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Evidence for a Distinct Light-Induced Calcium-Dependent Potassium Current in Hermissenda Crassicornis

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Abstract

A model of phototransduction is developed as a first step toward a model for investigating the critical interaction of light and turbulence stimuli within the type B photoreceptor of Hermissenda crassicronis. The model includes equations describing phototransduction, release of calcium from intracellular stores, and other calcium regulatory mechanisms, as well as equations describing ligand-gating of a rhabdomeric sodium current. The model is used to determine the sources of calcium in the soma, whether calcium or IP3 is a plausible ligand of the light-induced sodium current, and whether the light-induced potassium current is equivalent to the calcium-dependent potassium current activated by light-induced calcium release. Simulations show that the early light-induced calcium elevation is due to influx through voltage-dependent channels, whereas the later calcium elevation is due to release from intracellular stores. Simulations suggest that the ligand of the fast, light-induced sodium current is IP3 but that there is a smaller, prolonged component of the light-induced sodium current that is activated by calcium. In the model, the calcium-dependent potassium current, located in the soma, is activated only slightly by light-induced calcium elevation, leading to the prediction that a calcium-dependent potassium current, active at resting potential, is located in the rhabdomere and is responsible for the light-induced potassium current.

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  1. Institute for Computational Sciences and Informatics, and Krasnow Institute for Advanced Study, George Mason University, Fairfax, VA, 22030

    K.T. Blackwell

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Blackwell, K. Evidence for a Distinct Light-Induced Calcium-Dependent Potassium Current in Hermissenda Crassicornis. J Comput Neurosci 9, 149–170 (2000). https://doi.org/10.1023/A:1008919924579

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