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Alterations in resting-state functional activity and connectivity for major depressive disorder appetite and weight disturbance phenotypes

Published online by Cambridge University Press:  07 June 2022

Mayron Piccolo Open the ORCID record for Mayron Piccolo [Opens in a new window] ,
Emily L. Belleau ,
Laura M. Holsen ,
Madhukar H. Trivedi ,
Ramin V. Parsey ,
Patrick J. McGrath ,
Myrna M. Weissman ,
Diego A. Pizzagalli  and
Kristin N. Javaras Open the ORCID record for Kristin N. Javaras [Opens in a new window]
Mayron Piccolo
Affiliation:
McLean Hospital, Belmont, MA 02478, USA Department of Psychiatry, Harvard Medical School, Boston, MA 02115, USA
Emily L. Belleau
Affiliation:
McLean Hospital, Belmont, MA 02478, USA Department of Psychiatry, Harvard Medical School, Boston, MA 02115, USA
Laura M. Holsen
Affiliation:
Department of Psychiatry, Harvard Medical School, Boston, MA 02115, USA Division of Women's Health, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA Department of Psychiatry, Brigham and Women's Hospital, Boston, MA 02115, USA
Madhukar H. Trivedi
Affiliation:
Division of Mood Disorders, University of Texas, Southwestern Medical Center, Dallas, TX 75390, USA
Ramin V. Parsey
Affiliation:
Neuroscience Institute, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY 11733, USA
Patrick J. McGrath
Affiliation:
New York State Psychiatric Institute & Department of Psychiatry, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
Myrna M. Weissman
Affiliation:
New York State Psychiatric Institute & Department of Psychiatry, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
Diego A. Pizzagalli
Affiliation:
McLean Hospital, Belmont, MA 02478, USA Department of Psychiatry, Harvard Medical School, Boston, MA 02115, USA
Kristin N. Javaras*
Affiliation:
McLean Hospital, Belmont, MA 02478, USA Department of Psychiatry, Harvard Medical School, Boston, MA 02115, USA
*
Author for correspondence: Kristin N. Javaras, E-mail: kjavaras@mclean.harvard.edu
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Abstract

Background

Major depressive disorder (MDD) is often accompanied by changes in appetite and weight. Prior task-based functional magnetic resonance imaging (fMRI) findings suggest these MDD phenotypes are associated with altered reward and interoceptive processing.

Methods

Using resting-state fMRI data, we compared the fractional amplitude of low-frequency fluctuations (fALFF) and seed-based connectivity (SBC) among hyperphagic (n = 77), hypophagic (n = 66), and euphagic (n = 42) MDD groups and a healthy comparison group (n = 38). We examined fALFF and SBC in a mask restricted to reward [nucleus accumbens (NAcc), putamen, caudate, ventral pallidum, and orbitofrontal cortex (OFC)] and interoceptive (anterior insula and hypothalamus) regions and also performed exploratory whole-brain analyses. SBC analyses included as seeds the NAcc and also regions demonstrating group differences in fALFF (i.e. right lateral OFC and right anterior insula). All analyses used threshold-free cluster enhancement.

Results

Mask-restricted analyses revealed stronger fALFF in the right lateral OFC, and weaker fALFF in the right anterior insula, for hyperphagic MDD v. healthy comparison. We also found weaker SBC between the right lateral OFC and left anterior insula for hyperphagic MDD v. healthy comparison. Whole-brain analyses revealed weaker fALFF in the right anterior insula, and stronger SBC between the right lateral OFC and left precentral gyrus, for hyperphagic MDD v. healthy comparison. Findings were no longer significant after controlling for body mass index, which was higher for hyperphagic MDD.

Conclusions

Our results suggest hyperphagic MDD may be associated with altered activity in and connectivity between interoceptive and reward regions.

Keywords

AppetiteeatingfMRImajor depressive disorderweight change
Type
Original Article
Information
Psychological Medicine , Volume 53 , Issue 10 , July 2023 , pp. 4517 - 4527
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Copyright
Copyright © The Author(s), 2022. Published by Cambridge University Press

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