How does drug abuse interact with familial and developmental factors in the etiology of schizophrenia?

Chih-Ken Chen; Robin M. Murray

doi:10.1017/CBO9780511735103.016

14 - How does drug abuse interact with familial and developmental factors in the etiology of schizophrenia?

Published online by Cambridge University Press: 04 August 2010

Chih-Ken Chen and

Robin M. Murray

Edited by

Matcheri S. Keshavan ,

James L. Kennedy and

Robin M. Murray

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Chih-Ken Chen: Affiliation:
Chang Gung Memorial Hospital, Keelung, Taiwan
Robin M. Murray: Affiliation:
Institute of Psychiatry, King's College, London, UK
Matcheri S. Keshavan: Affiliation:
University of Pittsburgh
James L. Kennedy: Affiliation:
Clarke Institute of Psychiatry, Toronto
Robin M. Murray: Affiliation:
Institute of Psychiatry, London

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Summary

The environmental risk factors for schizophrenia can be summarized as operating either early in life or later nearer the onset of frank psychosis. This chapter focuses on the role of drug abuse as one of the later factors, and on how it interacts with familial and developmental factors. All the molecular genetic study results discussed are preliminary; both the positive and the negative findings need replication in larger samples. It is likely that certain drugs change the expressions of genes related to neurotransmitter systems such as dopamine or glutamic acid and also for transcription factors, cell proliferation, apoptosis, cell adhesion, and the synapse. Recent research suggests that dopamine sensitization may underlie both craving and the onset of drug-associated psychosis. A drug abuser with low liability to psychosis may use psychostimulant drugs regularly for longer periods without developing psychosis or, at worst may have just brief psychotic symptoms.

Keywords

dopamine sensitization drug abuse molecular genetic study schizophrenia psychosis

Type: Chapter
Information: Neurodevelopment and Schizophrenia , pp. 248 - 270

DOI: https://doi.org/10.1017/CBO9780511735103.016 [Opens in a new window]

Publisher: Cambridge University Press

Print publication year: 2004

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