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Gallic acid: a Potent Inhibitor of Tetramethylbenzidine Peroxidation in Aqueous and Micellar Media

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Abstract

Gallic acid competitively inhibited 3,3",5,5"-tetramethylbenzidine peroxidation both in 0.01 M of phosphate buffer (pH 6.4) (K I= 13.3 μM) and in reversed aerosol OT micelles of different hydration degrees dispersed in heptane (K I= 21.3 to 29.3 μM). The average number of free radical particles terminated by one inhibitor molecule (f) was estimated to be 1.3 to 1.6 in aqueous buffer solutions and 1.08 to 2.72 in reversed micelles, depending on their hydration.

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Authors and Affiliations

  1. Institute of Bioorganic Chemistry, National Academy of Sciences of Belarus, Minsk, Republic of Belarus, 220141

    E. I. Karaseva, T. V. Nikiforova & D. I. Metelitsa

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  1. E. I. Karaseva
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  2. T. V. Nikiforova
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  3. D. I. Metelitsa
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Karaseva, E.I., Nikiforova, T.V. & Metelitsa, D.I. Gallic acid: a Potent Inhibitor of Tetramethylbenzidine Peroxidation in Aqueous and Micellar Media. Applied Biochemistry and Microbiology 37, 406–412 (2001). https://doi.org/10.1023/A:1010258206269

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