Skip to main content
SpringerLink
Log in

Cybernetic modeling of the cephalosporin C fermentation process by Cephalosporium acremonium

  • Published:
Biotechnology Letters Aims and scope Submit manuscript

Abstract

A cybernetic mathematical model has been developed to describe the production of cephalosporin C. In developing the model, diauxic behavior of substrate consumption, morphological differentiation of cells, and catabolite repression of cephalosporin C production by the preferred substrate, glucose, were considered. The proposed model was tested on the experimental data from the literature and could adequately describe the morphological differentiation of cells, the sequential utilization of carbon sources and the production of cephalosporin C. It could be a useful tool to optimize the production of cephalosporin C by Cephalosporium acremonium in batch, fed-batch or continuous operations.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Araujo MLGC, Oliveira RP, Giordano RC, Hokka CO (1996) Comparative studies on cephalosporin C production process with free and immobilized cells of Cephalosporium acremonium. Chem. Eng. Sci. 51: 2835–2840.

    Google Scholar 

  • Chu WBZ, Constantinides A (1988) Modeling, optimization, and computer control of the cephalosporin C fermentation process. Biotechnol. Bioeng. 32: 277–288.

    Google Scholar 

  • Cruz AJG, Silva AS, Araujo MLGC, Giordano RC, Hokka CO (1999) Modelling and optimization of the cephalosporin C production bioprocess in a fed–batch bioreactor with invert sugar as substrate. Chem. Eng. Sci. 54: 3137–3142.

    Google Scholar 

  • Kompala DS, Ramkrishna D, Tsao GT (1984) Cybernetic modeling of microbial growth on multiple substrates. Biotechnol. Bioeng. 26: 1272–1281.

    Google Scholar 

  • Matsumura M, Imanaka T, Yoshida T, Taguchi H (1978) Effect of glucose and methionine consumption rates on cephalosporin C production by Cephalosporium acremonium. J. Ferment. Technol. 56: 345–353.

    Google Scholar 

  • Matsumura M, Imanaka T, Yoshida T, Taguchi H (1980) Morphological differentiation in relation to cephalosporin C synthesis by Cephalosporium acremonium. J. Ferment. Technol. 58: 197–204.

    Google Scholar 

  • Matsumura M, Imanaka T, Yoshida T, Taguchi H (1981) Modeling of cephalosporin C production and its application to fed–batch culture. J. Ferment. Technol. 59: 115–123.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Chemical and Biological Engineering, Korea University, Anam-dong, Seongbuk-ku, Seoul, 136-701, Korea

    Byung Min Kim, Seung Wook Kim & Dae Ryook Yang

Authors
  1. Byung Min Kim
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Seung Wook Kim
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Dae Ryook Yang
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kim, B.M., Kim, S.W. & Yang, D.R. Cybernetic modeling of the cephalosporin C fermentation process by Cephalosporium acremonium . Biotechnology Letters 25, 611–616 (2003). https://doi.org/10.1023/A:1023080027754

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/A:1023080027754

Search

Navigation