Web Release Date: December 21,
Catalytic Enantioselective Allenylation Reactions of Aldehydes with Tethered Bis(8-quinolinolato) (TBOx) Chromium Complex
Department of Chemistry, The University of Chicago, 5735 South Ellis Avenue, Chicago, Illinois 60637
Received November 12, 2006
Abstract:
The utility of the new class of chiral ligand, tethered bis(8-quinolinol) (TBOxH), is further explored. Its chromium complex, TBOxCr(III)Cl, effectively catalyzes the asymmetric allenylation reactions of various aldehydes at room temperature with high yields (up to 91%) and high enantioselectivities (up to 97% ee). The scope of the present method is shown to be wide, and this method represents an efficient access to chiral 
-allenic alcohols.
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