The discovery of non-basic atrial natriuretic peptide clearance receptor antagonists. part 1
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Cited by (30)
Developmental roles of natriuretic peptides and their receptors
2023, Cells and DevelopmentModified synthesis of the peptidomimetic natriuretic peptide receptor-C antagonist M372049
2020, Tetrahedron LettersCitation Excerpt :A possible alternative approach to the treatment of hypertension and other related cardiovascular disorders would be to inhibit NPR-C and increase the concentration of circulating NPs. This approach was reported by investigators at AstraZeneca [5], and the peptidomimetic M372049 (1) is presently considered to be the best-in-class NPR-C antagonist. However, its lack of commercial availability has precluded its use as a tool compound to support in vivo cardiovascular studies.
Osteocrin is a specific ligand of the natriuretic peptide clearance receptor that modulates bone growth
2007, Journal of Biological ChemistryCitation Excerpt :The most consistent homology between species for Ostn lies in the C-terminal region of the protein, and it is this region that displays homology to the NPs. Most interestingly, the best conserved homology with the NPs includes the residues Phe7, Gly8, and Arg13 (numbering according to CNP) that have been demonstrated to be necessary for peptide binding to the NPR-C receptor (26-28). Furthermore, the lack of the two cysteine residues present in all NPs indicates Ostn does not form the cyclic ring structure that is essential for binding to the receptors signaling through cGMP, GC-A, and GC-B (29, 30).
Dendroaspis natriuretic peptide binds to the natriuretic peptide clearance receptor
2007, Biochemical and Biophysical Research CommunicationsCitation Excerpt :For competition experiments, [125I]-ANP(3–28) was used for NPR-C and GC-A, and [125I]-CNP was used for GC-B experiments. In membranes from CHO-K1 cells expressing human recombinant GC-A receptor, the endogenous natriuretic peptide ANP displaced bound radioligand with characteristic potency (Fig. 1), while GC-B-selective CNP and the NPR-C-selective ligand AP-811 [16] did not displace [125I]-ANP(3–28) (Fig. 1). DNP displaced [125I]-ANP(3–28) with a Ki of 100 pmol l−1 (Fig. 1).
C-type natriuretic peptide: a new endothelium-derived hyperpolarizing factor?
2007, Trends in Pharmacological Sciences