Asmussen, E. (1967). Exercise and the regulation of ventilation. In Physiology of Muscular Exercise (ed. Chapman, C. B.), pp. 132–45. Circulation Res. XX, XXI, Suppl. 1.Google Scholar

Asmussen, E. & Chiodi, H. (1941). The effect of hypoxemia on ventilation and circulation in man. Am. J. Physiol. 132, 426–36.CrossRefGoogle Scholar

Asmussen, E. & Nielsen, M. (1946). Studies on the regulation of respiration in heavy work. Acta phyiol. scand. 12, 171–88.CrossRefGoogle Scholar

Asmussen, E. & Nielsen, M. (1957). Ventilatory response to CO₂ during work at normal and at low oxygen tensions. Acta physiol. scand. 39, 27–35.CrossRefGoogle ScholarPubMed

Asmussen, E. & Nielsen, M. (1958). Pulmonary ventilation and effect of oxygen breathing in heavy exercise. Acta physiol. scand. 43, 365–78.Google Scholar

Bainton, C. R. & Mitchell, R. A. (1966). Posthyperventilation apnea in awake man. J. appl. Phys. 21, 411–15.Google ScholarPubMed

Band, D. M., Cameron, I. R. & Semple, S. J. G. (1969). Effect of different methods of CO₂ administration on oscillations of arterial pH in the cat. J. appl. Phys. 26, 268–73.Google ScholarPubMed

Band, D. M., Cameron, I. R. & Semple, S. J. G. (1970). The effect on respiration of abrupt changes in carotid artery pH and P_co2 in the cat. J. Physiol., Lond. 211, 479–94.CrossRefGoogle ScholarPubMed

Band, D. M., Saunders, K. B. & Wolff, C. B. (1971). The relation between chemoreceptor discharge and respiratory fluctuation of arterial pH in the anaesthetised cat. J. Physiol., Lond. 218, 73P.Google Scholar

Band, D. M. & Wolff, C. B. (1973). The effect of hypoxia on the respiratory fluctuations in chemoreceptor discharge in the cat. J. Physiol., Lond. 234, 71P.Google ScholarPubMed

Bannister, R. G. & Cunningham, D. J. C. (1954). The effects on the respiration and performance during exercise of adding oxygen to the inspired air. J. Physiol. 125, 118–37.Google Scholar

Baxter, I. G. & Pearce, J. W. (1951). Simultaneous measurement of pulmonary arterial flow and pressure using condenser manometers. J. Physiol. 115, 410–29.CrossRefGoogle ScholarPubMed

Bhattacharyya, N. K., Cunningham, D. J. C., Goode, R. C., Howson, M. G. & Lloyd, B. B. (1970). Hypoxia, ventilation, P_co2 and exercise. Resp. Physiol. 9, 329–47.CrossRefGoogle ScholarPubMed

Biscoe, T. J. (1971). Carotid body: structure and function. Physiol. Rev. 51, 427–95.CrossRefGoogle ScholarPubMed

Biscoe, T. J., Lall, A. & Sampson, S. R. (1970). Electron microscopic and electrophysiological studies on the carotid body following intracranial section of the glossopharyngeal nerve. J. Physiol., Lond. 208, 133–52.CrossRefGoogle ScholarPubMed

Biscoe, T. J. & Purves, M. J. (1965). Carotid chemoreceptor and cervical sympathetic activity during passive hind limb exercise in the anaesthetized cat. J. Physiol., Lond. 178, 43–44P.Google Scholar

Biscoe, T. J. & Purves, M. J. (1967). Observations on the rhythmic variation in the cat carotid body chemoreceptor activity which has the same period as respiration. J. Physiol., Lond. 190, 389–42.Google Scholar

Biscoe, T. J., Purves, M. J. & Sampson, S. R. (1970). The frequency of nerve impulses in single carotid body chemoreceptor afferent fibres recorded in vivo with intact circulation. J. Physiol, Lond. 208, 121–31.CrossRefGoogle ScholarPubMed

Black, A. M. S., Goodman, M. W., Nail, B. S., Rao, P. S. & Torrance, R. W. (1973). The significance of the timing of chemoreceptor impulses for their effect upon respiration. Acta neurobiol. exper. 33, 139–47.Google ScholarPubMed

Black, A. M. S., McCloskey, D. I. & Torrance, R. W. (1971). The responses of carotid body chemoreceptors in the cat to sudden changes of hypercapnic and hypoxic stimuli. Resp. Physiol. 13, 36–49.CrossRefGoogle ScholarPubMed

