Web Release Date: March 16,
Organocatalysis in Radical Chemistry. Enantioselective 
-Oxyamination of
Aldehydes
Department of Chemistry, North Dakota State University, Fargo, North Dakota 58105
Received December 22, 2006
Abstract:
We have developed an efficient radical -oxyamination reaction using chiral organocatalysts. The reaction can be carried out with inexpensive SET reagents, and a reasonably broad substrate scope has been established. Good to high enantioselectivity for the -oxygenated products are obtained using 20 mol % of the catalyst. The methodology reported in this work adds to the repertoire of asymmetric radical reactions that can be conducted using organocatalysts.
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