An Improved Procedure for the
Three-Component Synthesis of Highly
Substituted Pyridines Using Ionic Liquid
Brindaban C. Ranu,*Ranjan Jana, andS. Sowmiah
Department of Organic Chemistry, Indian Association for the
Cultivation of Science, Jadavpur, Kolkata 700 032, India
ocbcr@iacs.res.in
Received January 4, 2007
Abstract:
A basic ionic liquid, [bmIm]OH, efficiently promotes a one-pot, three-component condensation of aldehydes, malononitrile, and thiophenols to produce highly substituted pyridines in high yields at room temperature. This reaction does
not involve any hazardous organic solvent and toxic catalyst.
The ionic liquid is recovered and recycled for subsequent
reactions.
