Web Release Date: June 18,
Asymmetric 1,4-Hydrosilylations of 
,
-Unsaturated Esters
Department of Chemistry & Biochemistry, University of California, Santa Barbara, California 93106
Received February 17, 2004
Abstract:
Complexing catalytic amounts of CuH with a nonracemic JOSIPHOS or SEGPHOS ligand, together with stoichiometric PMHS, leads to exceedingly efficient and highly enantioselective 1,4-reductions of ,-disubstituted enoates and lactones. An unprecedented substrate-to-ligand ratio of 7700:1 for this type of reaction is documented.
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