Abstract
Autoantibodies directed to a variety of cellular antigens and organelles are a feature of autoimmune diseases. They have proven useful in a clinical setting to establish diagnosis, estimate prognosis, follow disease progression, alter therapy, and initiate new investigations. Cellular and molecular biologists have used autoantibodies as probes to identify molecules involved in key cellular processes. One of the most interesting sets of autoantibodies are those that target antigens within the mitotic apparatus (MA). The MA includes chromosomes, spindle microtubules and centrosomes. The identification, localization, function, and clinical relevance of MA autoantigens is the focus of this review. Abbreviations: ATP – adenosine triphosphate; CENP – centromere protein; CREST – calcinosis, Raynaud's phenomenon, esophageal dysmotility, sclerodactyly, telangiectasia; HMG – high mobility group; IB – intercellular bridge; IIF – indirect immunofluorescence; MAPs – microtubule associated proteins; NuMA – nuclear mitotic apparatus; NOR – nucleolar organizer; PBC – primary biliary cirrhosis; PM – polymyositis; Pol I, II, III – RNA polymerases; RA-rheumatoid arthritis; SLE – systemic lupus erythematosus; SS – Sjögren's syndrome; SSc – systemic sclerosis; topo – topoisomerase.
Similar content being viewed by others
References
Rattner JB (1990) BioEssays 13: 51–56
Pluta AF, Mackay AM, Ainztein AM, Goldberg IG & Earnshaw WC (1995) Science 270: 1591–1594
Wong AKC & Rattner JB (1992) Advances in Molecular and Cell Biology. J.A.I. Press Inc. Greenwich, CT, pp. 1–35
Willard HF (1996) Proc.Natl. Acad. Sci. USA 93: 6847–6850
Clarke L, Baum M, Marshall LG, Ngan VG & Steiner NC (1993) Cold Harbor Symp. Quant. Biol. 58: 687–695
Harrington JJ, Bokkelen GV, Mays RW, Gustashaw K & Willard HF (1997) Nature Genetics 15: 345–254
Rattner JB & Lin CC (1987) Genome 29: 588–593
Cooke CA, Bazett-Jones DP, Earnshaw WC & Rattner JB (1993) J. Cell Biol. 120: 1083–1091
Moroi Y, Peebles C, Fritzler MJ, Steigerwald J & Tan EM (1980) Proc. Natl. Acad. Sci. USA 77: 1627–1631
Tan EM, Rodnan GP, Garcia I, Moroi Y, Fritzler MJ & Peebles C (1980) Arthritis Rheum. 23: 617–625
Fritzler MJ & Kinsella TD (1980) Am. J. Med. 69: 520–525
Fritzler MJ (1993) J. Dermatol. 20: 257–268
Arnett FC (1995) Int. Rev. Immunol. 12: 107–128
Sullivan KF, Hechenberger M & Masri K (1994) J. Cell Biol. 127: 581–592
Earnshaw WC, Bordwell BJ, Marino C & Rothfield NF(1986) J. Clin. Invest. 77: 426–430
Muro Y, Sugimoto K, Okazaki T & Ohashi M (1990) J. Rheumatol. 17: 1042–1047
Verheijen R (1992) Mol. Biol. Rep. 16: 183–189
Matsumoto H, Masukata H, Muro Y, Nozaki N & Okazaki T (1989) J. Cell Biol. 109: 1963–1973
Yoda K, Kitagawa K, Matsumoto H, Muro Y & Okazaki T (1992) J. Cell Biol. 119: 1413–1427