Black, A. M. S. & Torrance, R. W. (1967). Chemoreceptor effects in the respiratory cycle. J. Physiol. 189, 59–61P.Google ScholarPubMed

Black, A. M. S. & Torrance, R. W. (1971). Respiratory oscillations in chemoreceptor discharge in the control of breathing. Resp. Physiol. 13, 221–37.Google Scholar

Boushey, H. A. & Richardson, P. S. (1973). The reflex effects of intra-laryngeal carbon dioxide on the pattern of breathing. J. Physiol., Lond. 228, 181–92.CrossRefGoogle Scholar

Bouverot, P., Flandrois, R., Puccinelli, R. & Dejours, P. (1965). Étude du rôle des chémorécepteurs artériels dans la regulation de la respiration pulmonaire chez le chien éveillé. Archs mt. Pharmacodyn. Ther. 157, 253–71.Google Scholar

Chalazonitis, N. (1968). Intracellular P₀₂ control on excitability and synaptic activability in Aplysia and Helix identifiable giant neurones. Ann. N.Y. Acad. Sci. 147, 419–59.Google Scholar

Chapman, C. B. (ed.) (1967). Physiology of Muscular Exercise. Circulation Res. xx, xxi, Suppl. 1.Google Scholar

Cherniack, N. S., Edelman, N. H. & Lahiri, S. (1971). Hypoxia and hypercapnia as respiratory stimulants and depressants. Resp. Physiol. II, 113–26.Google Scholar

Clark, F. J. & Von Euler, C. (1972). On the regulation of depth and rate of breathing. J. Physiol., Lond. 222, 267–95.CrossRefGoogle ScholarPubMed

Cohen, P. J., Alexander, S. C., Smith, T. C., Reivich, M. & Wollman, H. (1967). Effect of hypoxia and normocarbia on cerebral blood flow and metabolism in conscious man. J. Appl. Physiol. 23, 183–9.Google Scholar

Comroe, J. H. & Schmidt, C. F. (1938). The part played by reflexes from the carotid body in the chemical regulation of respiration in the dog. Am. J. Physiol. 121, 75–97.Google Scholar

Cormack, R. S., Cunningham, D. J. C. & Gee, J. B. L. (1956). The effects of hypercapnia and acapnia on the respiratory response to acute want of oxygen in man. J. Physiol., Lond. 133, 47–48P.Google Scholar

Cormack, R. S., Cunningham, D. J. C. & Gee, J. B. L. (1957). The effect of carbon dioxide on the respiratory response to want of oxygen in man. Q. Jl exp. Physiol. 42, 303–19.CrossRefGoogle ScholarPubMed

Crosfill, M. L. & Widdicombe, J. G. (1961). Physical characteristics of the chest and lungs and the work of breathing in different mammalian species. J. Physiol., Lond. 158, 1–14.Google Scholar

Cunningham, D. J. C. (1963). Some quantitative aspects of the regulation of human respiration in exercise. Br. med. Bull. 19, 25–30.CrossRefGoogle ScholarPubMed

Cunningham, D. J. C. (1974). Integrative aspects of the regulation of breathing: a personal view. In International Review of Science, Section, I, Physiology (ed. Guyton, A. C.); Vol. II, Respiration (ed. Widdicombe, J. G.), pp. 303–68. Lancaster: Medical and Technical Publishing.Google Scholar

Cunningham, D. J. C., Elliott, D. H., Lloyd, B. B., Millier, J. P. & Young, J. M. (1965 b). A comparison of the effects of oscillating and steady alveolar partial pressures of oxygen and carbon dioxide on the pulmonary ventilation. J. Physiol. Lond. 179, 498–508.CrossRefGoogle ScholarPubMed

Cunningham, D. J. C., Goode, R. C. & Lloyd, B. B. (1967). Depression of ventilation after carbon monoxide. J. Physiol., Lond. 191, 44–45P.Google Scholar

Cunningham, D. J. C., Hey, E. N. & Lloyd, B. B. (1958). The effect of intravenous infusion of noradrenline on the respiratory response to carbon dixoide in man. Q. Jl exp. Physiol. 43, 394–9.CrossRefGoogle Scholar

Cunningham, D. J. C., Hey, E. N., Patrick, J. M. & Lloyd, B. B. (1963). The effect of noradrenaline infusion on the relation between pulmonary ventilation and alveolar P _o2 and P _co2 in man. Ann. N. Y. Acad. Sci. 109, 756–70.CrossRefGoogle ScholarPubMed

