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Effects of mild heat shocks at young age on aging and longevity in Drosophila melanogaster

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Abstract

Young adult flies were submitted to heat shocks (37°C) ofvarious durations (5, 10, 20, 40 or 60 min daily) for 1, 2 or 3 weeks. Aslight longevity increase, in both sexes, was only observed with thelowest heat shock. Longer shocks had neutral or negative effects. Fliessubmitted to the procedure providing a longevity increase did not show adelayed behavioral aging but survived longer at 37°C thancontrol flies. This higher thermotolerance was not associated with anincreased hsp70 induction. The results are discussed in connection withhormesis and previous results showing that hypergravity, an other mildstress, increases longevity and delays behavioral aging: different mildstresses may have contrasting effects on aging and longevity.

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References

  • Dahlgaard J, Loeschke V, Michalak P and Justesen J (1998) Induced thermotolerance and associated expression of the heat-shock protein Hsp70 in adult Drosophila melanogaster. Funct Ecol 12: 786–793

    Google Scholar 

  • Feany MB and Bender WW (2000) A Drosophila model of Parkinson's disease. Nature 404: 394–398

    PubMed  Google Scholar 

  • Guerra D, Loeschke V and Cavicchi S (2000) Chromosomal and cytoplasmic analysis of heat shock resistance in natural populations of Drosophila melanogaster. Hereditas 132: 143–149

    Google Scholar 

  • Holloszy JO (1993) Exercise increases average longevity of female rats despite an increased food intake and no growth retardation. J Geront Biol Sci 48: B97-B100

    Google Scholar 

  • Khazaeli AA, Tatar M, Pletcher SD and Curtsinger JW (1997) Heat-induced longevity extension in Drosophila. I. Heat treatment, mortality, and thermotolerance. J Gerontol Biol Sci 52A: B48-B52

    Google Scholar 

  • Krebs RA and Loeschke V (1994a) Effects to exposure to short-term heat stress on fitness components in Drosophila melanogaster. J Evol Biol 7: 39–49

    Google Scholar 

  • Krebs RA and Loeschke V (1994b) Costs and benefits of activation of the heat-shock response in Drosophila melanogaster. Funct Ecol 8: 730–737

    Google Scholar 

  • Kuether K and Arking R (1999) Drosophila selected for extended longevity are more sensitive to heat shock. Age 22: 175–180

    Google Scholar 

  • Le Bourg E (1987) The rate of living theory. Spontaneous locomotor activity, aging and longevity in Drosophila melanogaster. Exp Gerontol 22: 359–369

    PubMed  Google Scholar 

  • Le Bourg E and Minois N (1997) Increased longevity and resistance to heat shock in Drosophila melanogaster flies exposed to hypergravity. C R Acad Sci Paris 320: 215–221

    PubMed  Google Scholar 

  • Le Bourg E and Minois N (1999) A mild stress, hypergravity exposure, postpones behavioral aging in Drosophila melanogaster. Exp Gerontol 34: 157–172

    PubMed  Google Scholar 

  • Le Bourg E, Lints FA, Fresquet N and Bullens P (1993) Review. Hypergravity, aging, and longevity in Drosophila melanogaster. Comp Biochem Physiol A 105: 389–396

    Google Scholar 

  • Le Bourg E, Minois N, Bullens P and Baret P (2000) A mild stress due to hypergravity exposure at young age increases longevity in Drosophila melanogaster males. Biogerontology 1: 145–155

    PubMed  Google Scholar 

  • Lithgow GJ (1996) Invertebrate gerontology: the age mutations of Caenorhabditis elegans. BioEssays 18: 809–815

    PubMed  Google Scholar 

  • Lithgow GJ, White TM, Melov S and Johnson TE (1995) Thermotolerance and extended life-span conferred by single-gene mutations and induced by thermal stress. Proc Natl Acad Sci USA 92: 7540–7544

    PubMed  Google Scholar 

  • Luckinbill LS (1998) Selection for longevity confers resistance to low-temperaure stress in Drosophla melanogaster. J Gerontol Biol Sci 53A: B147-B153

    Google Scholar 

  • Minois N (2000) Longevity and aging: beneficial effects of exposure to mild stress. Biogerontology 1: 15–29

    PubMed  Google Scholar 

  • Minois N and Le Bourg E (1999) Resistance to stress as a function of age in Drosophila melanogaster living in hypergravity. Mech Ageing Dev 109: 53–64

    PubMed  Google Scholar 

  • Minois N, Guinaudy MJ, Payre F and Le Bourg E (1999) HSP70 induction may explain the long-lasting resistance to heat of Drosophila melanogaster having lived in hypergravity. Mech Ageing Dev 109: 65–77

    PubMed  Google Scholar 

  • Miquel J, Lundgren PR and Binnard R (1972) Negative geotaxis and mating behavior in control and gamma-irradiated Drosophila. Droso Infor Serv 60: 48

    Google Scholar 

  • Rattan SIS (2000) Ageing, gerontogenes and hormesis. Ind J Exp Biol 38: 1–5

    Google Scholar 

  • Sacher GA (1963) Effects of X-rays on the survival of Drosophila imagoes. Physiol Zool 36: 295–311

    Google Scholar 

  • Service PM, Hutchinson EW, MacKinley MD and Rose MR (1985) Resistance to environmental stress in Drosophila melanogaster selected for postponed senescence. Physiol Zool 58: 380–389

    Google Scholar 

  • Shaw PJ, Cirelli C, Greenspan RJ and Tononi G (2000) Correlates of sleep and waking in Drosophila melanogaster. Science 287: 1834–1837

    PubMed  Google Scholar 

  • Velasquez JM, Sonoda S, Bugaisky G and Lindquist S (1983) Is the major Drosophila heat shock protein present in cells that have not been shocked? J Cell Biol 96: 286–290

    PubMed  Google Scholar 

  • Vieira C, Pasyukova EG, Zeng ZB, Hackett JB, Lyman RF, Mackay TFC (2000) Genotype-environment interaction for quantitative trait loci affecting life span in Drosophila melanogaster. Genetics 154: 213–227

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Laboratoire d'Éthologie et de Cognition Animale, F.R.E. C.N.R.S. no. 2382, Université Paul-Sabatier, 118 route de Narbonne, F-31062, Toulouse cedex 4, France (e-mail:

    Éric Le Bourg & Patrice Lucchetta

  2. Centre de Biologie du Développement, U.M.R. C.N.R.S. no. 5547, Université Paul-Sabatier, 118 route de Narbonne, F-31062, Toulouse cedex 4, France

    Philippe Valenti & François Payre

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  1. Éric Le Bourg
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  2. Philippe Valenti
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  3. Patrice Lucchetta
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  4. François Payre
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Le Bourg, É., Valenti, P., Lucchetta, P. et al. Effects of mild heat shocks at young age on aging and longevity in Drosophila melanogaster. Biogerontology 2, 155–164 (2001). https://doi.org/10.1023/A:1011561107055

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