Saitoh H, Tomkiel J, Cooke CA, Ratrie H, Maurer M, Rothfield NF & Earnshaw WC (1992) Cell 70: 1–20
Kingwell B & Rattner JB (1987) Chromosoma 95: 403–407
Vlachoyiannopoulos PG, Drosos AA, Wiik A et al. (1993) Br. J. Rheumatol. 32: 297–301
Belch JJF (1993) Br. J. Rheumatol. 32: 353–356
Maricq HR, Harper FE, Khan MM, Tan EM & LeRoy EC (1983) Clin. Exp. Rheumatol. 1: 195–205
Wigley FM, Wise RA, Miller R, Needleman BW & Spence RJ (1992) Arthritis Rheum. 35: 688–693
Makinen D, Fritzler MJ, Davis P & Sherlock S (1983) Arthritis Rheum. 26: 914–917
Lee S, Tsay GJ & Tsai R (1993) Ann. Rheum. Dis. 52: 586–589
Fritzler MJ, Pauls JD, Kinsella TD & Bowen TJ (1985) Clin. Immunol. Immunopathol. 36: 120–128
Arnett FC (1995) Int. Rev. Immunol. 12: 107–128
Yen TJ, Compton DA, Wise D, Zinkowski RP, Brinkley BR, Earnshaw WC & Cleveland DW (1991) EMBO J. 10: 1245–1254
Rattner JB, Rao A, Fritzler MJ, Valencia DW & Yen TJ (1993) Cell Motil. Cytoskelton 26: 214–226
Liao H, Winkfein RJ, Mack G, Rattner JB & Yen TJ (1995) J. Cell Biol. 130: 507–518
Saunders WS, Chue C, Goebl M, Craig C, Clark RF, Powers JA, Eissenberg JC, Elgin SCR, Rothfield NF & Earnshaw WC (1993) J. Cell Sci. 104: 573–582
Nicol N & Jeppesen P (1994) Chromosome Res. 2: 245–253
Furuta K, Chan EKL, Kiyosawa K, Reimer G, Luderschmidt C, & Tan EM (1997) Chromosoma 106: 11–19
Rattner JB, Rees J, Arnett FC, Reveille JD, Goldstein R & Fritzler MJ (1996) Arthritis Rheum. 39: 1355–1361
Earnshaw WC & Rothfield N (1985) Chromosoma 91: 313–321
Guldner HH, Lakomek HJ & Bautz FA (1984) Clin. Exp. Immunol. 58: 13–20
Haaf T, Dominguez-Steglich M & Schmid M (1990) Cytogenet. Cell Genet. 53: 40–51
Casiano CA, Humbel RL, Peebles C, Covini G & Tan EM (1995) J. Autoimmunity 8: 575–586
Rattner JB, Rees J, Whitehead CM, Casiano CA, Tan EM, Humbel R, Conrad K & Fritzler MJ (1997) Clin. Invest. Med. 20: 308–319
Thrower DA, Jordan MA & Wilson L (1996) Cell Motil Cytoskel. 35: 121–133
Wang JC (1985) Annu. Rev. Biochem. 54: 665–697
Rattner JB, Hendzel MJ, Furbee CS, Muller MT & Bazett-Jones DP (1996) J. Cell Biol. 134: 1097–1107
Hoffmann A, Heck MMS, Bordwell BJ, Rothfiel NF & Earnshaw WC (1989) Exp. Cell Res. 180: 409–418
Imai H, Furuta K, Landberg G, Kiyosawa K, Liu LF & Tan EM (1995) Clin. Cancer Res. 1: 417–422
Melcioni R, Bestango M, Sturni C et al. (1989) Clin. Exp. Immunol. 76: 184–189
Fujii T, Mimori T & Akizuki M (1995) Arthritis Rheum. 39: 1313–1315
Imai H, Fritzler MJ, Neri R, Bombardieri S, Tan EM & Chan EKL (1994) Mol. Biol. Rep. 19: 115–124
Fritzler MJ, von Muhlen CA, Toffoli SM, Staub HL & Laxer RM (1995) J. Rheumatol. 22 521–22 524
Okano Y & Medsger TA Jr. (1996) In: Peter JB & Shoenfeld Y (eds) Autoantibodies. Elsevier Science B.V. pp. 727–734
Rodriguez-Sanchez JL, Gelpi C, Juarez C & Hardin JA (1987) J. Immunol. 8: 2579–2584