Cunningham, D. J. C., Howson, M. G. & Pearson, S. B. (1973). The respiratory effects in man of altering the time profile of alveolar CO₂ and O₂ within each respiratory cycle. J. Physiol., Lond. 234, 1–28.CrossRefGoogle Scholar

Cunningham, D. J. C., Lloyd, B. B., Miller, J. P. & Young, J. M. (1965). The time course of human ventilation after transient changes in P_A, CO₂, at two values of P_A, O₂. J. Physiol., Lond. 179, 68–70P.Google Scholar

Cunningham, D. J. C., Lloyd, B. B. & Spurr, D. (1966 a). The relationship between the increase in breathing during the first respiratory cycle in exercise and the prevailing background of chemical stimulation. J. Physiol., Lond. 185, 73–75P.Google Scholar

Cunningham, D. J. C., Lloyd, B. B. & Spurr, D. (1966 b). Doubts about the ‘anaerobic work… substance’ as a stimulus to breathing in exercise. J. Physiol., Lond. 186, 110–11 P.Google Scholar

Cunningham, D. J. C., & O'Riordan, L. H. (1957). The effect of a rise in the temperature of the body on the respiratory response to carbon dioxide at rest. Q. Jl exp. Physiol. 42, 329–45.Google Scholar

Cunningham, D. J. C., Patrick, J. M. & Lloyd, B. B. (1964). The respiratory response of man to hypoxia. In Oxygen in the Animal Organism (ed. Dickens, F. and Neil, E.), pp. 277–91. Oxford: Pergamon Press.CrossRefGoogle Scholar

Cunningham, D. J. C., Pearson, S. B. & Gardner, W. N. (1973). Regulation of respiratory frequency and tidal volume at various ventilations. Archo Fisiol. 69, Suppl., 433–46.Google Scholar

Cunningham, D. J. C., Spurr, D. & Lloyd, B. B. (1968). Ventilatory drive in hypoxic exercise. In Arterial Chemoreceptors (ed. Torrance, R. W.), pp. 301–23. Oxford: Blackwell.Google Scholar

Davies, R. O. & Lahiri, S. (1973). Absence of carotid chemoreceptor response during hypoxic exercise in the cat. Resp. Physiol. 18, 92–100.CrossRefGoogle ScholarPubMed

Defares, J. G. (1964). Principles of feedback control and their application to the respiratory control system. In Handbook of Physiology, section 3, Respiration, vol. I (ed. Fenn, W. O. and Rahn, H.), pp. 649–80. Washington, D.C.: American Physiological Society.Google Scholar

Dejours, P. (1959). La régulation de la ventilation au cours de l'exercice musculaire chez l'homme. J. Physiol., Paris 51, 163–261.Google Scholar

Dejours, P. (1964). Control of respiration in muscular exercise. Handbook of Physiology, section 3, Respiration, vol. I (ed. Fenn, W. O. and Rahn, H.), pp. 631–48. Washington, D.C.: American Physiological Society.Google Scholar

Dejours, P., Labrousse, Y., Raynaud, J., Girard, F. & Teillac, A. (1958). Stimulus oxygène de la ventilation au repos et au cours de l'exercice musculaire, à basse altitude (50 m), chez l'homme. Revue fr. Étud. clin. biol. 3, 105–23.Google Scholar

Dejours, P., Lefrançois, R., Flandrois, R. & Teillac, A. (1960). Autonomie des stimulus ventilatoires oxygène gaz carbonique et neurogénique de l'exercice musculaire. J. Physiol., Paris 52, 63–4.Google Scholar

Douglas, C. G. & Haldane, J. S. (1909 a). The regulation of normal breathing J. Physiol., Lond. 38, 420–40.CrossRefGoogle ScholarPubMed

Douglas, C. G. & Haldane, J. S. (1909 b). The causes of periodic or Cheyne–Stokes breathing. J. Physiol., Lond. 38, 401–19.Google Scholar

Douglas, C. G., Haldane, J. S., Henderson, Y. & Schneider, E. C. (1913). Physiological observations made on Pike's Peak, Colorado, with special reference to adaptation to low barometic pressures. Phil. Trans. R. Soc. Lond. B 203, 185–318.Google Scholar

