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White-Matter Changes on MRI as Surrogate Marker

Published online by Cambridge University Press:  10 January 2005

Philip Scheltens ,
Frederik Barkhof  and
Franz Fazekas
Philip Scheltens
Affiliation:
Department of Neurology and the Alzheimer Centre, Vrije Universiteit Medical Centre, Amsterdam, The Netherlands
Frederik Barkhof
Affiliation:
Department of Radiology and the Image Analysis Centre, Vrije Universiteit Medical Centre, Amsterdam, The Netherlands
Franz Fazekas
Affiliation:
Department of Neurology, Karl-Franzens University, Graz, Austria
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Abstract

This article reviews the use of white-matter changes as identified on MRI as a surrogate marker in clinical trials on vascular dementia. As of yet, insufficient evidence is present to implement rating or volumetric assessment of the burden of white-matter changes as surrogate marker in such trials, in view of the limited sensitivity to change of current methods and the high measurement error.

Keywords

Dementiawhite matterMRIclinical trialsvascularpH
Type
TRIL DESIGNS: SLOW PROGRESSION
Information
International Psychogeriatrics , Volume 15 , Issue S1 , July 2003 , pp. 261 - 265
Copyright
© 2003 International Psychogeriatric Association

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