Abstract
Heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP-A2/B1) is highly expressed during critical stages of lung development and carcinogenesis. To determine if the expression of hnRNP-A2/B1 is an informative biomarker in breast carcinogenesis, we analyzed hnRNP-A2/B1 overexpression by immunohistochemistry in archived specimens. Expression was detected in 48/85 (56.5%) primary invasive breast cancers and 7/72 (9.7%) specimens of normal breast tissue. Northern analysis of breast cancer cells also demonstrated higher level of hnRNP-A2/B1 expression compared to normal or transformed breast cells. Expression of hnRNP-A2/B1 in breast cancer cells was decreased by exposure to retinoids coordinately with decreased cell growth. These results warrant further evaluation of hnRNP-A2/B1 as a marker of breast carcinogenesis.
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Zhou, J., Allred, D., Avis, I. et al. Differential Expression of the Early Lung Cancer Detection Marker, Heterogeneous Nuclear Ribonucleoprotein-A2/B1 (hnRNP-A2/B1) in Normal Breast and Neoplastic Breast Cancer. Breast Cancer Res Treat 66, 217–224 (2001). https://doi.org/10.1023/A:1010631915831
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DOI: https://doi.org/10.1023/A:1010631915831