Skip to main content
SpringerLink
Log in

Glutathione-Dependent System of Antioxidant Defense in the Placenta in Preterm Delivery

  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Components of the antioxidant defense system in placental tissues were studied in women with normal pregnancy and full-term delivery and women with spontaneous abortions at 28-36 weeks. In women with spontaneous abortions glutathione peroxidase activity in placental tissues increased and the content of SH compounds decreased, which led to exhaustion of the antioxidant defense system. Glutathione-S-transferase activity also decreased, which attests to impaired detoxifying function of the placenta.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

REFERENCES

  1. A. V. Arutyunyan, E. E. Dubinina, and N. N. Zybina, Methods for Evaluation of Free Radical Oxidation and Antioxidant System, Ed. V. Kh. Khavinson [in Russian], St. Petersburg (2000).

  2. S. N. Vlasova and E. I. Shabunina, Lab. Delo, No. 8, 19–22 (1990).

  3. V. M. Moin, Ibid., No. 12, 724–727 (1986).

  4. V. M. Prokopenko, A. V. Arutyunyan, T. U. Kuz'minykh, et al., Vopr. Med. Khim., 41,No. 3, 53–56 (1995).

    Google Scholar 

  5. V. M. Sidel'nikova, Miscarriage [in Russian], Moscow (1986).

  6. R. Fried, Biochimie, 57,No. 5, 657–660 (1975).

    Google Scholar 

  7. J. A. Leff, M. A. Oppengard, T. J. Curied, et al., Free Radic. Biol. Med., 13,No. 2, 143–149 (1992).

    Google Scholar 

  8. O. H. Lowry, N. J. Rosebrough, A. L. Farr, and R. J. Randall, J. Biol. Chem., 193, 265–275 (1951).

    Google Scholar 

  9. J. Seldak and R. H. Lindsaoj, Anal. Biochem., 25, 192–205 (1968).

    Google Scholar 

  10. P. L. Zusterzeel, W. H. Peters, M. A. De Bruyn, et al., Obstet. Gynecol., 94,No. 6, H1033–1038 (1999).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. D. O. Ott Institute of Obstetrics and Gynecology, Russian Academy of Medical Sciences, St. Petersburg

    V. M. Prokopenko, G. K. Partsalis, N. G. Pavlova, S. O. Burmistrov & A. V. Arutyunyan

Authors
  1. V. M. Prokopenko
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. G. K. Partsalis
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. N. G. Pavlova
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. S. O. Burmistrov
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. A. V. Arutyunyan
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Prokopenko, V.M., Partsalis, G.K., Pavlova, N.G. et al. Glutathione-Dependent System of Antioxidant Defense in the Placenta in Preterm Delivery. Bulletin of Experimental Biology and Medicine 133, 442–443 (2002). https://doi.org/10.1023/A:1019845217485

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/A:1019845217485

Search

Navigation