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The in vivo and in vitro transmission ratio distortion of one complete and two partial t haplotypes in mice

Published online by Cambridge University Press:  14 April 2009

William Garside ,
Christine Ruangvoravat ,
Patricia Dolan  and
Nina Hillman
William Garside
Affiliation:
Department of Biology, Temple University, Philadelphia, PA, 19122, USA
Christine Ruangvoravat
Affiliation:
Department of Biology, Temple University, Philadelphia, PA, 19122, USA
Patricia Dolan
Affiliation:
Department of Biology, Temple University, Philadelphia, PA, 19122, USA
Nina Hillman
Affiliation:
Department of Biology, Temple University, Philadelphia, PA, 19122, USA

Summary

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The effects of different types of insemination (normal and delayed matings and in vitro fertilization) on the transmission ratio distortion (TRD) of three t haplotypes were determined. The tw73 haplotype which contains all of the loci known to affect TRD is transmitted at equivalent frequencies in normal matings and in in vitro fertilizations (0·84 and 0·85, respectively) but at a significantly lower frequency (0·62) in delayed matings. The distal partial th18 haplotype is transmitted at equivalent frequencies in all types of insemination (0·66 to 0·70) while the proximal partial tw18 haplotype is transmitted in Mendelian frequencies in normal matings and in in vitro inseminations but at a significantly lower frequency in delayed matings. The results are discussed with reference to the current genetic model for transmission ratio distortion.

Type
Research Article
Information
Genetics Research , Volume 57 , Issue 2 , April 1991 , pp. 153 - 157
Copyright
Copyright © Cambridge University Press 1991

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