Skip to main content
SpringerLink
Log in

Structure and Functions of Classical Cadherins

  • Published:
Biochemistry (Moscow) Aims and scope Submit manuscript

Abstract

Cadherins are a family of membrane receptors that mediate calcium-dependent homophilic cell–cell adhesion. Cadherins play a key role in the regulation of organ and tissue development during embryogenesis. In adult organisms, these proteins are responsible for formation of stable cell–cell junctions and maintenance of normal tissue structure. Disruption in expression or function of cadherins may cause uncontrolled cell migration and proliferation during tumor development. This review focuses on the structure and physiological functions of classical cadherins.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

REFERENCES

  1. Grunwald, G. B. (1993) Curr. Opin. Cell Biol., 5, 797–805.

    Google Scholar 

  2. Burridge, K., Fath, K., Kelly, T., Nuckolls, G., and Tutner, C. (1988) Annu. Rev. Cell Biol., 4, 487–525.

    Google Scholar 

  3. Garrode, D. R. (1993) Curr. Opin. Cell Biol., 5, 30–40.

    Google Scholar 

  4. Gumbiner, B. M. (1996) Cell, 84, 345–357.

    Google Scholar 

  5. Burridge, K., and Chrzanovska-Wodnichka, M. (1996) Annu. Rev. Cell Dev. Biol., 12, 463–519.

    Google Scholar 

  6. Geiger, B., and Ayalon, O. (1992) Ann. Rev. Cell Biol., 8, 307–332.

    Google Scholar 

  7. Yap, A. S., Brieher, W. M., and Gumbiner, B. M. (1997) Ann. Rev. Cell Dev. Biol., 13, 119–46.

    Google Scholar 

  8. Vleminckx, K., and Kemler, R. (1999) BioEssays, 21, 211–220.

    Google Scholar 

  9. Angst, B. D., Marcozzi, C., and Magee, A. I. (2001) J. Cell Sci., 114, 629–641.

    Google Scholar 

  10. Takeichi, M. (1995) Curr. Opin. Cell Biol., 7, 619–627.

    Google Scholar 

  11. Ozawa, T., Ringwald, M., and Kemler, R. (1990) Proc. Natl. Acad. Sci. USA, 87, 4246–4250.

    Google Scholar 

  12. Rimm, D. L., Koslov, E. R., Kebriaei, P., Cianci, C. D., and Morrow, J. S. (1995) Proc. Natl. Acad. Sci. USA, 92, 8813–8817.

    Google Scholar 

  13. Nagafuchi, A., and Takeichi, M. (1988) EMBO J., 7, 3679–3684.

    Google Scholar 

  14. Brieher, W. M., Yap, A. S., and Gumbiner, B. M. (1996) J. Cell Biol., 135, 487–496.

    Google Scholar 

  15. Nose, A., Nagafuchi, A., and Takeichi, M. (1988) Cell, 54, 993–1001.

    Google Scholar 

  16. Takeichi, M. (1991) Science, 251, 1451–1455.

    Google Scholar 

  17. Nose, A., Tsui, K., and Takeichi, M. (1990) Cell, 61, 147–155.

    Google Scholar 

  18. Blaschuk, O. W., Sullivan, R., David, S., and Pouliot, Y. (1990) Dev. Biol., 139, 227–229.

    Google Scholar 

  19. Cepek, K. L., Shaw, S. K., Parker, C. M., Russell, G. J., Morrow, J. S., Rimm, D. L., and Brenner, M. B. (1994) Nature, 372, 190–193.

