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Vagus nerve stimulation for treatment of epilepsy in Rett syndrome

Published online by Cambridge University Press:  12 July 2006

Angus A Wilfong
Affiliation:
Baylor College of Medicine, Pediatric Neurology, Houston, Texas, USA.
Rebecca J Schultz
Affiliation:
Baylor College of Medicine, Pediatric Neurology, Houston, Texas, USA.
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Abstract

This case series presents the outcomes of seven females with Rett syndrome and medically refractory epilepsy who were treated with adjunctive vagus nerve stimulation (VNS) therapy for a minimum of 12 months. Patients ranged in age from 1 to 14 years (median age 9y) at the time of implantation, had experienced seizures for a median period of approximately 6 years, and had failed at least two trials of antiepileptic drugs before receiving VNS. The median number of seizures per month was 150 (range 12–3600). At 12 months, six females had [ges ]50% reduction in seizure frequency. VNS was safe and well tolerated, with no surgical complications and no patients requiring explantation of the device. Quality of life outcomes of note among these patients included reports at 12 months of increased alertness among all seven patients. No change in mood or communication abilities was noted.

Type
Original Articles
Copyright
2006 Mac Keith Press

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