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Usefulness of Behavioral and Electrophysiological Studies in Transgenic Models of Alzheimer's Disease

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Abstract

Over the past several years researchers have engineered many transgenic models of Alzheimer's disease. Since loss of memory is one of the major hallmarks of the disorder, the phenotypic characterization of these animals has included both behavioral tests which aim to evaluate learning abilities, and electrophysiological studies to analyze synaptic transmission and long-term potentiation, a widely studied cellular model of learning and memory. These studies are fundamental for the design of novel therapies for the treatment and/or prevention of Alzheimer's disease.

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Authors and Affiliations

  1. Department of Psychiatry, New York University School of Medicine, New York, New York, 10016

    Antonino Sant'Angelo, Fabrizio Trinchese & Ottavio Arancio

  2. Dementia Research Center, Nathan Kline Institute for Psychiatric Research, Orangeburg, New York, 10962

    Antonino Sant'Angelo, Fabrizio Trinchese & Ottavio Arancio

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Sant'Angelo, A., Trinchese, F. & Arancio, O. Usefulness of Behavioral and Electrophysiological Studies in Transgenic Models of Alzheimer's Disease. Neurochem Res 28, 1009–1015 (2003). https://doi.org/10.1023/A:1023251005197

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