    Google Scholar 

  20. Williams, E. J., Furness, J., Walsh, F. S., and Doherty, P. (1994) Neuron, 13, 583–594.

    Google Scholar 

  21. Doherty, P., Williams, G., and Williams, E. J. (2000) Mol. Cell. Neurosci., 16, 283–95.

    Google Scholar 

  22. Shapiro, L., Fannon, A. M., and Kwong, P. D. (1995) Nature, 374, 327–337.

    Google Scholar 

  23. Nagar, B., Overduin, M., Ikura, M., and Rini, J. M. (1996) Nature, 380, 360–364.

    Google Scholar 

  24. Hirokawa, N., and Heuser, J. E. (1981) J. Cell Biol., 91, 399–409.

    Google Scholar 

  25. Ozawa, M., Baribault, H., and Kemler, R. (1989) EMBO J., 8, 1711–1717.

    Google Scholar 

  26. McCrea, P., and Gumbiner, B. (1991) J. Biol. Chem., 266, 4514–4520.

    Google Scholar 

  27. Hirano, S., Kimoto, N., Shimoyama, Y., Hirohashi, S., and Takeichi, M. (1992) Cell, 70, 293–301.

    Google Scholar 

  28. Kintner, C. (1992) Cell, 69, 225–236.

    Google Scholar 

  29. Watabe, M., Nagafuchi, A., Tsukita, S., and Takeichi, M. (1994) J. Cell Biol., 127, 247–256.

    Google Scholar 

  30. Cox, R. T., Kirkpatrick, C., and Peifer, M. (1996) J. Cell Biol., 134, 133–148.

    Google Scholar 

  31. Stappert, J., and Kemler, R. (1994) Cell Adhes. Commun., 130, 369–381.

    Google Scholar 

  32. Aberle, H., Butz, S., Stappert, J., Weissig, H., Kemler, R., and Hoschuetzky, H. (1994) J. Cell Sci., 107, 3655–3663.

    Google Scholar 

  33. Jou, T-S., Stewart, D. B., Stappert, J., Nelson, W. J., and Marrs, J. A. (1995) Proc. Natl. Acad. Sci. USA, 92, 5067–5071.

    Google Scholar 

  34. Hulsken, J., Birchmeier, W., and Behrens, J. (1994) J. Cell Biol., 127, 2061–2069.

    Google Scholar 

  35. Oyama, T., Kanai, Y., Ochiai, A., Akimoto, S., and Oda, T. (1994) Cancer Res., 54, 6282–6287.

    Google Scholar 

  36. Funayama, N., Fagotto, F., McCrea, P., and Gumbiner, B. M. (1995) J. Cell Biol., 128, 959–968.

    Google Scholar 

  37. Fujimori, T., and Takeichi, M. (1993) Mol. Biol. Cell, 4, 37–47.

    Google Scholar 

  38. Hermiston, M. L., and Gordon, J. L. (1995) J. Cell Biol., 129, 489–506.

    Google Scholar 

  39. Knudsen, K. A., Soler, A. P., Johnson, K. R., and Wheelok, M. J. (1995) J. Cell Biol., 130, 67–77.

    Google Scholar 

  40. Peifer, M., and Wieschaus, E. (1990) Cell, 63, 1167–1178.

    Google Scholar 

  41. Peifer, M., Berg, S., and Reynolds, A. B. (1994) Cell, 76, 789–791.

    Google Scholar 

  42. Nagafuchi, A., Ishihara, S., and Tsukita, S. (1994) J. Cell Biol., 127, 235–245.

    Google Scholar 

  43. Cowin, P., Kapprell, H.-P., Franke, W. W., Tamkun, J., and Hynes, R. O. (1986) Cell, 46, 1063–1073.

    Google Scholar 

  44. Korman, N. J., Eyre, R. W., Klaus-Kowtun, V., and Stanley, J. R. (1989) N. Engl. J. Med., 321, 631–635.

    Google Scholar 

  45. Witcher, L. L., Collins, R., Puttagunta, S., Mechanic, S. E., Munson, M., Gumbiner, B., and Cowin, P. (1996) J. Biol. Chem., 271, 10904–10909.

    Google Scholar 

  46. Franke, W. W., Goldschmidt, M. A., Zimbelmann, R., Mueller, H. M., Schiller, D. L., and Cowin, P. (1989) Proc. Natl. Acad. Sci. USA, 86, 4027–4031.

    Google Scholar 

  47. Haegel, H., Larue, L., Ohsugi, M., Fedorov, L., Herrenknecht, K., and Kemler, R. (1995) Development, 121, 3529–3537.

    Google Scholar 

  48. Bierkamp, C., Mclaughlin, K. J., Schwarz, H., Huber, O., and Kemler, R. (1996) Dev. Biol., 180, 780–785.

    Google Scholar 

  49. Brady-Kalnay, S. M., Rimm, D. L., and Tonks, N. K. (1995) J. Cell Biol., 130, 977–986.

    Google Scholar 

  50. Kypta, R. M., Su, H., and Reichardt, L. F. (1996) J. Cell Biol., 134, 1519–1529.

    Google Scholar 

  51. Reynolds, A. B., Daniel, J., McCrea, P., Wheelock, M. J., Wu, J., and Zhang, Z. (1994) Mol. Cell. Biol., 14, 8333–8342.

