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Active and passive tobacco smoking and the risk of borderline and invasive ovarian cancer (United States)

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Abstract

Objective: A population-based case–control study was conducted to examine the hypothesis that active and passive tobacco smoking were associated with the risk of epithelial ovarian cancer. Methods: In-person interviews were obtained from 558 women with epithelial ovarian cancer (431 invasive, 127 borderline) and 607 population controls regarding active lifetime tobacco smoking, environmental tobacco smoke exposure in utero and during childhood, and other factors that may be related to the development of ovarian cancer. Results: No significant associations of ever or former tobacco smoking with the risk of invasive or borderline ovarian cancer were found, although long-term ex-smokers of 20 years or more were at significantly reduced risk of invasive cancer. Significant, positive dose–response relations of the number of cigarettes smoked per day and pack-years with the odds ratios for borderline cancer were evident. No association of active tobacco smoking with risk was found by histologic subtype of invasive ovarian cancer. Smokers were at significantly increased risk for borderline serous cystadenoma (OR: 1.91; 95% confidence intervals, CI: 1.09–3.34), but not for borderline mucinous cystadenoma. When we limited the analyses to current smokers, age-started smoking was significantly inversely related to the risk of invasive, but not borderline ovarian cancer. We found no association of gestational or childhood environmental tobacco smoke exposure with the risk of invasive or borderline ovarian cancer among never smokers. Conclusions: These findings do not support an association of active tobacco smoking with the risk of invasive ovarian cancer. An increased risk of borderline serous cystadenoma among smokers must be viewed with caution.

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References

  1. Zenzes MT (2000) Smoking and reproduction: gene damage to human gametes and embryos. Hum Reprod Update 6: 122-131.

    Google Scholar 

  2. Ness RB, Cramer DW, Goodman MT, et al. (2002) Infertility, fertility drugs, and ovarian cancer: a pooled analysis of case-control studies. Am J Epidemiol 155: 217-224.

    Google Scholar 

  3. Hecht SS (2002) Cigarette smoking and lung cancer: chemical mechanisms and approaches to prevention. Lancet Oncol 3: 461-469.

    Google Scholar 

  4. Zenzes MT, Reed TE, Casper RF (1997) Effects ofcigarette smoking and age on the maturation ofhuman oocytes. Hum Reprod 12: 1736-1741.

    Google Scholar 

  5. Modugno F, Ness RB, Cottreau C (2002) Cigarette smoking and the risk ofmucinous and nonmucinous epithelial ovarian cancer. Epidemiology 13: 467-471.

    Google Scholar 

  6. Green A, Purdie D, Bain C, Siskind V, Webb PM (2001) Cigarette smoking and risk ofepithelial ovarian cancer (Australia). Cancer Causes Control 12: 713-719.

    Google Scholar 

  7. Marchbanks PA, Wilson H, Bastos E, Cramer DW, Schildkraut JM, Peterson HB (2000) Cigarette smoking and epithelial ovarian cancer by histologic type. Obstet Gynecol 95: 255-260.

    Google Scholar 

  8. Doll R, Gray R, Hafner B, Peto R (1980) Mortality in relation to smoking: 22 years' observations on female British doctors. Br Med J 280: 967-971.

    Google Scholar 

  9. Whittemore AS, Wu ML, Paffenbarger RSJr, et al. (1988) Personal and environmental characteristics related to epithelial ovarian cancer: II. Exposures to talcum powder, tobacco, alcohol, and coffee. Am J Epidemiol 128: 1228-1240.

    Google Scholar 

  10. Polychronopoulou A, Tzonou A, Hsieh CC, et al. (1993) Reproductive variables, tobacco, ethanol, coffee and somatometry as risk factors for ovarian cancer. Int J Cancer 55: 402-407.

    Google Scholar 

  11. Franks AL, Lee NC, Kendrick JS, Rubin GL, Layde PM (1987) Cigarette smoking and the risk ofepithelial ovarian cancer. Am J Epidemiol 126: 112-117.

    Google Scholar 

  12. Stockwell HG, Lyman GH (1987) Cigarette smoking and the risk off emale reproductive cancer. Am J Obstet Gynecol 157: 35-40.

    Google Scholar 

  13. Engeland A, Andersen A, Haldorsen T, Tretli S (1996) Smoking habits and risk of cancers other than lung cancer: 28 years' follow-up of 26,000 Norwegian men and women. Cancer Causes Control 7: 497-506.

    Google Scholar 

  14. Kuper H, Titus-Ernstoff L, Harlow BL, Cramer DW (2000) Population based study of coffee, alcohol and tobacco use and risk of ovarian cancer. Int J Cancer 88: 313-318.

    Google Scholar 

  15. Hartge P, Schiffman MH, Hoover R, McGowan L, Lesher L, Norris HJ (1989) A case-control study of epithelial ovarian cancer. Am J Obstet Gynecol 161: 10-16.

    Google Scholar 

  16. Smith EM, Sowers MF, Burns TL (1984) Effects ofsmoking on the development off emale reproductive cancers. J Natl Cancer Inst 73: 371-376.

