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Smoking and the risk of leukemia, lymphoma, and multiple myeloma (Sweden)

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Abstract

While several epidemiologic studies have indicated a link between smoking and the risk of developing hema-tolymphoproliferative cancers (chiefly leukemias, lymphomas, and multiple myelomas), in particular myeloid leukemia, the role of tobacco in the etiology of these neoplasms remains unclear. To evaluate the potential impact of tobacco use on development of leukemia, lymphoma, and multiple myeloma, we conducted a cohort study of 334,957 Swedish construction workers using prospectively collected exposure-information with complete long-term follow-up. A total of 1,322 incident neoplasms occurred during the study period, 1971-91. We found no significant association between smoking status, number of cigarettes smoked, or duration of smoking and the risk of developing leukemias, lymphomas, or multiple myeloma. There was a suggestion of a positive association between smoking and the risk of developing Hodgkin's disease, although the rate ratios were not significantly elevated, except for young current smokers. No positive dose-risk trends emerged. Our study provides no evidence that smoking bears any major relationship to the occurrence of leukemias, non-Hodgkin's lymphomas, or multiple myeloma.

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Authors and Affiliations

  1. Department of Medical Epidemiology, Karolinska Institutet, Stockholm, Sweden

    Johanna Adami & Olof Nyrén

  2. Department of Statistics, Uppsala University Uppsala, Sweden

    Reinhold Bergström

  3. Harvard School of Public Health, Boston, USA

    Anders Ekbom

  4. National Board of Health and Welfare Stockholm, Sweden

    Göran Engholm & Anders Englund

  5. Department of Oncology, University Hospital Uppsala, Sweden

    Bengt Glimelius

Authors
  1. Johanna Adami
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  2. Olof Nyrén
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  3. Reinhold Bergström
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  5. Göran Engholm
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  7. Bengt Glimelius
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Adami, J., Nyrén, O., Bergström, R. et al. Smoking and the risk of leukemia, lymphoma, and multiple myeloma (Sweden). Cancer Causes Control 9, 49–56 (1998). https://doi.org/10.1023/A:1008897203337

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