    Google Scholar 

  52. Shibamoto, S., Hayakawa, M., Takeuchi, K., Hori, T., and Miyazawa, K. (1995) J. Cell Biol., 128, 949–957.

    Google Scholar 

  53. Staddon, J. M., Smales, C., Schulze, C., Esch, F. S., and Rubin, L. L. (1995) J. Cell Biol., 130, 369–381.

    Google Scholar 

  54. Nagafuchi, A., Takeichi, M., and Tsukita, S. (1991) Cell, 65, 849–857.

    Google Scholar 

  55. Roh, J.-Y., and Stanley, J. R. (1995) J. Cell Biol., 128, 939–947.

    Google Scholar 

  56. Fannon, A. M., Sherman, D. L., Ilyina-Gragerova, G., Brophy, P. J., Friedrich, V. L. J., and Colman, D. R. (1995) J. Cell Biol., 129, 189–202.

    Google Scholar 

  57. Fannon, A. M., and Colman, D. R. (1996) Neuron, 17, 423–434.

    Google Scholar 

  58. Uchida, N., Honjo, Y., Johnson, K. R., Wheelock, M. J., and Takeichi, M. (1996) J. Cell Biol., 135, 767–797.

    Google Scholar 

  59. Volk, T., and Geiger, B. (1986) J. Cell Biol., 103, 1441–1450.

    Google Scholar 

  60. Mooseker, M. S., Bonder, E. M., Conzelman, K. A., Fishkind, D. J., Howe, C. L., and Keller, T. C. S. I. (1984) J. Cell Biol., 99, 104–112s.

    Google Scholar 

  61. Madara, J. L. (1987) Am. J. Physiol., 253, C171–175.

    Google Scholar 

  62. Madara, J. L., Moore, R., and Carlson, S. (1987) Am. J. Physiol., 253, 854–861.

    Google Scholar 

  63. Madara, J. L., Stafford, J., Barenberg, D., and Carlson, S. (1988) Am. J. Physiol., 254, G416–423.

    Google Scholar 

  64. Duband, J.-L., Dufour, S., Hatta, K., Takeichi, M., and Edelman, G. M. (1987) J. Cell Biol., 104, 1361–1374.

    Google Scholar 

  65. Duband, J.-L., Volberg, T., Sabanay, I., Thiery, J.-P., and Geiger, B. (1988) Development, 103, 325–344.

    Google Scholar 

  66. Tsukita, S., Tsukita, S., Nagafuchi, A., and Yonemura, S. (1992) Curr. Opin. Cell Biol., 4, 834–839.

    Google Scholar 

  67. Muller, J.-A. J., and Wieschaus, E. (1996) J. Cell Biol., 134, 149–163.

    Google Scholar 

  68. Grawe, F., Wodarz, A., Lee, B., Knust, E., and Skaer, H. (1996) Development, 122, 951–959.

    Google Scholar 

  69. Tepass, U. (1996) Dev. Biol., 177, 217–225.

    Google Scholar 

  70. Wodarz, A., Hinz, U., Engelbert, N., and Knust, E. (1995) Cell, 82, 67–76.

    Google Scholar 

  71. Nakagawa, S., and Takeichi, M. (1995) Development, 121, 1321–1332.

    Google Scholar 

  72. Bradley, R. S., Cowin, P., and Brown, A. M. C. (1993) J. Cell Biol., 123, 1857–1865.

    Google Scholar 

  73. Hinck, L., Nelson, W. J., and Papkoff, J. (1994) J. Cell Biol., 124, 729–741.

    Google Scholar 

  74. Shibamoto, S., Hayakawa, M., Takeuchi, K., Hori, T., and Oku, N. (1994) Cell Adhes. Commun., 1, 295–305.

    Google Scholar 

  75. Brabant, G., Hoang-Vu, C., Behrends, J., Cetin, Y., and Potter, E. (1995) Endocrinology, 136, 3113–3119.

    Google Scholar 

  76. Bracke, M. E., Vyncke, B. M., Bruyneel, E. A., Vermeulen, S. J., and De Bruyne, G. K. (1995) Br. J. Cancer, 68, 282–289.

    Google Scholar 

  77. Paul, D. L., Yu, K., Bruzzone, R., Gimlich, R. L., and Goodenough, D. A. (1995) Development, 121, 371–381.

    Google Scholar 

  78. Williams, S. L., Hayes, V. Y., Hummel, A. M., Tarara, J. E., and Healsey, T. J. (1993) J. Cell Biol., 121, 643–654.

    Google Scholar 

  79. Winkel, G. K., Ferguson, J. E., Takeichi, M., and Nuccitelli, R. (1990) Dev. Biol., 138, 1–15.

    Google Scholar 

  80. Matsuyoshi, N., Hamaguchi, M., Taniguchi, S., Nagafuchi, A., Tsukita, S., and Takeichi, M. (1992) J. Cell Biol., 118, 703–714.

