Similar content being viewed by others
REFERENCES
J. Spitael and R. Kinget. Pharm. Ind. 39:502–505 (1977).
E. Shek. Pharm. Ind. 40:981–982 (1978).
S. S. Ozturk, B. O. Palsson, B. Donohoe, and J. B. Dressman. Pharm. Res. 5:550–565 (1988).
R. S. Harland, A. Gazzaniga, M. E. Sangalli, P. Colombo, and N. A. Peppas. Pharm. Res. 5:488–494 (1988).
P. I. Lee and N. A. Peppas. J. Contr. Rel. 6:207–215 (1987).
G. P. Johari. In K. L. Ngai and G. Wright (eds.), Relaxations in Complex Systems, Government Printing Press, Washington, DC, 1985, pp. 17–41.
S. B. Elliot. The Physics of Amorphous Materials, Longman, New York, 1983.
M. R. Tant and G. L. Wilkes. Poly. Eng. Sci. 21:874–895 (1981).
L. C. E. Struik. The Physical Aging Behavior of Amorphous Materials, Elsevier, New York, 1978, pp. 19–27.
C. R. Foltz and P. V. McKinney. J. Appl. Poly. Sci. 13:2235–2245 (1969).
I. M. Hodge and A. R. Berens. Macromolecules 15:762–770 (1982).
R. W. Rendell, T. K. Lee, and K. L. Ngai. Poly. Eng. Sci. 24:1104–1110 (1984).
L. C. E. Struik. In W. Brostow and R. D. Corneliussen (eds.), Failure of Plastics, Macmillan, New York, 1986, pp. 209–258.
K. H. Illers. Makromol. Chem. 127:1–33 (1969).
A. H. Chan. Ph.D. dissertation, University of Texas, Austin, 1978.
E. S. W. Kong. Adv. Poly. Sci. 80:125–171 (1986).
J. H. Kou. Ph.D. dissertation, University of Michigan, Ann Arbor, 1988, p. 22.
G. Levita and L. C. E. Struik. Polymer 24:1071–1074 (1983).
A. F. Yee. Poly. Eng. Sci. 17:213 (1977).
L. C. E. Struik. Polymer 21:962 (1980).
D. J. Plazek, K. L. Ngai, and R. W. Rendell. Poly. Eng. Sci. 24:1111–1116 (1984).
C. K. Chai and N. G. McCrum. Polymer 21:706 (1980).
K. L. Ngai. In T. V. Ramakrishnan (ed.), Non-Debye Relaxations in Condensed Matter, World Scientific Press, Singapore, 1985, p. 58.
A. K. Rajagopal, S. Teitler, and K. L. Ngai. J. Phys. C Solid. State. Phys. 17:6611–6622 (1984).
V. Levich. Physicochemical Hydrodynamics, Prentice Hall, Englewood Cliffs, NJ, 1962.
J. P. Delporte. Pharm. Ind. 41:984–990 (1979).
J. G. Wagner, G. W. Ryan, E. Kubiak, and S. Long. J. Am. Pharm. Assoc. (Sci. Ed.) 49:133–139 (1960).
F. Brochard and P. G. Degennes. Physiochem. Hydrodynam. 4:313–324 (1983).
R. W. Rendell, K. L. Ngai, and A. F. Yee. Mat. Res. Soc. Symp. Proc. 79:311–324 (1987).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Sinko, C.M., Yee, A.F. & Amidon, G.L. The Effect of Physical Aging on the Dissolution Rate of Anionic Polyelectrolytes. Pharm Res 7, 648–653 (1990). https://doi.org/10.1023/A:1015882631082
Issue Date:
DOI: https://doi.org/10.1023/A:1015882631082