    Google Scholar 

  17. Tzonou A, Day NE, Trichopoulos D, et al. (1984) The epidemiology of ovarian cancer in Greece: a case-control study. Eur J Cancer Clin Oncol 20: 1045-1052.

    Google Scholar 

  18. Baron JA, Byers T, Greenberg ER, Cummings KM, Swanson M (1986) Cigarette smoking in women with cancers ofthe breast and reproductive organs. J Natl Cancer Inst 77: 677-680.

    Google Scholar 

  19. Nandakumar A, Anantha N, Dhar M, et al. (1995) A case-control investigation on cancer of the ovary in Bangalore, India. Int J Cancer 63: 361-365.

    Google Scholar 

  20. Mori M, Harabuchi I, Miyake H, Casagrande JT, Henderson BE, Ross RK (1988) Reproductive, genetic, and dietary risk factors for ovarian cancer. Am J Epidemiol 128: 771-777.

    Google Scholar 

  21. Byers T, Marshall J, Graham S, Mettlin C, Swanson M (1983) A case-control study of dietary and nondietary factors in ovarian cancer. J Natl Cancer Inst 71: 681-686.

    Google Scholar 

  22. Scully RE, Sobin LH (1999) Histological Typing of Ovarian Tumours. 2nd edn. New York: Springer.

    Google Scholar 

  23. Jauniaux E, Gulbis B, Acharya G, Thiry P, Rodeck C (1999) Maternal tobacco exposure and cotinine levels in fetal fluids in the first halfofpregnancy. Obstet Gynecol 93: 25-29.

    Google Scholar 

  24. Becker AB, Manfreda J, Ferguson AC, Dimich-Ward H, Watson WT, Chan-Yeung M (1999) Breast-feeding and environmental tobacco smoke exposure. Arch Pediatr Adolesc Med 153: 689-691.

    Google Scholar 

  25. Sorahan T, McKinney PA, Mann JR, et al. (2001) Childhood cancer and parental use oftobacco: findings from the interregional epidemiological study ofchildhood cancer (IRESCC). Br J Cancer 84: 141-146.

    Google Scholar 

  26. Goodman MT, Wu AH, Tung KH, et al. (2002) Association of dairy products, lactose, and calcium with the risk ofovarian cancer. Am J Epidemiol 156: 148-157.

    Google Scholar 

  27. Ries LAG, Eisner MP, Kosary CL, et al., eds. (2000) SEER Cancer Statistics Review, 1973-1997. Bathesda, MD: National Cancer Institute, NIH Pub no. 00-2789.

    Google Scholar 

  28. Oyama N, Johnson DB (1986) Hawaii Health Surveillance Program Survey Methods and Procedures. (Research &; Statistics report no. 54). Honolulu: Hawaii State Department of Health, Research and Statistics Office.

    Google Scholar 

  29. Pike MC, Peters RK, Cozen W, et al. (1997) Estrogen-progestin replacement therapy and endometrial cancer. J Natl Cancer Inst 89: 1110-1116.

    Google Scholar 

  30. Breslow NE, Day NE (1980) Statistical Methods in Cancer Research. The Analysis of Case-Control Studies. Vol. I, Lyon: IARC, (IARC scientific publication no. 32).

    Google Scholar 

  31. Scully RE (2000) Influence of origin of ovarian cancer on efficacy of screening. Lancet 355: 1028-1029.

    Google Scholar 

  32. Crayford TJ, Campbell S, Bourne TH, Rawson HJ, Collins WP (2000) Benign ovarian cysts and ovarian cancer: a cohort study with implications for screening. Lancet 355: 1060-1063.

    Google Scholar 

  33. Hull MG, North K, Taylor H, Farrow A, Ford WC (2000) Delayed conception and active and passive smoking: The Avon Longitudinal Study of Pregnancy and Childhood Study Team. Fertil Steril 74: 725-733.

    Google Scholar 

  34. Miller BA, Kolonel LN, Bernstein L, et al., eds. (1996) Racial/Ethnic Patterns of Cancer in the United States 1988-1992, Bethesda, MD: National Cancer Institute. NIH Pub. no. 96-4104.

    Google Scholar 

  35. Goodman MT, Howe HL, Tung K-H, et al. (2003) Incidence of ovarian cancer by race and ethnicity in the United States, 1992-1997. Cancer 97: 2676-2685.

    Google Scholar 

  36. Kolonel LN, Henderson BE, Hankin JH, et al. (2000) A multiethnic cohort study in Hawaii and Los Angeles: baseline characteristics. Am J Epidemiol 151: 346-357.

    Google Scholar 

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Authors and Affiliations

  1. Cancer Etiology Program, Cancer Research Center of Hawaii, University of Hawaii, 1236 Lauhala Street, Honolulu, HI, 96813, USA

    Marc T. Goodman

  2. Cancer Etiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HI, USA

    Ko-Hui Tung

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  1. Marc T. Goodman
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  2. Ko-Hui Tung
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Correspondence to Marc T. Goodman.

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Goodman, M.T., Tung, KH. Active and passive tobacco smoking and the risk of borderline and invasive ovarian cancer (United States). Cancer Causes Control 14, 569–577 (2003). https://doi.org/10.1023/A:1024828309874

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  • DOI: https://doi.org/10.1023/A:1024828309874

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