Skip to main content
Log in

Autoantibodies to components of the mitotic apparatus

Molecular Biology Reports Aims and scope Submit manuscript

Abstract

Autoantibodies directed to a variety of cellular antigens and organelles are a feature of autoimmune diseases. They have proven useful in a clinical setting to establish diagnosis, estimate prognosis, follow disease progression, alter therapy, and initiate new investigations. Cellular and molecular biologists have used autoantibodies as probes to identify molecules involved in key cellular processes. One of the most interesting sets of autoantibodies are those that target antigens within the mitotic apparatus (MA). The MA includes chromosomes, spindle microtubules and centrosomes. The identification, localization, function, and clinical relevance of MA autoantigens is the focus of this review. Abbreviations: ATP – adenosine triphosphate; CENP – centromere protein; CREST – calcinosis, Raynaud's phenomenon, esophageal dysmotility, sclerodactyly, telangiectasia; HMG – high mobility group; IB – intercellular bridge; IIF – indirect immunofluorescence; MAPs – microtubule associated proteins; NuMA – nuclear mitotic apparatus; NOR – nucleolar organizer; PBC – primary biliary cirrhosis; PM – polymyositis; Pol I, II, III – RNA polymerases; RA-rheumatoid arthritis; SLE – systemic lupus erythematosus; SS – Sjögren's syndrome; SSc – systemic sclerosis; topo – topoisomerase.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Rattner JB (1990) BioEssays 13: 51–56

