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The carcinogenic, mutagenic and teratogenic toxicity of bracken

Published online by Cambridge University Press:  05 December 2011

I. Antice Evans
Affiliation:
Department of Biochemistry and Soil Science, University College of North Wales, Bangor, Gwynedd
J. H. Prorok
Affiliation:
Department of Biochemistry and Soil Science, University College of North Wales, Bangor, Gwynedd
R. C. Cole
Affiliation:
Department of Biochemistry and Soil Science, University College of North Wales, Bangor, Gwynedd
M. H. Al-Salmani
Affiliation:
Department of Biochemistry and Soil Science, University College of North Wales, Bangor, Gwynedd
A. M. H. Al-Samarrai
Affiliation:
Department of Biochemistry and Soil Science, University College of North Wales, Bangor, Gwynedd
M. C. Patel
Affiliation:
Department of Biochemistry and Soil Science, University College of North Wales, Bangor, Gwynedd
R. M. M. Smith
Affiliation:
Department of Biochemistry and Soil Science, University College of North Wales, Bangor, Gwynedd
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Synopsis

Information concerning the carcinogenicity of bracken fern (Pteridium aquilinum) in different species and organs is reviewed. Various methods used in attempts to identify the plant components responsible are described and the results evaluated. Reference is made to recent and current research in this field (University College of North Wales, Bangor) and includes mutagenic and sterility studies, and the introduction of teratogenic screening by injection of Japanese quail eggs. The many problems still challenging bracken workers are indicated, and a final section deals with the potential hazard to human health in an attempt to link experimental work with epidemiological surveys of human cancer incidence. One important result of the study of bracken carcinogenicity is that active components, previously thought to be harmless, can be found in a wide variety of regular dietary items.

Type
Research Article
Copyright
Copyright © Royal Society of Edinburgh 1982

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References

Ambrose, A. M., Robbins, D. J. and DeEds, F. 1952. Comparative toxicities of quercetin and quercitrin. J. Am. Pharm. Ass. 41, 119122.Google Scholar
Ames, B. Y. 1971. The detection of chemical mutagens with enteric bacteria. In Chemical Mutagens, Principles and Methods for their Detection, ed. Hollaender, A. Vol. 1, pp. 267282. New York: Plenum Press.Google Scholar
Ames, B. N., McCann, J. and Yamasaki, E. 1975. Methods for detecting carcinogens and mutagens with the Salmonella mammalian microsome mutagenicity test. Mutation Res. 31, 347364.CrossRefGoogle ScholarPubMed
Barber, G. D. 1969. Mutagenic and other radiomimetic properties of bracken. Ph.D. Thesis, Univ. of Wales, Bangor.Google Scholar
Bateman, A. J. 1966. Testing chemicals for mutagenicity in a mammal. Nature, Lond. 210, 205206.CrossRefGoogle Scholar
Bjeldanes, L. F. and Chang, G. W. 1977. Mutagenic activity of quercetin and related compounds. Science NY. 197, 577578.CrossRefGoogle ScholarPubMed
Braid, K. W. 1959. Bracken: A review of the literature. Commonwealth Bureau of Pastures and Field Crops, Mimeographed Publication No. 3, 1959.Google Scholar
