Abstract
Keeping in mind that the expression of vascular permeability factor (VPF) in astrocytic tumors has been related to tumor angiogenesis and peritumoral edema (PE), the aim of this study is to investigate the correlation between degree of VPF expression by tumor cells, and degree of PE and vascular endothelial surface (VES) in glioblastoma. Tumor tissue and neuroimaging data were studied in a series of 38 patients with glioblastoma. For each tumor, immunohistochemical and morphometric studies were performed in order to obtain a score of VPF expression, and a VES score, expressed as the CD-34 immunostained endothelial surface per each 1000 tumor cells. These parameters were related to the degree of PE. The results show that in glioblastomas there exist a clear correlation between the tumor-cell expression of VPF and VES, but we failed to obtain a significant correlation between degree of PE and degree of VES, or between degree of VPF expression and degree of PE. Our present results suggest that in glioblastomas, tumor angiogenesis is clearly related to the expression of VPF by tumor cells, but factors other than intratumoral presence of VPF may contribute to the development of PE.
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References
Bruce JN, Criscuolo GR, Merrill MJ, Moquin RR, Blacklock JB, Oldfield EH: Vascular permeability induced by protein product of malignant brain tumors: inhibition by dexamethasone. J Neurosurg 67: 880-884, 1987
Criscuolo GR, Merrill MJ, Oldfield EH: Further characterization of malignant glioma-derived vascular permeability factor. J Neurosurg 69: 254-262, 1988
Strugar JG, Criscuolo GR, Rothbart D, Harrington WN: Vascular endothelial growth/permeability factor expression in human glioma specimens: correlation with vasogenic brain edema and tumor-associated cysts. J Neurosurg 83: 682-689, 1995
Goldman CK, Bharara S, Palmer CA, Vitek J, Tsai JC, Weiss HL, Gillespie GY: Brain edema in meningiomas is associated with increased vascular endothelial growth factor expression. Neurosurgery 40: 1269-1277, 1997
Kalkanis SN, Carroll RS, Zhang J, Zamani M, Black PM: Correlation of vascular endothelial growth factor messenger RNA expression with peritumoral vasogenic cerebral edema in meningiomas. J Neurosurg 85: 1095-1101, 1996
Provias J, Claffey K, Del Aguila L, Nelson L, Feldkamp M, Guha A: Meningiomas: role of vascular endothelial growth factor/vascular permeability factor in angiogenesis and peritumoral edema. Neurosurgery 40: 1016-1026, 1997
Strugar JG, Rothbart D, Harrington W, Criscuolo GR: Vascular permeability factor in brain metastases: correlation with vasogenic brain edema and tumor angiogenesis. J Neurosurg 81: 560-566, 1994
Connolly DT, Heuvelman DM, Nelson R, Olander JV, Eppley L, Delfindo JJ, Siegel RM, Leimgruber RM, Feder J: Tumor vascular permeability factor stimulates endothelial cell growth and angiogenesis. J Clin Invest 84: 1470-1478, 1989
Ferrara N, Henzel WJ: Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells. Biochem Biophys Res Commun 161: 851-855, 1989
Gospodarowicz D, Lau K: Pituitary follicular cells secrete both vascular endothelial growth factor and follistatin. Biochem Biophys Res Commun 165: 292-298, 1989
Plate KH, Breier G, Weich HA, Risau W: Vascular endothelial growth factor is a potential tumor angiogenesis factor in human gliomas in vivo. Nature 359: 845-848, 1992
Weindel K, Moringlane JR, Marmé D, Weich HA: Detection and quantification of vascular endothelial growth factor/vascular permeability factor in brain tumor tissue and cyst fluid: the key to angiogenesis? Neurosurgery 35: 439-449, 1994
Kleihues P, Burger PC, Scheitauer BW: Histological Typing of Tumours of the Central Nervous System. Springer, New York, Berlin, Heidelberg, 1993
Bigner DD, McLendon RE, Bruner JM: Russell & Rubinstein's Pathology of Tumor of the Nervous System. Sixth ed. Vol. 1. Oxford University Press, Inc., 1998
Senger DR, Galli SJ, Dvorak AM, Perruzzi CA, Harvey VS, Dvorak HF: Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid. Science 219: 983-985, 1983
Klatzo I: Neuropathological aspects of brain edema. J Neuropathol Exp Neurol 26: 1-14, 1967
Chan PH, Fishman RA: The role of arachidonic acid in vasogenic brain edema. Fed Proc 43: 210-213, 1984
Fishman RA, Chan PH: Hypothesis: membrane phospholipid degradation and polyunsatured fatty acids play a key role in the pathogenesis of brain edema. Trans Am Neurol Assoc 106: 58-61, 1981
Pedrosa M: Biological significance of VEGF expression in intracranial meningiomas. Doctoral Thesis. Autonomous University, Madrid, Spain, 1999
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Vaquero, J., Zurita, M., Morales, C. et al. Expression of Vascular Permeability Factor in Glioblastoma Specimens: Correlation with Tumor Vascular Endothelial Surface and Peritumoral Edema. J Neurooncol 49, 49–55 (2000). https://doi.org/10.1023/A:1006453428508
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DOI: https://doi.org/10.1023/A:1006453428508