    Google Scholar 

  2. Pluta AF, Mackay AM, Ainztein AM, Goldberg IG & Earnshaw WC (1995) Science 270: 1591–1594

    Google Scholar 

  3. Wong AKC & Rattner JB (1992) Advances in Molecular and Cell Biology. J.A.I. Press Inc. Greenwich, CT, pp. 1–35

    Google Scholar 

  4. Willard HF (1996) Proc.Natl. Acad. Sci. USA 93: 6847–6850

    Google Scholar 

  5. Clarke L, Baum M, Marshall LG, Ngan VG & Steiner NC (1993) Cold Harbor Symp. Quant. Biol. 58: 687–695

    Google Scholar 

  6. Harrington JJ, Bokkelen GV, Mays RW, Gustashaw K & Willard HF (1997) Nature Genetics 15: 345–254

    Google Scholar 

  7. Rattner JB & Lin CC (1987) Genome 29: 588–593

    Google Scholar 

  8. Cooke CA, Bazett-Jones DP, Earnshaw WC & Rattner JB (1993) J. Cell Biol. 120: 1083–1091

    Google Scholar 

  9. Moroi Y, Peebles C, Fritzler MJ, Steigerwald J & Tan EM (1980) Proc. Natl. Acad. Sci. USA 77: 1627–1631

    Google Scholar 

  10. Tan EM, Rodnan GP, Garcia I, Moroi Y, Fritzler MJ & Peebles C (1980) Arthritis Rheum. 23: 617–625

    Google Scholar 

  11. Fritzler MJ & Kinsella TD (1980) Am. J. Med. 69: 520–525

    Google Scholar 

  12. Fritzler MJ (1993) J. Dermatol. 20: 257–268

    Google Scholar 

  13. Arnett FC (1995) Int. Rev. Immunol. 12: 107–128

    Google Scholar 

  14. Sullivan KF, Hechenberger M & Masri K (1994) J. Cell Biol. 127: 581–592

    Google Scholar 

  15. Earnshaw WC, Bordwell BJ, Marino C & Rothfield NF(1986) J. Clin. Invest. 77: 426–430

    Google Scholar 

  16. Muro Y, Sugimoto K, Okazaki T & Ohashi M (1990) J. Rheumatol. 17: 1042–1047

    Google Scholar 

  17. Verheijen R (1992) Mol. Biol. Rep. 16: 183–189

    Google Scholar 

  18. Matsumoto H, Masukata H, Muro Y, Nozaki N & Okazaki T (1989) J. Cell Biol. 109: 1963–1973

    Google Scholar 

  19. Yoda K, Kitagawa K, Matsumoto H, Muro Y & Okazaki T (1992) J. Cell Biol. 119: 1413–1427

    Google Scholar 

  20. Saitoh H, Tomkiel J, Cooke CA, Ratrie H, Maurer M, Rothfield NF & Earnshaw WC (1992) Cell 70: 1–20

    Google Scholar 

  21. Kingwell B & Rattner JB (1987) Chromosoma 95: 403–407

    Google Scholar 

  22. Vlachoyiannopoulos PG, Drosos AA, Wiik A et al. (1993) Br. J. Rheumatol. 32: 297–301

    Google Scholar 

  23. Belch JJF (1993) Br. J. Rheumatol. 32: 353–356

    Google Scholar 

  24. Maricq HR, Harper FE, Khan MM, Tan EM & LeRoy EC (1983) Clin. Exp. Rheumatol. 1: 195–205

    Google Scholar 

  25. Wigley FM, Wise RA, Miller R, Needleman BW & Spence RJ (1992) Arthritis Rheum. 35: 688–693

    Google Scholar 

  26. Makinen D, Fritzler MJ, Davis P & Sherlock S (1983) Arthritis Rheum. 26: 914–917

    Google Scholar 

  27. Lee S, Tsay GJ & Tsai R (1993) Ann. Rheum. Dis. 52: 586–589

    Google Scholar 

  28. Fritzler MJ, Pauls JD, Kinsella TD & Bowen TJ (1985) Clin. Immunol. Immunopathol. 36: 120–128

    Google Scholar 

  29. Arnett FC (1995) Int. Rev. Immunol. 12: 107–128

    Google Scholar 

  30. Yen TJ, Compton DA, Wise D, Zinkowski RP, Brinkley BR, Earnshaw WC & Cleveland DW (1991) EMBO J. 10: 1245–1254

    Google Scholar 

  31. Rattner JB, Rao A, Fritzler MJ, Valencia DW & Yen TJ (1993) Cell Motil. Cytoskelton 26: 214–226

    Google Scholar 

  32. Liao H, Winkfein RJ, Mack G, Rattner JB & Yen TJ (1995) J. Cell Biol. 130: 507–518

    Google Scholar 

  33. Saunders WS, Chue C, Goebl M, Craig C, Clark RF, Powers JA, Eissenberg JC, Elgin SCR, Rothfield NF & Earnshaw WC (1993) J. Cell Sci. 104: 573–582

    Google Scholar 

  34. Nicol N & Jeppesen P (1994) Chromosome Res. 2: 245–253

    Google Scholar 

  35. Furuta K, Chan EKL, Kiyosawa K, Reimer G, Luderschmidt C, & Tan EM (1997) Chromosoma 106: 11–19

    Google Scholar 

  36. Rattner JB, Rees J, Arnett FC, Reveille JD, Goldstein R & Fritzler MJ (1996) Arthritis Rheum. 39: 1355–1361

    Google Scholar 

  37. Earnshaw WC & Rothfield N (1985) Chromosoma 91: 313–321

    Google Scholar 

  38. Guldner HH, Lakomek HJ & Bautz FA (1984) Clin. Exp. Immunol. 58: 13–20

    Google Scholar 

  39. Haaf T, Dominguez-Steglich M & Schmid M (1990) Cytogenet. Cell Genet. 53: 40–51

    Google Scholar 

  40. Casiano CA, Humbel RL, Peebles C, Covini G & Tan EM (1995) J. Autoimmunity 8: 575–586

    Google Scholar 

  41. Rattner JB, Rees J, Whitehead CM, Casiano CA, Tan EM, Humbel R, Conrad K & Fritzler MJ (1997) Clin. Invest. Med. 20: 308–319