Chan EKL, Imai H, Hamel JC & Tan EM (1991) J. Exp. Med. 174: 1239–1244
Dick T, Mierau R, Sternfeld R, Weiner EM & Genth E (1995) J. Rheumatol. 22: 67–72
Imai H, Ochs RL, Kiyosawa K, Furuta S, Nakamura RM & Tan EM (1992) Am. J. Pathol. 140: 859–870
Rodrigo RM, Rendon MC, Torreblanca J, Garcia-Herdugo G & Moreno FJ (1992) J. Cell Sci. 103: 1053–1063
Jantzen HM, Admon A, Bell SP & Tjian R (1990) Nature 344:830
Imai H, Kiyosawa K, Chan EKL & Tan EM (1993) Intervirology 35: 73–85
Kipnis RJ, Craft J & Hardin JA (1990) Arthritis Rheum. 33: 1431–1437
Reimer G, Rose KM, Scheer U & Tan EM (1987) J. Clin. Invest. 79: 65–72
Okano Y, Steen VD & Medsger TAJ (1993) Ann. Int. Med. 119: 1005–1013
Reimer G, Raska I, Tan EM & Scheer U (1987) Virchows Arch. B54: 131–143
Kuwana M, Kaburaki J, Mimori T, Tojo T & Homma M (1993) J. Clin. Invest. 91: 1399–1404
Kuwana M, Kaburaki J, Okano Y, Tojo T & Homma M (1994) Arthritis Rheum. 37: 75–83
Hirakata M, Okano Y, Pati U, Suwa A, Medsger TAJ, Hardin JA & Craft J (1993) J. Clin. Invest. 91: 2665–2672
Reimer G, Steen VD, Penning CA, Medsger TA & Tan EM (1988) Arthritis Rheum. 31: 525–532
Gautier T, Fomproix N, Masson C, AzumGélade M-C, Gas N & Hernandez-Verdun D (1994) Biol. Cell 82: 81–93
Rattner JB (1996) Chromosoma 101: 259–264
Ochs RL, Lischwe MA, Spohn WH & Busch H (1985) Biol. Cell 54: 123–134
Tan EM (1989) Adv. Immunol. 44: 93–151
Lischwe MA, Ochs RL, Reddy R, Cook RG, Yeoman LC, Tan EM, Reichlin M & Busch H (1985) J. Biol. Chem. 260:14 304–14 310
Reimer G, Pollard KM, Penning CA, Ochs RL, Lischwe MA, Busch H & Tan EM (1987) Arthritis Rheum. 30: 793–800
Reddy R, Tan EM, Henning D, Nohga K & Busch H (1983) J. Biol. Chem. 258: 1383–1386
Hultman P & Pollard KM (1996) In: Peter JB & Shoenfeld Y (eds) Autoantibodies. Elsevier Science B.V. pp. 253–259
Okano Y, Steen VD & Medsger TAJ (1992) Arthritis Rheum. 35: 95–100
Kuwana M, Kaburaki J, Okano Y, Tojo T & Homma M (1994) Arthritis Rheum. 37: 75–83
Kurzhals G, Meurer M, Krieg T & Reimer G (1990) J. Am. Acad. Dermatol. 23: 832–836
Sacks DG, Okano Y, Steen VD, Curtiss E, Shapiro LS & Medsger TA, Jr. (1996) J. Rheumatol. 23: 639–642
Takeuchi K, Turley SJ, Tan EM & Pollard KM (1995) J. Immunol. 154: 961–971
Hultman P, Turley SJ, Enestrom S, Lindh U & Pollard KM (1996) J. Autoimmun. 9: 139–149
Schluter C, Duchrow M, Wohlenberg et al. (1993). J. Cell Biol. 123: 513–522
Bloch DB, Rabkina D & Bloch KD (1995) Lab. Invest. 73: 366–371
Weston KM, Yeh ETH & Sy M (1987) J. Immunol. 139: 734–742
Kill IR (1996) J. Cell Sci. 109: 1253–1263
von Muhlen CA & Tan EM (1995) Semin. Arthritis Rheum. 24: 323–358
Blaschek M, Muller S & Youinou P (1993) J. Clin. Immunol. 13: 329–338
Yeo JP, Forer A & Toh B (1994) J. Cell Sci. 107: 1845–1851