Bralow, S. P. 1972. Experimental Carcinogenesis. Digestion 5, 290310.CrossRefGoogle Scholar
Brown, J. P. and Dietrich, P. S. 1979. Mutagenicity of plant flavonols in the Salmonella mammalian microsome test. Activation of flavonol glycosides by mixed glycosidases from rat cecal bacteria and other sources. Mutation Res. 66, 223240.CrossRefGoogle ScholarPubMed
Epstein, S. S. and Shafner, H. 1968. Chemical mutagens in the human environment. Nature, Lond. 219, 385387.CrossRefGoogle ScholarPubMed
Evans, I. A. 1968. The radiomimetic nature of bracken toxin. Cancer Res. 28, 22522261.Google Scholar
Evans, I. A. 1972. Bracken fern toxin. In Oncology 1970: Proceedings of the Tenth International Cancer Congress. Vol. V, Part A “Environmental Cancer”, pp. 178195. Chicago, Illinois: Year Book Medical Publishers.Google Scholar
Evans, I. A. 1976. Relationship between bracken and cancer. Bot. J. Linn. Soc. 73, nos. 1–3, 105–112.CrossRefGoogle Scholar
Evans, I. A. 1979. Bracken carcinogenicity. Res. Vet. Sci. 26, 339348.Google Scholar
Evans, I. A., Barber, G. D., Jones, R. S. and Leach, H. 1969. The carcinogenic activity of bracken. Rep. Br. Emp. Cancer Campn pp. 446—447.Google Scholar
Evans, I. A., Jones, R. S. and Mainwaring-Burton, R. 1972. Passage of bracken fern toxicity into milk. Nature, Lond. 237, 107108.CrossRefGoogle ScholarPubMed
Evans, I. A. and Mason, J. 1965. Carcinogenic activity of bracken. Nature, Lond. 208, 913914.Google Scholar
Evans, I. A. and Osman, M. A. 1974. Carcinogenicity of bracken and shikimic acid. Nature, Lond. 250, No. 5464, 348349.CrossRefGoogle ScholarPubMed
Evans, I. A. and Widdop, B. 1966. Carcinogenic activity of bracken. Rep. Br. Emp. Cancer Campn p. 377.Google Scholar
Evans, I. A., Widdop, B. and Barber, G. D. 1967. Carcinogenic activity of bracken. Rep. Br. Emp. Cancer Campn p. 411.Google Scholar
Grimshaw, W. T. R. and Evans, I. A. 1980. The inter-relationship between bovine neoplasia and bracken fern (Pteridium aquilinum). In Oncology Supplement: Scientific Foundations of Oncology, ed. Symington, T. and Carter, R. L. pp. 4960. London: William Heinemann Medical Books.Google Scholar
Hall, L. D. 1964. The conformations of cyclic compounds in solution. I. Shikimic Acid. J. Org. Chem. 29, 297299.CrossRefGoogle Scholar
Hasegawa, M. and Tateoka, T. 1960. Occurrence of shikimic acid in plant tissue, III. Seasonal variation of shikimic acid content. J. Jap. For. Soc. 42, 224225.Google Scholar
Herrmann, K. 1976. Flavonols and flavones in food plants: a review. J. Fd Technol. 11, 433448.CrossRefGoogle Scholar
Hirono, I. 1979. Naturally-occurring carcinogenic substances. Gann Monogr. Cancer Res. 24, 85102.Google Scholar
Hirono, I., Fushimi, K. and Matsubara, N. 1977. Carcinogenicity test of shikimic acid in rats. Toxic. Lett. 1, 910.Google Scholar
Hirono, I. Fushimi, K., Mori, H., Miwa, T. and Haga, M. 1973. Comparative study of carcinogenic activity in each part of bracken. J. Natn Cancer Inst. 50, 13671371.CrossRefGoogle ScholarPubMed
Hirono, I., Sasaoka, I., Shibuya, C., Shimizu, M., Fushimi, K., Mori, H., Kato, K. and Haga, M. 1975. Natural carcinogenic products of plant origin. Gann Monogr. Cancer Res. 17, 205217.Google Scholar
Hirono, I., Shibuya, C., Fushimi, K. and Haga, M. 1970. Studies on carcinogenic properties of bracken, Pteridium aquilinum. J. Natn Cancer Inst. 45, 179188.Google ScholarPubMed