    Google Scholar 

  42. Thrower DA, Jordan MA & Wilson L (1996) Cell Motil Cytoskel. 35: 121–133

    Google Scholar 

  43. Wang JC (1985) Annu. Rev. Biochem. 54: 665–697

    Google Scholar 

  44. Rattner JB, Hendzel MJ, Furbee CS, Muller MT & Bazett-Jones DP (1996) J. Cell Biol. 134: 1097–1107

    Google Scholar 

  45. Hoffmann A, Heck MMS, Bordwell BJ, Rothfiel NF & Earnshaw WC (1989) Exp. Cell Res. 180: 409–418

    Google Scholar 

  46. Imai H, Furuta K, Landberg G, Kiyosawa K, Liu LF & Tan EM (1995) Clin. Cancer Res. 1: 417–422

    Google Scholar 

  47. Melcioni R, Bestango M, Sturni C et al. (1989) Clin. Exp. Immunol. 76: 184–189

    Google Scholar 

  48. Fujii T, Mimori T & Akizuki M (1995) Arthritis Rheum. 39: 1313–1315

    Google Scholar 

  49. Imai H, Fritzler MJ, Neri R, Bombardieri S, Tan EM & Chan EKL (1994) Mol. Biol. Rep. 19: 115–124

    Google Scholar 

  50. Fritzler MJ, von Muhlen CA, Toffoli SM, Staub HL & Laxer RM (1995) J. Rheumatol. 22 521–22 524

    Google Scholar 

  51. Okano Y & Medsger TA Jr. (1996) In: Peter JB & Shoenfeld Y (eds) Autoantibodies. Elsevier Science B.V. pp. 727–734

  52. Rodriguez-Sanchez JL, Gelpi C, Juarez C & Hardin JA (1987) J. Immunol. 8: 2579–2584

    Google Scholar 

  53. Chan EKL, Imai H, Hamel JC & Tan EM (1991) J. Exp. Med. 174: 1239–1244

    Google Scholar 

  54. Dick T, Mierau R, Sternfeld R, Weiner EM & Genth E (1995) J. Rheumatol. 22: 67–72

    Google Scholar 

  55. Imai H, Ochs RL, Kiyosawa K, Furuta S, Nakamura RM & Tan EM (1992) Am. J. Pathol. 140: 859–870

    Google Scholar 

  56. Rodrigo RM, Rendon MC, Torreblanca J, Garcia-Herdugo G & Moreno FJ (1992) J. Cell Sci. 103: 1053–1063

    Google Scholar 

  57. Jantzen HM, Admon A, Bell SP & Tjian R (1990) Nature 344:830

  58. Imai H, Kiyosawa K, Chan EKL & Tan EM (1993) Intervirology 35: 73–85

    Google Scholar 

  59. Kipnis RJ, Craft J & Hardin JA (1990) Arthritis Rheum. 33: 1431–1437

    Google Scholar 

  60. Reimer G, Rose KM, Scheer U & Tan EM (1987) J. Clin. Invest. 79: 65–72

    Google Scholar 

  61. Okano Y, Steen VD & Medsger TAJ (1993) Ann. Int. Med. 119: 1005–1013

    Google Scholar 

  62. Reimer G, Raska I, Tan EM & Scheer U (1987) Virchows Arch. B54: 131–143

    Google Scholar 

  63. Kuwana M, Kaburaki J, Mimori T, Tojo T & Homma M (1993) J. Clin. Invest. 91: 1399–1404

    Google Scholar 

  64. Kuwana M, Kaburaki J, Okano Y, Tojo T & Homma M (1994) Arthritis Rheum. 37: 75–83

    Google Scholar 

  65. Hirakata M, Okano Y, Pati U, Suwa A, Medsger TAJ, Hardin JA & Craft J (1993) J. Clin. Invest. 91: 2665–2672

    Google Scholar 

  66. Reimer G, Steen VD, Penning CA, Medsger TA & Tan EM (1988) Arthritis Rheum. 31: 525–532

    Google Scholar 

  67. Gautier T, Fomproix N, Masson C, AzumGélade M-C, Gas N & Hernandez-Verdun D (1994) Biol. Cell 82: 81–93

    Google Scholar 

  68. Rattner JB (1996) Chromosoma 101: 259–264

    Google Scholar 

  69. Ochs RL, Lischwe MA, Spohn WH & Busch H (1985) Biol. Cell 54: 123–134

    Google Scholar 

  70. Tan EM (1989) Adv. Immunol. 44: 93–151

    Google Scholar 

  71. Lischwe MA, Ochs RL, Reddy R, Cook RG, Yeoman LC, Tan EM, Reichlin M & Busch H (1985) J. Biol. Chem. 260:14 304–14 310