Rattner JB & Fritzler MJ (1996) In: Peter JB & Shoenfeld Y (eds) Autoantibodies. Elsevier Science B.V. Amsterdam, pp. 153–160
Castell M (1996) In: Peter JB & Shoenfeld Y (eds) Autoantibodies. Elsevier Science B.V. Amsterdam, pp. 217–222
Andrade LEC, Chan EKL, Peebles CL & Tan EM (1996) Arthritis Rheum. 39: 1643–1653
Whitehead CM, Winkfein RJ, Fritzler MJ & Rattner JB (1996) Arthritis Rheum. 39: 1635–1642
Price CM, McCarty GA & Pettijohn DE (1984) Arthritis Rheum. 27: 774–779
Yang CH, Lambie EJ & Snyder M (1992) J. Cell Biol. 116: 1303–1317
Zeng C, He D, Berget SM & Brinkley BR (1994) Proc. Natl. Acad. Sci. USA 91: 1505–1509
Compton DA & Cleveland DW (1993) J. Cell Biol. 120: 947–957
Blangy A, Lane HA, Herin P, Harper M, Kress M & Nigg EA (1995) Cell 83: 1159–1169
Rattner JB (1992) Cell Motil. Cytoskel. 23: 231–235
Lind K, Hoier-Madsen M & Wiik A (1988) Infect. Immun. 56: 714–715
Gripenberg M & Helve T (1991) Scand. J. Rheumatol. 20: 104–109
Fritzler MJ & Rattner JB (1996) In: Peter JB & Shoenfeld Y (eds) Autoantibodies. Elsevier Science B.V. Amsterdam, pp. 501–506
Kalnins V (1992) The Centrosome. Academic Press, New York
Balczon R, Liming B & Zimmer WE (1994) J. Cell Biol. 124: 783–793
Bouckson-Castaing V, Moudjou M, Ferguson DJP, Mucklow S, Belkaid Y, Milon G & Crocker PR (1966) J. Cell Sci. 109: 179–190
Cimolai N, Mah D & Roland E (1994) J. Neurol. Neurosurg. Psychiatry 57: 638–639
Tuffanelli DL, McKeon F, Kleinsmith DM, Burnham TK & Kirschner M (1983) Arch. Dermatol. 119: 560–566
Sato S, Fujimoto M, Ihn H & Takehara K (1994) Dermatology 189: 23–26
Moroi Y, Murata I & Takeuchi A (1983) Clin. Immunol. Immunopathol. 29: 381–390
Osborn TG, Ryerse JS, Bauer NE & Urhahn JM (1986) Arthritis Rheum. 29: 142–146
Rattner JB, Martin L, Waisman DM, Johnstone SA & Fritzler MJ (1991) J. Immunol. 146: 2341–2344
Turksen K, Aubin JE & Kalnins VI (1982) Nature 298: 763–765
Covini G, Chan EKL, Nishioka M, Morshed SA, Reed SI & Tan EM (1997) 25: 75–80
Bernstein RM (1984) Lancet 1: 508–509
Martin L, Pauls JD, Ryan JP & Fritzler MJ (1993) Ann. Rheum. Dis. 52: 780–784
Fritzler MJ, Ayer LM, Gohill J, O'Connor C, Laxer RM & Humbel R (1987) J. Rheumatol. 14: 291–29
Kingwell B, Decoteau J, Fritzler MJ & Rattner JB (1987) Cell Motil. Cytoskelton 8: 360–367
Auer-Grumbach P & Achleitner B (1994) J. Rheumatol. 21: 1779–1781
McCarty GA, Valencia DW, Fritzler MJ & Barada FA (1981) N. Engl. J. Med. 305:703
Rattner JB, Wang T, Mack G, Martin L & Fritzler MJ (1992) Biochem. Cell Biol. 70: 1115–1122
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Rattner, J.B., Mack, G.J. & Fritzler, M.J. Autoantibodies to components of the mitotic apparatus. Mol Biol Rep 25, 143–155 (1998). https://doi.org/10.1023/A:1016523013819
Issue Date:
DOI: https://doi.org/10.1023/A:1016523013819