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Apolipoprotein E polymorphism and changes in serum lipids during a family-based counselling intervention

Published online by Cambridge University Press:  02 January 2007

Marika Salminen ,
Terh Lehtimäki ,
Yue-Mei Fan ,
Tero Vahlberg  and
Sirkka-Liisa Kivelä
Marika Salminen*
Affiliation:
Institute of Clinical Medicine, Family Medicine, Lemminkäisenkatu 1, FI-20014 University of Turku, Turku, Finland Härkätie Health Centre, Lieto, Finland
Terh Lehtimäki
Affiliation:
Laboratory of Atherosclerosis Genetics, Department of Clinical Chemistry, Centre for Laboratory Medicine, Tampere University Hospital and University of Tampere Medical School, Tampere, Finland
Yue-Mei Fan
Affiliation:
Laboratory of Atherosclerosis Genetics, Department of Clinical Chemistry, Centre for Laboratory Medicine, Tampere University Hospital and University of Tampere Medical School, Tampere, Finland
Tero Vahlberg
Affiliation:
Institute of Clinical Medicine, Biostatistics, University of Turku, Turku, Finland
Sirkka-Liisa Kivelä
Affiliation:
Institute of Clinical Medicine, Family Medicine, Lemminkäisenkatu 1, FI-20014 University of Turku, Turku, Finland Satakunta Central Hospital, Pori, Finland Unit of Family Medicine, Turku University Hospital, Turku, Finland
*
*corresponding author: Email majosa@utu.fi
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Abstract

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Objective

To compare serum lipids and their changes during a family-based health education in children aged 6–17 years with or without the ɛ4 allele of the gene encoding apolipoprotein E (apoE).

Design

An intervention study.

Setting

A family-based prevention of risk factors of coronary heart disease in Eastern Finland. The programme consisted of two counselling meetings at children's schools and three at children's homes.

Subjects

Four hundred and thirty-nine children with a family history of cardiovascular diseases (CVD) participated in a family-based health education. The children were divided into two groups according to apoE genotype. The risk group consisted of 143 children having apoE ɛ4 allele (genotype ɛ3/4 or ɛ4/4) and the non-risk group of 296 children without apoE ɛ4 allele (ɛ2/3 or ɛ3/3). The final sample of the follow-up study included 354 (81%) children (114 and 240, respectively).

Results

Baseline differences were found in low-density lipoprotein cholesterol (LDL-C) (P = 0.007) and LDL-C/high-density lipoprotein cholesterol (HDL-C) ratio (P = 0.030) among boys and in total cholesterol (TC)/HDL-C (P = 0.008) and LDL-C/HDL-C ratios (P = 0.006) among girls. Differences between groups in changes during the follow-up were observed only for TC/HDL-C ratio (P-value adjusted for age = 0.049) among boys.

Conclusions

At baseline, children with apoE ɛ4 allele had on average a more unfavourable lipid profile than those without apoE ɛ4 allele. However, the effect of about 33 months' family-based health education on plasma lipids did not depend on apoE genotype in children with a family history of CVD.

Keywords

Apolipoprotein ECholesterolChildrenDietIntervention
Type
Research Article
Information
Public Health Nutrition , Volume 9 , Issue 7 , October 2006 , pp. 859 - 865
Copyright
Copyright © The Authors 2006

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