Hostname: page-component-8448b6f56d-sxzjt Total loading time: 0 Render date: 2024-04-18T12:16:27.163Z Has data issue: false hasContentIssue false
  • English
  • Français

The association between birthweight and grandparental type 2 diabetes and cardiovascular disease in a multiethnic population

Published online by Cambridge University Press:  18 November 2019

Marte Kjøllesdal Open the ORCID record for Marte Kjøllesdal [Opens in a new window] ,
Anne Karen Jenum ,
Øyvind Næss  and
Line Sletner
Marte Kjøllesdal*
Affiliation:
Health Services Research, Norwegian Institute of Public Health, Oslo, Norway Department of Community Medicine and Global Health, Institute of Health and Society, University of Oslo, Oslo, Norway
Anne Karen Jenum
Affiliation:
Department of General Medicine, General Practice Research Unit (AFE), Institute of Health and Society, University of Oslo, Oslo, Norway
Øyvind Næss
Affiliation:
Department of Community Medicine and Global Health, Institute of Health and Society, University of Oslo, Oslo, Norway
Line Sletner
Affiliation:
Department of Pediatric and Adolescents Medicine, Akershus University Hospital, Akershus, Norway Institute of Clinical Medicine, University of Oslo, Oslo, Norway
*
Address for correspondence: Marte Kjøllesdal, Norwegian Institute of Public Health, Health Services Research, Oslo, Norway. Email: MarteKarolineRaberg.Kjollesdal@fhi.no
Get access Rights & Permissions [Opens in a new window]

Abstract

Intergenerational links of chronic disease have been suggested, as birthweight (BW) is associated with cardiovascular disease (CVD) and type 2 diabetes (T2D) in both parents and grandparents. However, most studies investigating these relationships have used relatively homogenous, white, majority populations. This study aimed to investigate the association between BW and CVD and T2D in a multiethnic population, that is, where the parents and grandparents often developed in a different environment from that where the child was born. Participants were women from a population-based cohort study of pregnant women (STORK Groruddalen), attending Child Health Clinics for antenatal care in three administrative city districts in Oslo, Norway, 2008–2010. Information about socioeconomic and lifestyle factors were collected among mothers and fathers. Parents reported history of CVD or T2D among grandparents. In logistic regressions, higher BW z-scores were associated with lower odds of T2D among maternal (OR 0.71 (95% CI 0.53, 0.97) and paternal (0.68 (0.49, 0.94) grandmothers after adjustments for parental and grandmothers’ characteristics. BW was not associated with CVD, but the association in maternal grandfathers was borderline significant. Our results indicate intergenerational transmission of chronic diseases like T2D in a multiethnic population.

Keywords

birthweightdiabetescardiovascular diseasegrandparents
Type
Original Article
Information
Journal of Developmental Origins of Health and Disease , Volume 11 , Issue 4 , August 2020 , pp. 403 - 409
Copyright
© Cambridge University Press and the International Society for Developmental Origins of Health and Disease 2019