    Google Scholar 

  81. Hamaguchi, M., Matsuyoshi, N., Ohnishi, Y., Gotoh, B., Takeichi, M., and Nagai, Y. (1993) Dev. Suppl., 41–46.

  82. Behrens, J., Vakaet, L., Friis, R., Winterhager, E., and Roy, F. V. (1993) J. Cell Biol., 120, 757–766.

    Google Scholar 

  83. Takeda, H., Nagafuchi, A., Yonemura, S., Tsukita, S., and Behrens, J. (1995) J. Cell Biol., 131, 1839–1847.

    Google Scholar 

  84. Reynolds, A. B., Herbert, L., Cleveland, J. L., Berg, S. T., and Gaut, J. R. (1992) Oncogene, 7, 2439–2445.

    Google Scholar 

  85. Daniel, J. M., and Reynolds, A. B. (1995) Mol. Cell. Biol., 15, 4819–4824.

    Google Scholar 

  86. Khoury, H., Dankort, D. L., Sadekova, S., Naujokas, M. A., Muller, W. S., and Park, M. (2001) Oncogene, 20, 788–799.

    Google Scholar 

  87. Hoschuetzky, H., Aberle, H., and Kemler, R. (1994) J. Cell Biol., 127, 1375–1380.

    Google Scholar 

  88. Zondag, G. C., Moolenaar, W. H., and Gebbink, M. F. (1996) J. Cell Biol., 134, 1513–1517.

    Google Scholar 

  89. Meyer, R. A., Laird, D. W., Revel, J.-P., and Johnson, R. G. (1992) J. Cell Biol., 119, 179–189.

    Google Scholar 

  90. Steinberg, M. S., and Takeichi, M. (1994) Proc. Natl. Acad. Sci. USA, 91, 206–209.

    Google Scholar 

  91. Angres, B., Barth, A., and Nelson, W. J. (1996) J. Cell Biol., 134, 549–557.

    Google Scholar 

  92. Vestweber, D., Gossler, A., Boller, K., and Kemler, R. (1987) Dev. Biol., 124, 451–456.

    Google Scholar 

  93. Rosales, C., O.Brien, V., Kornberg, L., and Juliano, R. (1995) Biochim. Biophys. Acta, 1242, 77–98.

    Google Scholar 

  94. Gumbiner, B. (1990) Curr. Opin. Cell Biol., 2, 881–887.

    Google Scholar 

  95. Doherty, P., Ashton, S. V., Moore, S. E., and Walsh, F. S. (1991) Cell, 67, 21–33.

    Google Scholar 

  96. Bixby, J. L., Grunwald, G. B., and Bookman, R. J. (1994) J. Cell Biol., 127, 1461–1475.

    Google Scholar 

  97. Tsukita, S., Oishi, K., Akiyama, T., Yamanashi, Y., Tamamoto, T., and Tsukita, S. (1991) J. Cell Biol., 113, 867–879.

