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Clinical consequences of contaminated blood cultures in adult hospitalized patients at an institution utilizing a rapid blood-culture identification system

Published online by Cambridge University Press:  10 December 2020

Sidra Liaquat ,
Lorena Baccaglini ,
Gleb Haynatzki ,
Sharon J. Medcalf  and
Mark E. Rupp Open the ORCID record for Mark E. Rupp [Opens in a new window]
Sidra Liaquat*
Affiliation:
Department of Epidemiology, College of Public Health, University of Nebraska Medical Center, Omaha, Nebraska
Lorena Baccaglini
Affiliation:
Department of Epidemiology, College of Public Health, University of Nebraska Medical Center, Omaha, Nebraska
Gleb Haynatzki
Affiliation:
Department of Biostatistics, College of Public Health, University of Nebraska Medical Center, Omaha, Nebraska
Sharon J. Medcalf
Affiliation:
Department of Epidemiology, College of Public Health, University of Nebraska Medical Center, Omaha, Nebraska
Mark E. Rupp*
Affiliation:
Division of Infectious Diseases, University of Nebraska Medical Center, Omaha, Nebraska
*
Author for correspondence: Mark E. Rupp, E-mail: merupp@unmc.edu. Or Sidra Liaquat, E-mail: sidra.liaquat@unmc.edu
Author for correspondence: Mark E. Rupp, E-mail: merupp@unmc.edu. Or Sidra Liaquat, E-mail: sidra.liaquat@unmc.edu
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Abstract

Objective:

To assess the clinical impact of contaminated blood cultures in hospitalized patients during a period when rapid diagnostic testing using a FilmArray Blood Culture Identification (BCID) panel was in use.

Design:

Retrospective cohort study.

Setting:

Single academic medical center.

Participants:

Patients who had blood culture(s) performed during an admission between June 2014 and December 2016.

Methods:

Length of hospital stay and days of antibiotic therapy were assessed in relation to blood-culture contamination using generalized linear models with univariable and multivariable analyses.

Results:

Among 11,474 patients who had blood cultures performed, the adjusted mean length of hospital stay for patients with contaminated blood-culture episodes (N = 464) was 12.3 days (95% confidence interval [CI], 11.4–13.2) compared to 11.5 days (95% CI, 11.0–11.9) for patients (N = 11,010) with negative blood-culture episodes (P = .032). The adjusted mean durations of antibiotic therapy for patients with contaminated and negative blood-culture episodes were 6.0 days (95% CI, 5.3–6.7) and 5.2 days (95% CI, 4.9–5.4), respectively (P = .011).

Conclusions:

Despite the use of molecular-based, rapid blood-culture identification, contamination of blood cultures continues to result in prolonged hospital stay and unnecessary antibiotic therapy in hospitalized patients.

Type
Original Article
Information
Infection Control & Hospital Epidemiology , Volume 42 , Issue 8 , August 2021 , pp. 978 - 984
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Copyright
© The Author(s), 2020. Published by Cambridge University Press on behalf of The Society for Healthcare Epidemiology of America

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