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Interleukin 1B gene (IL1B) variation and internalizing symptoms in maltreated preschoolers

Published online by Cambridge University Press:  25 November 2014

Kathryn K. Ridout ,
Stephanie H. Parade ,
Ronald Seifer ,
Lawrence H. Price ,
Joel Gelernter ,
Paloma Feliz  and
Audrey R. Tyrka
Kathryn K. Ridout
Affiliation:
Butler Hospital Mood Disorders Research Program and Laboratory for Clinical and Translational Neuroscience Alpert Medical School of Brown University
Stephanie H. Parade
Affiliation:
Alpert Medical School of Brown University E. P. Bradley Hospital Bradley/Hasbro Children's Research Center
Ronald Seifer
Affiliation:
Alpert Medical School of Brown University E. P. Bradley Hospital Bradley/Hasbro Children's Research Center
Lawrence H. Price
Affiliation:
Butler Hospital Mood Disorders Research Program and Laboratory for Clinical and Translational Neuroscience Alpert Medical School of Brown University
Joel Gelernter
Affiliation:
Yale University School of Medicine and VA CT Healthcare Center
Paloma Feliz
Affiliation:
E. P. Bradley Hospital Bradley/Hasbro Children's Research Center
Audrey R. Tyrka*
Affiliation:
Butler Hospital Mood Disorders Research Program and Laboratory for Clinical and Translational Neuroscience Alpert Medical School of Brown University
*
Address correspondence and reprint requests to: Audrey R. Tyrka, Butler Hospital, 345 Blackstone Boulevard, Providence, RI 02906; E-mail: audrey_tyrka@brown.edu.
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Abstract

Evidence now implicates inflammatory proteins in the neurobiology of internalizing disorders. Genetic factors may influence individual responses to maltreatment; however, little work has examined inflammatory genetic variants in adults and none in children. The present study examined the role of an interleukin 1B gene (IL1B) variant in preschoolers exposed to maltreatment and other forms of adversity in internalizing symptom development. One hundred ninety-eight families were enrolled, with one child (age 3–5 years) from each family. Adversity measures included child protective service documentation of moderate–severe maltreatment in the last 6 months and interview-assessed contextual stressors. Internalizing symptoms were measured using the Child Behavior Checklist and the Diagnostic Infant and Preschool Assessment. Maltreated children had higher major depressive disorder (MDD) and posttraumatic stress disorder symptoms and marginally higher internalizing symptoms on the Child Behavior Checklist. Controlling for age, sex, and race, IL1B genotype was associated with MDD symptoms (p = .002). Contextual stressors were significantly associated with MDD and posttraumatic stress disorder and marginally with internalizing symptoms. The IL1B genotype interacted with contextual stress such that children homozygous for the minor allele had more MDD symptoms (p = .045). These results suggest that genetic variants of IL1B may modulate the development of internalizing symptoms in the face of childhood adversity.

Type
Regular Articles
Information
Development and Psychopathology , Volume 26 , Special Issue 4pt2: Multilevel Developmental Perspectives Toward Understanding Internalizing Psychopathology: Current Research and Future Directions , November 2014 , pp. 1277 - 1287
Copyright
Copyright © Cambridge University Press 2014 

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