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An allele at the triose phosphate isomerase, Tpi-1 locus on chromosome 6 recovered from feral mice

Published online by Cambridge University Press:  14 April 2009

Grahame Bulfield ,
Simon T. Ball  and
Josephine Peters
Grahame Bulfield*
Affiliation:
Gene Expression Group, AFRC Institute of Animal Physiology and Genetics Research, Edinburgh Research Station, Roslin, Midlothian EH25 9PS, UK
Simon T. Ball
Affiliation:
MRC Radiobiology Unit, Chilton, Oxon, OX11 0RD, UK
Josephine Peters
Affiliation:
MRC Radiobiology Unit, Chilton, Oxon, OX11 0RD, UK
*
* Corresponding author.

Summary

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An animal with low erythrocyte triose phosphate isomerase (TPI) activity was found amongst mice trapped on a farm in Leicestershire. The low TPI activity was caused by the segregation of a single co-dominant gene which also affected the Km for glyceraldehyde-3-phosphate and heat stability of the enzyme. We designate the gene Tpi-1, the structural locus for TPI, with the a allele in the common inbred strains and the b allele derived from the wild-caught mouse. Tpi-1 was known to be on chromosome 6 by somatic cell techniques and, as shown in a preliminary report (Peters & Bulfield, 1984), we have confirmed and extended this finding using three chromosome-6 marker genes giving the order: Sig-28-Lc-11-Miwh-16-Tpi-1.

Type
Research Article
Information
Genetics Research , Volume 50 , Issue 3 , December 1987 , pp. 239 - 243
Copyright
Copyright © Cambridge University Press 1987

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