Total Synthesis of (+)-Dactylolide

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Org. Lett., 7 (14), 3053 -3056, 2005. 10.1021/ol051040g S1523-7060(05)01040-0
Web Release Date: June 7, 2005

Total Synthesis of (+)-Dactylolide

Carina C. Sanchez and Gary E. Keck*

Department of Chemistry, University of Utah, 315 South 1400 East RM 2020, Salt Lake City, Utah 84112-0850

keck@chemistry.utah.edu

Received May 5, 2005

Abstract:

The development of an approach leading to the total synthesis of dactylolide is described. The key features of this route include a catalytic asymmetric allylation, a diastereoselective pyran annulation, and a Horner-Wadsworth-Emmons macrocyclization.

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