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Soil-transmitted helminthiasis among mothers and their pre-school children on Unguja Island, Zanzibar with emphasis upon ascariasis

Published online by Cambridge University Press:  08 September 2008

J. R. STOTHARD*
Affiliation:
Department of Zoology, Natural History Museum, Cromwell Road, London SW7 5BD, UK
E. IMISON
Affiliation:
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
M. D. FRENCH
Affiliation:
Schistosomiasis Control Initiative, Department of Infectious Disease Epidemiology, Imperial College London, London W2 1PG, UK
J. C. SOUSA-FIGUEIREDO
Affiliation:
Department of Zoology, Natural History Museum, Cromwell Road, London SW7 5BD, UK
I. S. KHAMIS
Affiliation:
Helminth Control Laboratory Unguja, Ministry of Health and Social Welfare, Zanzibar, Tanzania
D. ROLLINSON
Affiliation:
Department of Zoology, Natural History Museum, Cromwell Road, London SW7 5BD, UK
*
*Corresponding author: Department of Zoology, Natural History Museum, Cromwell Road, London SW7 5BD, UK. Tel: +44 2079425490. Fax: +44 2079425518. E-mail: r.stothard@nhm.ac.uk

Summary

Soil-transmitted helminthiasis (STH) is a scourge to the health and well-being of infants and pre-schoolchildren throughout many parts of sub-Saharan Africa. To improve maternal and child health, regular de-worming is recommended and often delivered from mother and child health (MCH) clinics, yet there have been few studies monitoring the progress and impact of interventions on local levels of disease. A cross-sectional parasitological survey, supplemented with questionnaires, was therefore conducted across 10 Ungujan villages examining mothers (n=322) and their pre-school children (n=359). Within children, mean prevalence of ascariasis, trichuriasis and hookworm was 8·6% (95% CI 5·5–11·8), 18·9% (95% CI 14·5–23·4) and 1·7% (95% CI 0·2–3·5) while in mothers mean prevalence was 6·7% (95% CI 3·7–9·7), 11·9% (95% CI 8·0–15·8) and 1·9% (95% CI 0·2–3·5), respectively. There was, however, significant spatial heterogeneity of STH by village, 2 villages having much elevated levels of infection, although general access to anthelminthics and utilization of village MCH clinics was good. Levels of parasite aggregation (k) were determined and a multilevel logistic regression model identified access to a household latrine [OR=0·56 (95% CI 0·32–0·99)] and having an infected household member [OR=3·72 (95% CI 2·22–6·26)] as observed risk factors. To further investigate worm burdens of Ascaris lumbricoides, adult worms were expelled using Combantrin® and measured. A negative relationship between mean worm burden and mean worm mass was found. Villages in the north of Unguja represent locations where there is elevated prevalence of both ascariasis and trichuriasis and it appears that local factors are particularly favourable for transmission of these helminths. From a perspective of control, in such locations, intervention efforts should be stepped up and greater efforts placed upon improving household sanitation.

Type
Original Articles
Copyright
Copyright © 2008 Cambridge University Press

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