Hirono, I., Shibuya, C., Shimizu, M. and Fushimi, K. 1972. Carcinogenic activity of processed bracken used as human food. J. Natn Cancer Inst. 48, 12451250.Google Scholar
Hirono, I., Ushimaru, Y., Kato, K., Mori, H. and Sasaoka, I. 1978. Carcinogenicity of boiling water extract of bracken, Pteridium aquilinum. Gann 69, 383388.Google Scholar
Hodge, W. H. 1973. Fern foods of Japan and the problem of toxicity. Am. Fern J. 63, no. 3, 7780.CrossRefGoogle Scholar
Ishii, K., Saito, T. and Sakatami, M. 1974. Histamine releasing action of acetone dried powder of bracken fern on the rat peritoneal mast cells. J. Fac. Agric. Tortori Univ. 9, 2733.Google Scholar
Jarrett, W. F. H. 1981. Bracken and cancer. Proc. Roy. Soc. Edinb. 81B, 7983.Google Scholar
Jones, R. S. 1974. Bracken Carcinogenesis. Ph.D. Thesis, Univ. of Wales, Bangor.Google Scholar
Kamon, S. and Hirayama, T. 1975. Epidemiology of cancer of the oesophagus in Miye, Nara and Wakayama Prefecture with special reference to the role of bracken fern. Proc. Jap. Cancer Ass. 34th Annual Meeting (Osaka), p. 211.Google Scholar
Kuhnau, J. 1976. The Flavonoids. A class of semi-essential food components: their role in human nutrition. Wld Rev. Nutr. Diet. 24, 117191.Google Scholar
Kuroyanagi, M., Fukuoka, M., Yoshihira, K. and Natori, S. 1974. Absolute configuration of pterosins, 1-indanone derivatives from bracken “Pteridium aquilinum var. latiusculum”. Chem. Pharm. Bull. Tokyo 22(3), 723726.CrossRefGoogle Scholar
Lauren, P. 1965. The two histological main types of gastric carcinoma: diffuse and so-called intestinal-type carcinoma. Acta Path. Microbiol. Scand. 64, 3149.CrossRefGoogle ScholarPubMed
Leach, H. 1970. The chemical isolation of a toxic component of bracken. M.Sc. Thesis, Univ. of Wales, Bangor.Google Scholar
Leach, H., Barber, G. D., Evans, I. A. and Evans, W. C. 1971. Isolation of an active principle from the bracken fern that is mutagenic, carcinogenic and lethal to mice on intraperitoneal injection. Biochem. J. 124, 1314.CrossRefGoogle ScholarPubMed
Morris, H. P., Wagner, B. P., Ray, F. E., Stewart, H. L. and Snell, K. C. 1962. Comparative carcinogenic effects of N,N′-2,7-fluorenylenebisacetamide by intraperitoneal and oral routes of administration to rats with particular reference to gastric carcinoma. J. Natn Cancer Inst. 29, 9771011.Google Scholar
Munoz, M. and Connelly, R. 1971. Time trends of intestinal and diffuse types of gastric cancer in the United States. Int. J. Cancer 8, 158164.Google Scholar
Munoz, N., Correa, P., Cuello, C. and Duque, E. 1968. Histological types of gastric carcinoma in high and low risk areas. Int. J. Cancer 3, 809818.CrossRefGoogle ScholarPubMed
Nakabayashi, T. 1955. Isolation of Astragalin and Isoquercitrin from bracken, Pteridium aquilinum. Bull. Agric. Chem. Soc. Japan 19, no. 2, 104109.CrossRefGoogle Scholar
Newberne, P. M. 1976. Biological effects of plant toxins and aflatoxins in rats. J. Natn Cancer Inst. 56, no. 3, 551555.Google Scholar
Osman, M. A. 1974. The isolation and chemistry of bracken toxins. Ph.D. Thesis, Univ. of Wales, Bangor.Google Scholar
Pamukcu, A. M. and Bryan, G. T. 1979. Bracken fern, a natural urinary bladder and intestinal carcinogen.In Naturally Occurring Carcinogens-Mutagens and Modulators of Carcinogenesis, ed. Miller, E. C., Miller, J. A., Hirono, I., Sigimura, T. and Takayama, S., pp. 8999. Baltimore: University Park Press.Google Scholar