DuBois, A. B., Britt, A. G. & Fenn, W. O. (1952). Alveolar CO₂ during the respiratory cycle. J. appl. Physiol. 4, 535–48.Google Scholar

DuBois, R. M. & Yamamoto, W. S. (1969). Modification of ventilatory response of cross-perfused rat by stirring the blood stream. Fedn Proc. Fedn Am. Socs exp. Biol. 28, 338.Google Scholar

Duffin, J. (1972). A mathematical model of the chemorefiex control of ventilation. Resp. Physiol. 15, 277–301.CrossRefGoogle ScholarPubMed

Dutton, R. E., Fitzgerald, R. S. & Gross, N. (1968). Ventilatory response to square-wave forcing of carbon dioxide at the carotid bodies. Resp. Physiol. 4, 101–8.Google Scholar

Dutton, R. E., Ghatak, P. K. & Davies, D. G. (1969). Regulation of respiration during ramp forcing of the carotid chemoreceptors with hypoxic blood. Fedn Proc. Fedn Am. Socs exp. Biol. 28, 338.Google Scholar

Dutton, R. E. & Permutt, S. (1968). Ventilatory responses to transient changes in carbon dioxide. In Arterial Chemoreceptors (ed. Torrance, R. W.), pp. 373–86. Oxford: Blackwell.Google Scholar

Edelman, N. H., Epstein, P., Lahiri, S. & Cherniack, N. S. (1973). Ventilatory responses to transient hypoxia and hypercapnia in man. Resp. Physiol. 17, 302–14.CrossRefGoogle ScholarPubMed

Von Euler, C. (1973). Time-dependent changes in responsiveness to inflations and deflations of the lungs during inspiration and expiration: their significance for the control of depth and rate of breathing. Archo Fisiol. 69, suppl., 424–32.Google Scholar

Euler, C. Von & Söderberg, U. (1952). Slow potentials in the respiratory centres. J. Physiol., Lond. 118, 555–64.CrossRefGoogle Scholar

Euler, U. S. Von, Liljestrand, G. & Zotterman, Y. (1939). The excitation mechanism of the chemoreceptors of the carotid body. Skand. Arch. Physiol. 83, 132–52.Google Scholar

Eyzaguirre, C. & Lewin, J. (1961). Chemoreceptor activity of the carotid body of the cat. J. Physiol. 159, 222–37.Google Scholar

Fenner, A. & Berndt, J. (1970). Ventilatory response to oscillating and non-oscillating P_A, CO₂ in the anaesthetized cat. Pflügers Arch. ges. Physiol. 318, 108–16.CrossRefGoogle Scholar

Filley, G. F., Beckwitt, H. J., Reeves, J. T. & Mitchell, R. S. (1968). Chronic obstructive broncho-pulmonary disease. II. Oxygen transport in two clinical types. Am. J. Med. 44, 26–38.Google Scholar

Fink, B. R., Hanks, E. C., Ngai, S. H. & Papper, E. M. (1963). Central regulation of respiration during anesthesia and wakefulness. Ann. N. Y. Acad. Sci. 109, 892–9.Google Scholar

Fitzgerald, M. P. (1914). Further observations on the changes in the breathing and the blood at various high altitudes. Proc. Roy. Soc. Lond. B 88, 248–58.Google Scholar

Fitzgerald, R. S. & Parks, D. C. (1971). Effect of hypoxia on carotid chemoreceptor response to carbon dioxide in cats. Resp. Physiol. 12, 218–29.Google Scholar

Fitzgerald, R. S., Gross, N. & Dutton, R. E. (1968). Ventilatory responses to transient acidic and hypercapnic vertebral artery infusions. Resp. Physiol. 4, 387–95.Google Scholar

Floyd, W. F. & Neil, E. (1952). The influence of the sympathetic innervation of the carotid bifurcation on chemoreceptor and baroreceptor activity in the cat. Archs int. Pharmacodyn. Ther. 91, 230–9.Google Scholar

Gabel, R. A., Kronenberg, R. S. & Severinghaus, J. W. (1973). Vital capacity breaths of 5% or 15% CO₂ in N₂ or O₂ to test carotid chemosensitivity. Resp. Physiol. 17, 195–208.CrossRefGoogle ScholarPubMed

Gesell, R., Lapides, J. & Levin, M. (1940). The interaction of central and peripheral chemical control of breathing. Am. J. Physiol. 130, 155–70.CrossRefGoogle Scholar

Goode, R. C. (1968). Some factors affecting respiration in man. D.Phil. Thesis, Oxford University.Google Scholar

