Abstract
Gram-positive and Gram-negative bacteria induce different cytokine patterns in human mononuclear cells. We have seen that Gram-positives preferentially induce IL-12 and TNF-α, whereas Gram-negatives induce more IL-10, IL-6, and IL-8. In this study, we compared the capacity of these two groups of bacteria to induce PGE2. Monocytes stimulated with Gram-negative bacterial species induced much more PGE2 than did Gram-positive bacteria (5600 ± 330 vs. 1700 ± 670 pg/mL, p<;0.001). Blocking of COX-2 by NS398 abolished PGE2 production, but did not alter the cytokine patterns induced by Gram-positive and Gram-negative bacteria. We suggest that Gram-positive and Gram-negative bacteria may stimulate different innate effector functions; Gram-positive bacteria promoting cell-mediated effector functions whereas Gram-negative bacteria inducing mediators inhibiting the same.
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Hessle, C.C., Andersson, B. & Wold, A.E. Gram-Negative, but Not Gram-Positive, Bacteria Elicit Strong PGE2 Production in Human Monocytes. Inflammation 27, 329–332 (2003). https://doi.org/10.1023/B:IFLA.0000006700.41614.21
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DOI: https://doi.org/10.1023/B:IFLA.0000006700.41614.21