    Google Scholar 

  72. Reimer G, Pollard KM, Penning CA, Ochs RL, Lischwe MA, Busch H & Tan EM (1987) Arthritis Rheum. 30: 793–800

    Google Scholar 

  73. Reddy R, Tan EM, Henning D, Nohga K & Busch H (1983) J. Biol. Chem. 258: 1383–1386

    Google Scholar 

  74. Hultman P & Pollard KM (1996) In: Peter JB & Shoenfeld Y (eds) Autoantibodies. Elsevier Science B.V. pp. 253–259

  75. Okano Y, Steen VD & Medsger TAJ (1992) Arthritis Rheum. 35: 95–100

    Google Scholar 

  76. Kuwana M, Kaburaki J, Okano Y, Tojo T & Homma M (1994) Arthritis Rheum. 37: 75–83

    Google Scholar 

  77. Kurzhals G, Meurer M, Krieg T & Reimer G (1990) J. Am. Acad. Dermatol. 23: 832–836

    Google Scholar 

  78. Sacks DG, Okano Y, Steen VD, Curtiss E, Shapiro LS & Medsger TA, Jr. (1996) J. Rheumatol. 23: 639–642

    Google Scholar 

  79. Takeuchi K, Turley SJ, Tan EM & Pollard KM (1995) J. Immunol. 154: 961–971

    Google Scholar 

  80. Hultman P, Turley SJ, Enestrom S, Lindh U & Pollard KM (1996) J. Autoimmun. 9: 139–149

    Google Scholar 

  81. Schluter C, Duchrow M, Wohlenberg et al. (1993). J. Cell Biol. 123: 513–522

    Google Scholar 

  82. Bloch DB, Rabkina D & Bloch KD (1995) Lab. Invest. 73: 366–371

    Google Scholar 

  83. Weston KM, Yeh ETH & Sy M (1987) J. Immunol. 139: 734–742

    Google Scholar 

  84. Kill IR (1996) J. Cell Sci. 109: 1253–1263

    Google Scholar 

  85. von Muhlen CA & Tan EM (1995) Semin. Arthritis Rheum. 24: 323–358

    Google Scholar 

  86. Blaschek M, Muller S & Youinou P (1993) J. Clin. Immunol. 13: 329–338

    Google Scholar 

  87. Yeo JP, Forer A & Toh B (1994) J. Cell Sci. 107: 1845–1851

    Google Scholar 

  88. Rattner JB & Fritzler MJ (1996) In: Peter JB & Shoenfeld Y (eds) Autoantibodies. Elsevier Science B.V. Amsterdam, pp. 153–160

