Current Biology
Volume 7, Issue 12, 1 December 1997, Pages R745-R749
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Recombination initiation: Easy as A, B, C, D… χ?

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Abstract

The octameric Chi (χ) sequence is a recombination hotspot in Escherichia coli. Recent studies suggest a singular mechanism by which χ regulates not only the nuclease activity of RecBCD enzyme, but also the ability of RecBCD to promote loading of the strand exchange protein, RecA, onto χ-containing DNA.

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AK Eggleston and SC West, Imperial Cancer Research Fund, Clare Hall Laboratories, South Mimms, Potters Bar, Hertfordshire EN6 3LD, UK.