Goode, R. C., Brown, E. B. Jr, Howson, M. G. & Cunningham, D. J. C. (1969). Respiratory effects of breathing down a tube. Resp. Physiol. 6, 343–59.Google Scholar

Goodman, N. (1972). Efferent control of arterial chemoreceptors. J. Physiol., Lond. 225, 31–2 P.Google Scholar

Gray, J. S. (1946). The multiple factor theory of the control of respiratory ventilation. Science, N.Y. 103, 739–44.CrossRefGoogle ScholarPubMed

Grodins, F. S. (1950). Analysis of factors concerned in regulation of breathing in exercise. Physiol. Rev. 30, 220–39.Google Scholar

Grodins, F. S., Buell, J. & Bart, A. J. (1967). Mathematical analysis and digital simulation of the respiratory control system. J. appl. Physiol. 22, 260–76.Google Scholar

Guz, A., Noble, M. I. M., Widdicombe, J. G., Trenchard, D. & Mushin, W. W. (1966). The effect of bilateral block of vagus and glossopharyngeal nerves on the ventilatory response to CO₂ of conscious man. Resp. Physiol. I, 206–10.Google Scholar

Haldane, J. S., Meakins, J. C. & Priestley, J. G. (1919). The respiratory response to anoxaemia. J. Physiol., Lond. 52, 420–32.Google Scholar

Haldane, J. S. & Priestley, J. G. (1905). The regulation of the lungventilation. J. Physiol., Lond. 32, 225–66.CrossRefGoogle ScholarPubMed

Hey, E. N., Lloyd, B. B., Cunningham, D. J. C., Jukes, M. G. M. & Bolton, D. P. G. (1966). Effects of various respiratory stimuli on the depth and frequency of breathing in man. Resp. Physiol. I, 193–205.Google Scholar

Hilton, S. M. & Joels, N. (1964). Facilitation of chemoreceptor reflexes during the defence reaction. J. Physiol., Lond. 176, 20–2 P.Google Scholar

Honda, Y., Natsui, T., Hasumura, N. & Nakamura, K. (1963). Threshold PCO₂ for respiratory system in acute hypoxia of dogs. J. appl. Physiol. 18, 1053–6.Google Scholar

Hornbein, T. F., Griffo, Z. J. & Roos, A. (1961). Quantitation of chemoreceptor activity: interrelation of hypoxia and hypercapnia. J. Neuro. physiol. 24, 561–8.Google ScholarPubMed

Hornbein, T. F., Roos, A. & Griffo, Z. J. (1961). Transient effect of sudden mild hypoxia on respiration. J. appl. Physiol. 26, 11–14.CrossRefGoogle Scholar

Horsfield, K., Cumming, G. & Hicken, P. (1966). A morphologic study of airway disease using bronchial casts. Am. Rev. resp. Dis. 93, 900–6.Google Scholar

Joels, N. & White, H. (1968). The contribution of the arterial chemoreceptors to the stimulation of respiration by adrenaline and nor-adrenaline in the cat. J. Physiol., Lond. 197, 1–24.Google Scholar

Kao, F. F. (1963). An experimental study of the pathways involved in exercise hyperpnoea employing cross-circulation techniques. In The Regulation of Human Respiration (ed. Cunningham, D. J. C. and Lloyd, B. B.), pp. 461–502. Oxford: Blackwell.Google Scholar

Kao, F. F., Lahiri, S., Wang, C. & Mel, S. S. (1967). Ventilation and cardiac output in exercise. Physiology of Muscular Exercise (ed. Chapman, C. B.), pp. 179–91. Circulation Res. xx, xxi, Suppl. I.Google Scholar

Kellogg, R. H. (1968). Altitude acclimatization, a historical introduction emphasizing the regulation of breathing. Physiologist II, 37–57.Google Scholar

Knox, C. K. (1973). Characteristics of inflation and deflation reflexes during expiration in the cat. J. Neurophysiol. 36, 284–95.Google Scholar

Krogh, A. & Lindhard, J. (1913). On the average composition of the alveolar air and its variations during the respiratory cycle. J. Physiol., Lond. 47, 431–45.CrossRefGoogle Scholar

Kronenberg, R., Hamilton, F. N., Gabel, R., Hichkey, R., Read, D. J. C. & Severinghaus, J. W. (1972). Comparison of three methods for quantitating response to hypoxia in man. Resp. Physiol. 16, 109–24.Google Scholar