Pamukcu, A. M., Erturk, E. and Bryan, G. T. 1977. Induction of urinary bladder and intestinal tumours in mice by feeding bracken fern. Ankara Univ. Vet. Fak. Derg. 24, 2834.Google Scholar
Pamukcu, A. M., Erturk, E., Price, J. M. and Bryan, G. T. 1972. Lymphatic leukemia and pulmonary tumours in female Swiss mice fed bracken fern (Pteris aquilinum). Cancer Res. 32, 14421445.Google Scholar
Pamukcu, A. M., Erturk, E., Yalciner, S., Milli, U. and Bryan, G. T. 1978. Carcinogenic and mutagenic activities of milk from cows fed bracken fern (Pteridium aquilinum). Cancer Res. 38, 15561560.Google Scholar
Pamukcu, A. M. and Price, J. M. 1969. Induction of urinary bladder cancer in rats by feeding bracken fern (Pteris aquilina). J. Natn Cancer Inst. 43, 275281.Google Scholar
Pamukcu, A. M., Price, J. M. and Bryan, G. T. 1976. Naturally occurring and bracken-fern-induced bovine urinary bladder tumours. Vet. Pathol. 13, 110122.CrossRefGoogle Scholar
Pamukcu, A. M., Yalciner, S., Price, J. M. and Bryan, G. T. 1970a. Effects of the co-administration of thiamine on the incidence of urinary bladder carcinomas in rats fed bracken fern. Cancer Res. 30, 26712674.Google Scholar
Pamukcu, A. M., Price, J. M. and Bryan, G. T. 1970b. Assay of fractions of bracken fern (Pteris aquilina) for carcinogenic activity. Cancer Res. 30, 902905.Google Scholar
Pamukcu, A. M., Wattenberg, L. W., Price, J. M. and Bryan, G. T. 1971a. Phenothiazine inhibition of intestinal and urinary bladder tumours induced in rats by bracken fern. J. Natn Cancer Inst. 47, 155159.Google ScholarPubMed
Pamukcu, A. M., Price, J. M. and Bryan, G. T. 1971b. Altered urinary and intestinal carcinogenic activity of bracken fern in rats. Proc. Am. Ass. Cancer Res. 12, 7.Google Scholar
Pamukcu, A. M., Yalciner, S., Hatcher, J. F. and Bryan, G. T. 1980a. Quercetin a rat intestinal and bladder carcinogen present in bracken fern (Pteridium aquilinum). Cancer Res. 40, 34683472.Google Scholar
Pamukcu, A. M., Wang, C. T., Hatcher, J. and Bryan, G. T. 1980b. Oncogenicity of tannin from bracken ferns. J. Natn Cancer Inst. 65, no. 1, 131136.Google Scholar
Parry, J. M. and Tippins, R. 1976. Personal communication.Google Scholar
Partington, M. and Bateman, A. J. 1964. Dominant lethal mutations induced in male mice by methyl methanesulphonate. Heredity, Lond. 19, 191200.Google Scholar
Price, J. M. and Pamukcu, A. M. 1968. The induction of neoplasms of the urinary bladder of the cow and the small intestine of the rat by feeding bracken fern (Pteris aquilina). Cancer Res. 28, 22472251.Google Scholar
Prorok, J. H. 1978. Bracken derived morphogenic dyscrasias. Ph.D. Thesis, Univ. of Wales, Bangor.Google Scholar
Roberts, I. M., Shaw, D. S. and Evans, W. C. 1971. A T4 bacteriophage reversion test for the naturally occurring mutagen present in bracken fern (Pteridium aquilinum). Biochem. J. 124, 13.Google Scholar
Salmani, Al-, Adaay, M. H. 1980. Studies on plant derived teratogenicity and infertility. Ph.D. Thesis, Univ. of Wales, Bangor.Google Scholar
Segi, M. 1975. Tea-gruel as a possible factor for cancer of the oesophagus. Gann 66, 199202.Google Scholar
