Web Release Date: October 28,
Lewis Acid-Mediated Selective Chlorinations of Silyl Enolate
Department of Chemistry, University of Chicago, 5735 South Ellis Avenue, Chicago, Illinois 60637
Received July 28, 2004
Abstract:
A new method involving efficient, widely applicable, and highly selective 
-chlorination of simple silyl enolate with Lewis acid and an ,-dichloro-1,3-dicarbonyl controller unit was reported. Diastereoselectivity and enantioselectivity of the reaction were investigated. High reactivity and selectivity were achieved by using ,-dichlorinated malonic ester.
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