    Google Scholar 

  89. Castell M (1996) In: Peter JB & Shoenfeld Y (eds) Autoantibodies. Elsevier Science B.V. Amsterdam, pp. 217–222

    Google Scholar 

  90. Andrade LEC, Chan EKL, Peebles CL & Tan EM (1996) Arthritis Rheum. 39: 1643–1653

    Google Scholar 

  91. Whitehead CM, Winkfein RJ, Fritzler MJ & Rattner JB (1996) Arthritis Rheum. 39: 1635–1642

    Google Scholar 

  92. Price CM, McCarty GA & Pettijohn DE (1984) Arthritis Rheum. 27: 774–779

    Google Scholar 

  93. Yang CH, Lambie EJ & Snyder M (1992) J. Cell Biol. 116: 1303–1317

    Google Scholar 

  94. Zeng C, He D, Berget SM & Brinkley BR (1994) Proc. Natl. Acad. Sci. USA 91: 1505–1509

    Google Scholar 

  95. Compton DA & Cleveland DW (1993) J. Cell Biol. 120: 947–957

    Google Scholar 

  96. Blangy A, Lane HA, Herin P, Harper M, Kress M & Nigg EA (1995) Cell 83: 1159–1169

    Google Scholar 

  97. Rattner JB (1992) Cell Motil. Cytoskel. 23: 231–235

    Google Scholar 

  98. Lind K, Hoier-Madsen M & Wiik A (1988) Infect. Immun. 56: 714–715

    Google Scholar 

  99. Gripenberg M & Helve T (1991) Scand. J. Rheumatol. 20: 104–109

    Google Scholar 

  100. Fritzler MJ & Rattner JB (1996) In: Peter JB & Shoenfeld Y (eds) Autoantibodies. Elsevier Science B.V. Amsterdam, pp. 501–506

    Google Scholar 

  101. Kalnins V (1992) The Centrosome. Academic Press, New York

    Google Scholar 

  102. Balczon R, Liming B & Zimmer WE (1994) J. Cell Biol. 124: 783–793

    Google Scholar 

  103. Bouckson-Castaing V, Moudjou M, Ferguson DJP, Mucklow S, Belkaid Y, Milon G & Crocker PR (1966) J. Cell Sci. 109: 179–190

    Google Scholar 

  104. Cimolai N, Mah D & Roland E (1994) J. Neurol. Neurosurg. Psychiatry 57: 638–639

    Google Scholar 

  105. Tuffanelli DL, McKeon F, Kleinsmith DM, Burnham TK & Kirschner M (1983) Arch. Dermatol. 119: 560–566

    Google Scholar 

  106. Sato S, Fujimoto M, Ihn H & Takehara K (1994) Dermatology 189: 23–26

    Google Scholar 

  107. Moroi Y, Murata I & Takeuchi A (1983) Clin. Immunol. Immunopathol. 29: 381–390

    Google Scholar 

  108. Osborn TG, Ryerse JS, Bauer NE & Urhahn JM (1986) Arthritis Rheum. 29: 142–146

    Google Scholar 

  109. Rattner JB, Martin L, Waisman DM, Johnstone SA & Fritzler MJ (1991) J. Immunol. 146: 2341–2344

    Google Scholar 

  110. Turksen K, Aubin JE & Kalnins VI (1982) Nature 298: 763–765

    Google Scholar 

  111. Covini G, Chan EKL, Nishioka M, Morshed SA, Reed SI & Tan EM (1997) 25: 75–80

  112. Bernstein RM (1984) Lancet 1: 508–509

    Google Scholar 

  113. Martin L, Pauls JD, Ryan JP & Fritzler MJ (1993) Ann. Rheum. Dis. 52: 780–784

    Google Scholar 

  114. Fritzler MJ, Ayer LM, Gohill J, O'Connor C, Laxer RM & Humbel R (1987) J. Rheumatol. 14: 291–29

    Google Scholar 

  115. Kingwell B, Decoteau J, Fritzler MJ & Rattner JB (1987) Cell Motil. Cytoskelton 8: 360–367

    Google Scholar 

  116. Auer-Grumbach P & Achleitner B (1994) J. Rheumatol. 21: 1779–1781

    Google Scholar 

  117. McCarty GA, Valencia DW, Fritzler MJ & Barada FA (1981) N. Engl. J. Med. 305:703

    Google Scholar 

  118. Rattner JB, Wang T, Mack G, Martin L & Fritzler MJ (1992) Biochem. Cell Biol. 70: 1115–1122

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Rattner, J.B., Mack, G.J. & Fritzler, M.J. Autoantibodies to components of the mitotic apparatus. Mol Biol Rep 25, 143–155 (1998). https://doi.org/10.1023/A:1016523013819

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/A:1016523013819

Navigation