Lambertsen, C. J., Gelfand, R. & Kemp, R. A. (1965). Dynamic response characteristics of several CO₂-reactive components of the respiratory control system. Cerebrospinal Fluid and the Regulation of Ventilation (ed. Brooks, C. McC., Kao, F. F. and Lloyd, B. B.), pp. 211–40. Oxford: Blackwell.Google Scholar

Lambertsen, C. J., Hall, P., Wollman, H. & Goodman, M. W. (1963). Quantitative interactions of increased Po₂ and Pco₂ upon respiration in man. Ann. N.Y. Acad. Sci. 109, 731–41.Google Scholar

Lee, K. D., Mayou, R. A. & Torrance, R. W. (1964). The effect of blood pressure upon chemoreceptor discharge to hypoxia, and the modification of this effect by the sympathetic-adrenal system. Q. Jl exp. Physiol. 49, 171–83.Google Scholar

Lefrançois, R. & Dajours, P. (1964). Étude des relations entre stimulus ventilatoire gaz carbonique et stimulus ventilatoires neurogéniques de l'exercice musculaire chez l'homme. Revue fr. Étud. clin. biol. 9, 498–505.Google Scholar

Leigh, J. (1972). Evaluation of a two-breath CO₂ test as a measure of arterial chemoreflex sensitivity to CO₂ in man. J. Physiol., Lond. 224, 28P.Google Scholar

Leitner, L.-M., Pàges, B., Puccinelli, R. & Dejours, P. (1965). Étude simultanée de la ventilation et des décharges des chémorécepteurs du glomus carotidien chez le Chat. II. Au cours d'inhalations bréves d'anhydride carbonique. Archs int. Pharmacodyn. Ther. 154, 427–433.Google Scholar

Leusen, I. (1954). Chemosensitivity of the respiratory center. Influence of CO₂ in the cerebral ventricles on respiration. Am. J. Physiol. 176, 39–44.CrossRefGoogle ScholarPubMed

Leusen, I., Demeester, G. & Lacroix, E. (1967). Lactate and pyruvate in the brain of rats during changes in acid-base balance. Archs Int. Physiol. Biochim. 75, 310–24.Google ScholarPubMed

Lipscomb, W. T. & Boyarsky, L. L. (1972). Neurophysiological investigations of medullary chemosensitive areas of respiration. Resp. Physiol. 16, 362–76.CrossRefGoogle ScholarPubMed

Lloyd, B. B. (1966). The interactions between hypoxia and other ventilatory stimuli. Proc. int. Symp. cardiovasc. respir. Effects Hypoxia (ed. Hatcher, J. D. and Jennings, D. B.), pp. 146–65. Basel: Karger.Google Scholar

Lloyd, B. B. & Cunningham, D. J. C. (1963). Quantitative approach to the regulation of human respiration. In The Regulation of Human Respiration (ed. Cunningham, D. J. C. and Lloyd, B. B.), pp. 331–49. Oxford: Blackwell.Google Scholar

Lloyd, B. B., Jukes, M. G. M. & Cunningham, D. J. C. (1958). The relation between alveolar oxygen pressure and the respiratory response to carbon dioxide in man. Q. Jl exp. Physiol. 43, 214–27.CrossRefGoogle ScholarPubMed

Loeschcke, H. H. (1965). A concept of the role of intracranial chemosensitivity in respiratory control. Cerebrospinal Fluid and the Regulation of Ventilation (ed. Brooks, C. McC., Kao, F. F. and Lloyd, B. B.), pp. 183–207. Oxford: Blackwell.Google Scholar

Loeschcke, H. H. & Gertz, K. H. (1958). Einfluss des O₂-Druckes in der Einatmungsluft auf die Atemtätigkeit des Menschen, geprüft unter Konstanthaltung des alveolaren CO₂-Druckes. Pflügers Arch. ges. Physiol. 267, 460–77.CrossRefGoogle Scholar

Loeschcke, H. H., Koepchen, H. P. & Gertz, K. H. (1958). Über den Einfluss von Wasserstoffionenkonzentration und CO₂-Druck im Liquor cerebrospinalis auf die Atmung. Pflügers Arch. ges. Physiol. 266, 569–85.Google Scholar

Loeschcke, H. H. & Mitchell, R. A. (1963). Properties and localisation of intracranial chemosensitivity. In The Regulation of Human Respiration (ed. Cunningham, D. J. C. and Lloyd, B. B.), pp. 243–56. Oxford: Blackwell.Google Scholar