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Barker, DJThe developmental origins of chronic adult disease. Acta Paediatr Suppl. 2004; 93, 26–33.10.1111/j.1651-2227.2004.tb00236.xCrossRefGoogle ScholarPubMed
Davey Smith, G, Hypponen, E, Power, C, Lawlor, DAOffspring birth weight and parental mortality: prospective observational study and meta-analysis. Am J Epidemiol. 2007; 166, 160–169.CrossRefGoogle ScholarPubMed
Manor, O, Koupil, IBirth weight of infants and mortality in their parents and grandparents: the Uppsala Birth Cohort Study. Int J Epidemiol. 2010; 39, 1264–1276.10.1093/ije/dyq046CrossRefGoogle ScholarPubMed
Shrivastava, A, Murrin, C, O’Brien, J, et al.Grandparental morbidity and mortality patterns are associated with infant birth weight in the Lifeways cross-generation cohort study 2001–2010. J Dev Orig Health Dis. 2012; 3, 458–468.CrossRefGoogle ScholarPubMed
McCarron, P, Davey Smith, G, Hattersley, ATType 2 diabetes in grandparents and birth weight in offspring and grandchildren in the ALSPAC study. J Epidemiol Community Health . 2004; 58, 517–522.CrossRefGoogle ScholarPubMed
Naess, O, Stoltenberg, C, Hoff, DA, et al.Cardiovascular mortality in relation to birth weight of children and grandchildren in 500,000 Norwegian families. Eur Heart J. 2013; 34, 3427–3436.CrossRefGoogle ScholarPubMed
Hales, CN, Barker, DJThe thrifty phenotype hypothesis. Br Med Bull. 2001; 60, 5–20.CrossRefGoogle ScholarPubMed
Kong, A, Thorleifsson, G, Frigge, ML, et al.The nature of nurture: effects of parental genotype. Science. 2018; 359, 424–428.CrossRefGoogle Scholar
Gasevic, D, Ross, ES, Lear, SAEthnic differences in cardiovascular disease risk factors: a systematic review of North American evidence. Can J Cardiol. 2015; 31, 1169–1179.CrossRefGoogle ScholarPubMed
Wandell, PE, Carlsson, A, Steiner, KHPrevalence of diabetes among immigrants in the Nordic countries. Curr Diabetes Rev. 2010; 6, 126–133.10.2174/157339910790909404CrossRefGoogle ScholarPubMed
Montesi, L, Caletti, MT, Marchesini, GDiabetes in migrants and ethnic minorities in a changing World. World J Diabetes . 2016; 7, 34–44.10.4239/wjd.v7.i3.34CrossRefGoogle Scholar
Sletner, L, Rasmussen, S, Jenum, AK, Nakstad, B, Jensen, OH, Vangen, SEthnic differences in fetal size and growth in a multi-ethnic population. Early Hum Dev. 2015; 91, 547–554.CrossRefGoogle Scholar
Jenum, AK, Sletner, L, Voldner, N, et al.The STORK Groruddalen research programme: a population-based cohort study of gestational diabetes, physical activity, and obesity in pregnancy in a multiethnic population. Rationale, methods, study population, and participation rates. Scand J Public Health. 2010; 38, 60–70.10.1177/1403494810378921CrossRefGoogle Scholar
Sletner, L, Jenum, AK, Morkrid, K, et al.Maternal life course socio-economic position and offspring body composition at birth in a multi-ethnic population. Paediatr Perinat Epidemiol. 2014; 28, 445–454.CrossRefGoogle Scholar
Sommer, C, Sletner, L, Jenum, AK, et al. Ethnic differences in maternal dietary patterns are largely explained by socio-economic score and integration score: a population-based study. Food Nutr Res. 2013; 57. doi: 10.3402/fnr.v57i0.21164.CrossRefGoogle Scholar
Morkrid, K, Jenum, AK, Berntsen, S, et al.Objectively recorded physical activity and the association with gestational diabetes. Scand J Med Sci Sports . 2014; 24, e389–e397.CrossRefGoogle ScholarPubMed
Jenum, AK, Morkrid, K, Sletner, L, et al.Impact of ethnicity on gestational diabetes identified with the WHO and the modified International Association of Diabetes and Pregnancy Study Groups criteria: a population-based cohort study. Eur J Endocrinol. 2012; 166, 317–324.10.1530/EJE-11-0866CrossRefGoogle ScholarPubMed
Uzan, J, Carbonnel, M, Piconne, O, Asmar, R, Ayoubi, JMPre-eclampsia: pathophysiology, diagnosis, and management. Vasc Health Risk Manag. 2011; 7, 467–474.Google ScholarPubMed
Smith, GC, Wood, AM, White, IR, Pell, JP, Hattie, JBirth weight and the risk of cardiovascular disease in the maternal grandparents. Am J Epidemiol. 2010; 171, 736–744.10.1093/aje/kwp448CrossRefGoogle ScholarPubMed
Beaumont, R, Horikosho, M, McCarthy, MI, Freathy, RMHow can genetic studies help us to understand links between birth weight and type 2 diabetes? Curr Diab Rep. 2017; 17, 22.CrossRefGoogle ScholarPubMed
Warrington, NM, Beaugmont, RN, Horikoshi, M, et al.Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors. Nat Genet. 2019; 51, 804–814.10.1038/s41588-019-0403-1CrossRefGoogle ScholarPubMed
Longmore, DK, Barr, ELM, Lee, I-L, et al.Maternal body mass index, excess gestational weight gain, and diabetes are positively associated with neonatal adiposity in the Pregnancy and Neonatal Diabetes Outcomes in Remote Australia (PANDORA) study. Pediatr Obes. 2019; 14, e12490. https://doi.org/10.1111/ijpo.12490CrossRefGoogle ScholarPubMed
Supplementary material: File

Kjøllesdal et al. supplementary material

Kjøllesdal et al. supplementary material

Download Kjøllesdal et al. supplementary material(File)
File 26.9 KB