    Google Scholar 

  98. Woods, D. F., and Bryant, L. (1993) J. Cell Sci. Suppl., 17, 171–181.

    Google Scholar 

  99. Ko, K. S., Arora, P. D., Bhide, V. V., Chen, A., and McCulloch, C. A. (2001) J. Cell Sci., 114(Pt. 6), 1155–1167.

    Google Scholar 

  100. Pece, S., and Gutkind, J. S. (2000) J. Biol. Chem., 275, 41227–41233.

    Google Scholar 

  101. Kim, S. H., Li, Z., and Sacks, D. B. (2000) J. Biol. Chem., 275, 36999–37005.

    Google Scholar 

  102. Gumbiner, B. (1995) Curr. Opin. Cell Biol., 7, 634–640.

    Google Scholar 

  103. Peifer, M. (1995) Trends Cell Biol., 5, 224–229.

    Google Scholar 

  104. Miller, J. R., and Moon, R. T. (1996) Genes Dev., 10, 2527–2539.

    Google Scholar 

  105. Resnik, E. (1997) Nat. Genet., 16, 9–11.

    Google Scholar 

  106. Fagotto, F., and Gumbiner, B. M. (1996) Dev. Biol., 180, 445–454.

    Google Scholar 

  107. Orsulic, S., and Peifer, M. (1996) J. Cell Biol., 134, 1283–1300.

    Google Scholar 

  108. Behrens, J., von Kries, J. P., Kuhl, M., Bruhn, L., and Wedlich, D. (1996) Nature, 382, 638–642.

    Google Scholar 

  109. Molenaar, M., van de Wetering, M., Oosterwegel, M., Peterson-Maduro, J., and Godsave, S. (1996) Cell, 86, 391–399.

    Google Scholar 

  110. Novak, A., and Dedhar, S. (1999) Cell. Mol. Life Sci., 56, 523–537.

    Google Scholar 

  111. Ling, Y., Zhong, Y., and Perez-Soler, R. (2001) Mol. Pharmacol., 59, 593–603.

    Google Scholar 

  112. Sanson, B., White, P., and Vincent, J.-P. (1996) Nature, 383, 627–630.

    Google Scholar 

  113. Hafen, E., Dickson, B., Raabe, T., Brunner, D., Oellers, N., and van der Straten, A. (1993) Dev. Suppl., 41–46.

  114. Artavanis-Tsakonas, S., Matsuno, K., and Fortini, M. E. (1995) Science, 268, 225–232.

    Google Scholar 

  115. Bosenberg, M. W., and Massague, J. (1993) Curr. Opin. Cell Biol., 5, 832–838.

    Google Scholar 

  116. Musil, L. S., Cunningham, B. A., Edelman, G. M., and Goodenough, D. A. (1990) J. Cell Biol., 111, 2077–2088.

    Google Scholar 

  117. Townes, P., and Holtfretter, J. (1955) J. Exp. Zool., 128, 53–120.

    Google Scholar 

  118. Hyafil, F., Morello, D., Babinet, C., and Jacob, F. (1980) Cell, 21, 927–934.

    Google Scholar 

  119. Hyafil, F., Babinet, C., and Jacob, F. (1981) Cell, 26, 447–454.

    Google Scholar 

  120. Reima, I. (1990) Cell Differ. Dev., 29, 143–153.

    Google Scholar 

  121. Ao, A., and Erickson, R. P. (1992) Antisense Res. Dev., 2, 153–163.

    Google Scholar 

  122. Larue, L., Ohsugi, M., Hirchenhain, J., and Kemler, R. (1994) Proc. Natl. Acad. Sci. USA, 91, 8263–8267.

    Google Scholar 

  123. Riethmacher, D., Brinkmann, V., and Birchmeier, C. (1995) Proc. Natl. Acad. Sci. USA, 92, 855–859.

    Google Scholar 

  124. Heasman, J., Ginsberg, D., Geiger, B., Goldstone, K., Pratt, T., Yoshida-Noro, C., and Wylie, C. (1994) Development, 120, 49–57.

    Google Scholar 

  125. Hatta, K., Takagi, S., Fujisawa, H., and Takeichi, M. (1987) Dev. Biol., 120, 215–227.

    Google Scholar 

  126. Hatta, K., Nose, A., Nagafuchi, A., and Takeichi, M. (1988) J. Cell Biol., 106, 873–881.

    Google Scholar 

  127. Mege, R. M., Matsuzaki, F., Gallin, W. J., Goldberg, J. I., and Cunningham, B. A. (1988) Proc. Natl. Acad. Sci. USA, 85, 7274–7278.