Lugliani, R., Whipp, B. J., Seard, C. & Wasserman, K. (1971). Effects of bilateral carotid body resection on ventilatory control at rest and during exercise in man. New Engl. J. Med. 285, 1105–11.Google Scholar

McCloskey, D. I. (1968). Carbon dioxide and the carotid body. In Arterial Chemoreceptors (ed. Torrance, R. W.), pp. 279–92. Oxford: Blackwell.Google Scholar

McCloskey, D. I. & Mitchell, J. H. (1972). Reflex cardiovascular and respiratory responses originating in exercising muscle. J. Physiol., Lond. 224, 173–86.Google Scholar

Majcherczyk, S. & Willshaw, P. (1973). Inhibition of peripheral chemoreceptor activity during superfusion with an alkaline c.s.f. of the ventral brainstem surface of the cat. J. Physiol., Lond. 231, 26P.Google ScholarPubMed

Marsh, R. H. K., Lyen, K. R., McPherson, G. A. D., Pearson, S. B. & Cunningham, D. J. C. (1973). Breath-by-breath effects of imposed alternate-breath oscillations of alveolar CO₂. Resp. Physiol. 18, 80–91.Google Scholar

Matell, G. (1963). Time-courses of changes in ventilation and arterial gas tensions in man induced by moderate exercise. Acta physiol. scand. 58, Suppl. 206.Google Scholar

Miescher-Rüsch, F. (1885). Bemerkungen zur Lehre von den Athembewegungen. Arch. Anat. Physiol. 355–80.Google Scholar

Milhorn, H. T. (1966). The Application of Control Theory to Physiological Systems. Philadelphia: W. B. Saunders.Google Scholar

Milhorn, H. R. & Guyton, A. C. (1965). An analog computer analysis of Cheyne–Stokes breathing. J. appl. Physiol. 20, 328–33.Google Scholar

Miller, J. P., Cunningham, D. J. C., Lloyd, B. B. & Young, J. M. (1974). The transient respiratory effects in man of sudden changes in alveolar CO₂ in hypoxia and in high oxygen. Resp. Physiol. (in the Press).CrossRefGoogle Scholar

Mills, E. & Jöbsis, F. F. (1970). Simultaneous measurement of cytochrome a ₃ reduction and chemoreceptor afferent activity in the carotid body. Nature, Lond. 225, 1147–9.Google Scholar

Mitchell, R. A. (1965). The regulation of respiration in metabolic acidosis and alkalosis. In Cerebrospinal Fluid and the Regulation of Ventilation (ed. Brooks, C. McC.Kao, F. F. and Lloyd, B. B.), pp. 109–31. Oxford: Blackwell.Google Scholar

Mitchell, R. A., Bainton, C. R. & Edelist, G. (1966). Posthyperventilation apnea in awake dogs during metabolic acidosis and hypoxia. J. appl. Physiol. 21, 1363–7.CrossRefGoogle ScholarPubMed

Mitchell, R. A., Loeschcke, H. H., Massion, W. H. & Severinghaus, J. W. (1963). Respiratory responses mediated through superficial chemosensitive areas on the medulla. J. appl. Physiol. 18, 523–33.CrossRefGoogle ScholarPubMed

Myhre, K. & Lange, Andersen K. (1971). Respiratory responses to static muscular work. Resp. Physiol. 12, 77–89.Google Scholar

Neil, E. (1963). Discussion. In The Regulation of Human Respiration, (ed. Cunningham, D. J. C. and Lloyd, B. B.), p. 201. Oxford: Blackwell.Google Scholar

Neil, E. & O'Regan, R. G. (1971). Efferent and afferent impulse activity recorded from few-fibre preparations of otherwise intact sinus and aortic nerves. J. Physiol. 215, 33–47.Google Scholar

Nielsen, M. (1936). Untersuchungen über die Atemregulation beim Menschen, besonders mit Hinblick auf die Art des chemischen Reizes. Skand. Arch. Physiol. 74, Suppl. 10, 87–208.Google Scholar

Nielsen, M. & Smith, H. (1952). Studies on the regulation of respiration in acute hypoxia. Acta physiol. stand. 24, 293–313.Google Scholar

Pappenheimer, J. R., Fencl, V., Heisey, S. R. & Held, D. (1965). Role of cerebral fluids in control of respiration as studied in unanesthetized goats. Am. Jl Physiol. 208, 436–50.Google Scholar

