Web Release Date: February 23,
Total Synthesis of Jerangolid D
í Pospí
il and
n E. Markó*
Département de Chimie, Bâtiment Lavoisier, Université catholique de Louvain, Place Louis Pasteur 1, B-1348 Louvain-la-Neuve, Belgium
Received January 4, 2007
Abstract:
A short and convergent synthesis of jerangolid D is described. As key steps, a Blaise reaction is employed to construct the lactone ring, a diastereoselective multicomponent Sakurai condensation leads to the dihydropyran ring, and the skipped diene is assembled using a modified Julia olefination.
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