    Google Scholar 

  128. McNeili, H., Ozawa, M., Kemler, R., and Nelson, W. J. (1990) Cell, 62, 309–316.

    Google Scholar 

  129. Behrens, J., Mareel, M. M., Van Roy, F. M., and Birchmeier, W. (1989) J. Cell Biol., 108, 2435–2447.

    Google Scholar 

  130. Frixen, U. H., Behrens, J., and Sachs, M. (1991) J. Cell Biol., 113, 173–185.

    Google Scholar 

  131. Thiery, J. P., Boyer, B., Tucker, G., Gavrilovic, J., and Valles, A. M. (1988) Ciba Found. Symp., 141, 48–74.

    Google Scholar 

  132. Redies, C., Engelhart, K., and Takeichi, M. (1993) J. Comp. Neurosci., 333, 398–416.

    Google Scholar 

  133. Redies, C., and Muller, H.-A. (1994) Cell Adhes. Commun., 2, 511–520.

    Google Scholar 

  134. Murphy-Erdoch, C., Napolitano, E. W., and Reichardt, L. F. (1994) Dev. Biol., 161, 107–125.

    Google Scholar 

  135. Shimamura, K., and Takeichi, M. (1992) Development, 116, 1011–1019.

    Google Scholar 

  136. Ganzler, S., and Redies, C. (1995) J. Neurosci., 15, 4157–4172.

    Google Scholar 

  137. Fredette, B. J., and Ranscht, B. (1994) J. Neurosci., 14, 7331–7346.

    Google Scholar 

  138. Friedlander, D. R., Mege, R. M., Cunningham, B. A., and Edelman, G. M. (1989) Proc. Natl. Acad. Sci. USA, 86, 7043–7047.

    Google Scholar 

  139. Radice, J. L., Rayburn, H., Matsunami, H., Knudsen, K. A., Takeichi, M., and Hynes, R. O. (1997) Dev. Biol., 181, 64–78.

    Google Scholar 

  140. Redies, C., and Takeichi, M. (1996) Dev. Biol., 180, 413–423.

    Google Scholar 

  141. Redies, C. (1997) Cell Tissue Res., 290, 405–413.

    Google Scholar 

  142. Riehl, R., Johnson, K., Bradley, R., Grunwald, G. B., Cornel, E., Lilienbaum, A., and Holt, C. E. (1996) Neuron, 17, 837–848.

    Google Scholar 

  143. Matsunaga, M., Hatta, K., Nagafuchi, A., and Takeichi, M. (1988) Nature, 334, 62–64.

    Google Scholar 

  144. Doherty, P., Cohen, J., and Walsh, F. S. (1990) Neuron, 5, 209–219.

    Google Scholar 

  145. Doherty, P., Fruns, M., Seaton, P., Dickson, G., Barton, C. H., Seras, T. A., and Walsh, F. S. (1990) Nature, 343, 464–466.

    Google Scholar 

  146. Doherty, P., Rowett, L. H., Moore, S. E., Mann, D. A., and Walsh, F. S. (1991) Neuron, 6, 247–258.

    Google Scholar 

  147. Fredette, B. J., Miller, J., and Ranscht, B. (1996) Development, 122, 3163–3171.

    Google Scholar 

  148. Cifuentes-Diaz, C., Nicolet, M., Goudou, D., Rieger, F., and Mege, R. M. (1994) Development, 120, 1–11.

    Google Scholar 

  149. Chifuentes-Diaz, C., Goudou, D., Padilla, F., Facchinetti, P., Nicolet, M., Mege, P. M., and Rieger, F. (1996) Eur. J. Neurosci., 8, 1666–1676.

    Google Scholar 

  150. Tanaka, H., Shan, W., Phillips, G. R., Arndt, K., Bozdagi, O., Shapiro, L., Huntley, G. W., Benson, D. L., and Colman, D. R. (2000) Neuron, 25, 93–107.

    Google Scholar 

  151. Uemura, T. (1998) Cell, 93, 1095–1098.

    Google Scholar 

  152. Ranscht, B. (2000) Int. J. Dev. Neurosci., 18, 643–651.

    Google Scholar 

  153. Bruses, J. L. (2000) Curr. Opin. Cell Biol., 12, 593–597.

    Google Scholar 

  154. Suzuki, S. C., Inoue, T., Kimura, Y., Tanaka, T., and Takeichi, M. (1997) Mol. Cell. Neurosci., 9, 433–447.

    Google Scholar 

  155. Inoue, A., and Sanes, J. R. (1997) Science, 276, 1428–1431.

    Google Scholar 

  156. Albeda, S. M. (1993) Lab. Invest., 68, 4–17.

    Google Scholar 

  157. Vasiliev, J. M., and Gelfand, I. M. (1981) Neoplastic and Normal Cells in Culture, Cambridge University Press, London.

    Google Scholar 

  158. Takeichi, M. (1993) Curr. Opin. Cell Biol., 5, 806–811.

    Google Scholar 

  159. Shiozaki, H., Tahara, H., and Oka, H. (1991) Am. J. Pathol., 139, 17–23.

    Google Scholar 

  160. Schipper, J. H., Frixen, U. H., Behrens, J., Unger, A., Jahnke, K., and Birchmeier, W. (1991) Cancer Res., 51, 6328–6337.