Stewart, H. L. 1953. Experimental cancer of the alimentary tract. The physiopathology of cancer, pp. 345. New York: Harper & Row.Google Scholar
Sugimura, T. 1979. Naturally occurring genotoxic carcinogens. In Naturally Occurring Carcinogens—Mutagens and Modulators of Carcinogenesis, ed. Miller, E. C., Miller, J. A., Hirono, I., Sugimura, T. and Takayama, S., pp. 241261. Baltimore: University Park Press.Google Scholar
Sugimura, T., Fujimura, S., Kogure, K., Baba, T., Saito, T., Nagao, M., Hosoi, H., Shimosato, Y. and Yokoshima, T. 1969. Production of adenocarcinomas in glandular stomach of experimental animals by N-methyl-N′-nitro-N-nitrosoguanidine. Gann Monogr. 8, 157208.Google Scholar
Sugimura, T., Nagao, M., Matsushima, T., Yahagi, T., Seino, Y., Shirai, A., Sawamura, M., Natori, S., Yoshirhira, K., Fukuoka, M. and Kuroyanagi, M. 1977. Mutagenicity of flavone derivatives. Proc. Japan Acad. 53B, 194197.Google Scholar
Sugimura, T., Sato, S., Naga, C M., Yahagi, T., Matsushima, T., Seino, Y., Takeuchi, M. and Kawachi, T. 1976. Overlapping of carcinomas and mutagens. Fundam. Cancer Prev., 6th Symp. Princess Takamatsu Cancer Res. Fund (1975), ed. Magee, P. N., pp. 191215. University of Tokyo Press.Google Scholar
Takatori, K., Nakano, S., Magata, S., Okumura, K., Hirono, I. and Shimizu, M. 1972. Pterolactam, a new compound isolated from bracken. Chem. Pharm. Bull. Tokyo 20(5), 1087.Google Scholar
Wang, C. Y., Pamukcu, A. M. and Bryan, G. T. 1973. Detection of carcinogenic activity in different extracts of bracken fern. Proc. Am. Ass. Cancer Res. 14, 12.Google Scholar
Wang, C. Y., Pamukcu, A. M. and Bryan, G. T. 1976a. Bracken fern as a naturally occurring carcinogen. In “Ecological Perspectives on Carcinogens and Cancer Control”, ed. Stock, C. C., Santamaria, L., Mariani, P. and Gorini, S. Med. Biol. Environ. 4, 565–572.Google Scholar
Wang, C. H., Chiu, C. W., Pamukcu, A. M. and Bryan, G. T. 1976b. Identification of carcinogenic tannin isolated from bracken fern (Pteridium aquilinum). J. Natn Cancer Inst. 56, 3336.CrossRefGoogle ScholarPubMed
Widdop, B. 1967. Separation and characterisation of various toxicological components of bracken. Ph.D. Thesis, Univ. of Wales, Bangor.Google Scholar
Wislocki, P. G., Miller, E. C., Miller, J. A., McCoy, E. C. and Rosenkran, H. S. 1977. Carcinogenic and mutagenic activities of safrole, 1′-hydroxysafrole, and some known or possible metabolites. Cancer Res. 37, 18831891.Google ScholarPubMed
Wogan, G. M., Busby, W. F. Jr., 1980. Naturally occurring carcinogens. In Toxic Constituents of Plant Foodstuffs (2nd edn), pp. 329369. New York: Academic Press.Google Scholar
Won, O. H., Farman, J., Krishnan, M. H., Iyer, S. K. and Vuletin, C. 1978. Squamous cell carcinoma of the stomach. Am. J. Gastroent. 69, 594598.Google ScholarPubMed
Yoshihira, K., Fukuoka, M., Kuroyanagi, M. and Natori, S. 1971. 1-Indanone derivatives from bracken, Pteridium aquilinam var. latinusculum. Chem. Pharm. Bull. Tokyo 19(7), 14911495.Google Scholar
Yoshihira, K., Fukuoka, M., Kuroyanagi, M., Natori, S., Umeda, M., Morohishi, T., Enomoto, M. and Saito, M. 1978. Chemical and toxicological studies on bracken fern (Pteridium aquilinum var. latiusculum. I. Introduction, extraction and fractionation of constituents to, and toxicological studies including carcinogenicity tests. Chem. Pharm. Bull. Tokyo 26(8), 23462364.Google Scholar