Pearson, S. B. & Cunningham, D. J. C. (1973). Some observations on the relation between ventilation, tidal volume and frequency in man in various steady and transient states. Acta Neurobiol. exper. 33, 177–88.Google Scholar

Perkins, J. F., Buchthal, A., Domizi, D. B., Schafer, J. & Shapiro, S. (1966). Lack of influence of changes in arterial P _co2, on ventilatory response to a constant stimulus to the carotid bodies. Fedn Proc. Fedn Am. Socs exp. Biol. 25, 389.Google Scholar

Purves, M. J. (1966 a). Fluctuations of arterial oxygen tension which have the same period as respiration. Resp. Physiol. 1, 281–96.Google Scholar

Purves, M. J. (1966 b). The effect of eliminating fluctuations of gas tensions in arterial blood on carotid chemoreceptor activity and respiration. J. Physiol., Lond. 186, 63P.Google Scholar

Rahn, H. (1955). Permanent residents at altitude within the United States. Studies in Respiratory Physiology, 2nd ser. WADC Technical Report 55–357.Google Scholar

Raub, W. F. (1965). Doctoral dissertation, University of Pennsylvania. Cited by Edwards, M. W. and Yamamoto, W. S., in Physiological Controls and Regulation (ed. Yamamoto, W. S. and Brobeck, J. R.), pp. 158–80. Philadelphia: W. B. Saunders.Google Scholar

Riedstra, J. W. (1963). Influence of central and peripheral P _co2 (pH) on the ventilatory response to hypoxic chemoreceptor stimulation. Acta physiol. pharmacol. neerl. 12, 407–52.Google Scholar

Schläfke, M. E., See, W. R. & Loeschcke, H. H. (1970). Ventilatory response to alterations of H⁺ ion concentration in small areas of the ventral medullary surface. Resp. Physiol. 10, 198–212.Google Scholar

Severinghaus, J. W. (1972). Hypoxic respiratory drive and its loss during chronic hypoxia. Clin. Physiol. 2, 57–79.Google Scholar

Sørensen, S. C. (1971). The chemical control of ventilation. Acta physiol. scand. 82, Suppl. 361.Google Scholar

Sørensen, S. C. & Cruz, J. C. (1969). Ventilatory response to a single breath of CO₂ in O₂ in normal man at sea level and high altitude. J. appl. Physiol. 27, 186–90.CrossRefGoogle Scholar

Torrance, R. W. (1968) Prolegomena. Arterial Chemoreceptors (ed. Torrance, R. W.). Oxford: Blackwell.Google Scholar

Torrance, R. W. (1974). Arterial chemoreceptors. In International Review of Science, Section I, Physiology (ed. Guyton, A. C.); vol. II, Respiration (ed. Widdicombe, J. G.), pp. 247–70. Lancaster: Medical and Technical Publishing.Google Scholar

Wade, J. G., Larson, C. P., Hickey, R. F., Ehrenfeld, W. K. & Severinghaus, J. W. (1970). Effect of carotid endarterectomy on carotid chemoreceptor and baroreceptor function. New Engl. J. Med. 282, 823–9.Google Scholar

Ward, S. A., Howson, M. G., Petersen, E.Strange & Cunningham, D. J. C. (1974). (In preparation.)Google Scholar

Well, J. V., Byrne-Quinn, E., Sodal, I. E., Kline, J. S., McCullough, R. E. & Filley, G. F. (1972). Augmentation of chemosensitivity during mild exercise in normal man. J. appl. Physiol. 33, 813–19.CrossRefGoogle Scholar

Wiemer, W., Winterstein, H., Kiwull, P., Ott, N. (1965). Interaction of intracranial and extracranial respiratory mechanisms. In Cerebrospinal Fluid and the Regulation of Ventilation (ed. Brooks, C. McC., Kao, F. F. and Lloyd, B. B.), pp. 303–21. Oxford: Blackwell.Google Scholar

Yamamoto, W. S. (1960). Mathematical analysis of the time course of alveolar CO₂. J. appl. Physiol. 15, 215–19.Google Scholar

Yamamoto, W. S. & Edwards, McI. W. (1960). Homeostasis of carbon dioxide during intravenous infusion of carbon dioxide. J. appl. Physiol. 15, 807–18.Google Scholar

Young, J. M. (1970). Some factors affecting respiration in man. D. Phil. Thesis, Oxford University.Google Scholar