J. Am. Chem. Soc., 128 (32), 10589 -10595, 2006. 10.1021/ja0612549 S0002-7863(06)01254-6
Web Release Date: July 22, 2006

Copyright © 2006 American Chemical Society

Intramolecular Diels-Alder/1,3-Dipolar Cycloaddition Cascade of 1,3,4-Oxadiazoles

Gregory I. Elliott, James R. Fuchs, Brian S. J. Blagg, Hayato Ishikawa, Houchao Tao, Z.-Q. Yuan, and Dale L. Boger*

Contribution from the Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037

boger@scripps.edu

Received February 21, 2006

Abstract:

Full details of a systematic exploration of the intramolecular [4 + 2]/[3 + 2] cycloaddition cascade of 1,3,4-oxadiazoles are disclosed in which the scope and utility of the reaction are defined.

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