    Google Scholar 

  161. Perl, A. K., Wilgenbus, P., Dahl, U., Semb, H., and Christofori, G. (1998) Nature, 392, 190–193.

    Google Scholar 

  162. Christofori, G., and Semb, H. (1999) Trends Biochem. Sci., 24, 73–76.

    Google Scholar 

  163. Navarro, P., Gomez, M., Pizarro, A., Gamallo, C., Quintanilla, M., and Cano, A. (1991) J. Cell Biol., 115, 517–533.

    Google Scholar 

  164. Vleminckx, K., Vakaet, L., Mareel, M., Fiers, W., and Van Roy, F. (1991) Cell, 66, 107–119.

    Google Scholar 

  165. Chen, W., and Obrink, B. (1991) J. Cell Biol., 114, 319–327.

    Google Scholar 

  166. Smythe, W. R., Williams, J. P., Wheelock, M. J., Johnson, K. R., Kaiser, L. R., and Albelda, S. M. (1999) Lung Cancer, 24, 157–168.

    Google Scholar 

  167. Seline, P. C., Norris, D. A., Horikawa, T., Fujita, M., and Middleton, M. H. (1996) J. Invest. Dermatol., 106, 1320–1324.

    Google Scholar 

  168. Hazan, R. B., Kang, L., Whooley, B. P., and Borgen, P. I. (1997) Cell Adhes. Commun., 4, 399–411.

    Google Scholar 

  169. Islam, S., Carey, G. T., Wolf, M. G., Wheelock, M. J., and Johnson, K. R. (1996) J. Cell Biol., 135, 1643–1654.

    Google Scholar 

  170. Hazan, R. B., Phillips, G. R., Qiao, R. F., Norton, L., and Aaronson, S. A. (2000) J. Cell Biol., 148, 779–790.

    Google Scholar 

  171. Bodmer, W. (1999) Cytogenet. Cell Genet., 86, 99–104.

    Google Scholar 

  172. Morin, P. J., Sparks, A. B., Korinek, V., Barker, N., Clevers, H., Vogelstein, B., and Kinzler, K. W. (1997) Science, 275, 1787–1790.

    Google Scholar 

  173. Ranscht, B., and Dours-Zimmermann, M. T. (1991) Neuron, 7, 391–402.

    Google Scholar 

  174. Vestal, D. J., and Ranscht, B. (1992) J. Cell Biol., 119, 451–461.

    Google Scholar 

  175. Ranscht, B., and Bronner-Fraser, M. (1991) Development, 111, 15–22.

    Google Scholar 

  176. Tanihara, H., Sano, K., Heimark, R. L., St. John, T., and Suzuki, S. (1994) Cell Adhes. Commun., 2, 15–26.

    Google Scholar 

  177. Takeuchi, T., Misaki, A., Chen, B. K., and Ohtsuki, Y. (1999) Histopathology, 35, 87–8.

    Google Scholar 

  178. Kawakami, M., Staub, J., Cliby, W., Hartmann, L., Smith, D. I., and Shridar, V. (1999) Int. J. Oncol., 15, 715–720.

    Google Scholar 

  179. Sato, M., Mori, Y., Sakurada, A., Fujimura, S., and Horii, A. (1998) J. Hum. Genet., 43, 285–286.

    Google Scholar 

  180. Sato, M., Mori, Y., Sakurada, A., Fujimura, S., and Horii, A. (1998) Hum. Genet., 103, 96–101.

    Google Scholar 

  181. Mori, Y., Matsunaga, M., Abe, T., Fukushige, S., Miura, K., Sunamura, M., Shiiba, K., Sato, M., Nukiwa, T., and Horii, A. (1999) Br. J. Cancer, 80, 556–562.

    Google Scholar 

  182. Lee, S. W. (1996) Nat. Med., 2, 776–782.

    Google Scholar 

  183. Lee, S. W. (1998) Carcinogenesis, 19, 1157–1159.

    Google Scholar 

  184. Takeuchi, T., Misaki, A., Liang, S. B., Tachibana, A., Hayashi, N., Sonobe, H., and Ohtsuki, Y. (2000) J. Neurochem., 74, 1489–1497.

    Google Scholar 

  185. Koller, E., and Ranscht, B. (1996) J. Biol. Chem., 22, 30061–30067.

    Google Scholar 

  186. Stefanova, I., Horeishi, V., Ansotegui, I. J., Knapp, W., and Stockinger, H. (1991) Science, 254, 1016–1019.

    Google Scholar 

  187. Shenoy-Scaria, A. M., Kwong, J., Fujita, T., Olszowy, M. W., Shaw, A. S., and Lublin, D. M. (1992) J. Immunol., 149, 3535–3541.

    Google Scholar 

  188. Solomon, K. R., Rudd, C. E., and Finberg, R. W. (1996) Proc. Natl. Acad. Sci. USA, 93, 6053–6058.

    Google Scholar 

  189. Philippova, M. P., Bochkov, V. N., Stambolsky, D. V., Tkachuk, V. A., and Resink, T. J. (1998) FEBS Lett., 429, 207–210.

    Google Scholar 

  190. Anderson, R. G. W. (1998) Annu. Rev. Biochem., 67, 199–225.

    Google Scholar 

  191. Jang, Y., Lincoff, A. M., Plow, E. F., and Topol, E. J. (1994) J. Am. Coll. Cardiol., 24, 1591–1601.

    Google Scholar 

  192. Hamon, M., Bauters, C., McFadden, E. P., Wernert, N., Lablanche, J. M., Dupuis, B., and Bertand, M. E. (1995) Eur. Heart J., 16(Suppl. 1), 33–48.

    Google Scholar 

  193. Ivanov, D., Philippova, M., Antropova, J., Gubaeva, F., Iljinskaya, O., Tararak, E., Bochkov, V., Erne, P., Resink, T., and Tkachuk, V. (2001) Histochem. Cell Biol., 115, 231–242.

    Google Scholar 

  194. Kuzmenko, Y. S., Stambolsky, D., Kern, F., Bochkov, V. N., Tkachuk, V. A., and Resink, T. J. (1998) Biochem. Biophys. Res. Commun., 246, 489–494.

    Google Scholar 

  195. Kuzmenko, Y. S., Kern, F., Bochkov, V. N., Tkachuk, V. A., and Resink, T. J. (1998) FEBS Lett., 434, 183–187.

    Google Scholar 

  196. Wyder, L., Vitaliti, A., Schneider, H., Hebbard, L. W., Moritz, D. R., Wittmer, M., Ajmo, M., and Klemenz, R. (2000) Cancer Res., 60, 4682–4688.

    Google Scholar 

  197. Tkachuk, V. A., Kuzmenko, Y. S., Resink, T. J., Stambolsky, D. V., and Bochkov, V. N. (1994) Mol. Pharmacol., 46, 1129–1137.

    Google Scholar 

  198. Bochkov, V. N., Tkachuk, V. A., Kuzmenko, Y. S., Borisova, Y. L., Buhler, F. R., and Resink, T. J. (1994) Mol. Pharmacol., 45, 262–270.

    Google Scholar 

  199. Kuzmenko, Y. S., Bochkov, V. N., Philippova, M. P., Tkachuk, V. A., and Resink, T. J. (1994) Biochem. J., 303, 281–287.

    Google Scholar 

  200. Bochkov, V. N., Tkachuk, V. A., Philippova, M. P., Stambolsky, D. V., Buhler, F. R., and Resink, T. J. (1996) Biochem. J., 317, 297–304.

    Google Scholar 

  201. Tkachuk, V. A., Bochkov, V. N., Philippova, M. P., Stambolsky, D. V., Kuzmenko, Y. S., Sidorova, M. V., Molokoedov, A. S., Spirov, V. G., and Resink, T. J. (1998) FEBS Lett., 421, 208–212.

    Google Scholar 

  202. Stambolsky, D. V., Kuzmenko, Y. S., Philippova, M. P., Bochkov, V. N., Bespalova, Z. D., Azmuko, A. A., Kashirina, N. M., Vlasik, T. N., Tkachuk, V. A., and Resink, T. J. (1999) Biochim. Biophys. Acta, 1416, 155–160.

    Google Scholar 

  203. Ross, R. (1995) Annu. Rev. Physiol., 57, 791–804.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Laboratory of Molecular Endocrinology, Institute of Experimental Cardiology, Russian Cardiology Research and Production Association, Ministry of Public Health of the Russian Federation, 3-ya Cherepkovskaya ul. 15a, Moscow, 121552, Russia

    D. B. Ivanov, M. P. Philippova & V. A. Tkachuk

Authors
  1. D. B. Ivanov
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. P. Philippova
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. V. A. Tkachuk
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ivanov, D.B., Philippova, M.P. & Tkachuk, V.A. Structure and Functions of Classical Cadherins. Biochemistry (Moscow) 66, 1174–1186 (2001). https://doi.org/10.1023/A:1012445316415

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/A:1012445316415

Search

Navigation