Elsevier

Mechanisms of Development

Volume 89, Issues 1–2, 1 December 1999, Pages 179-183
Mechanisms of Development

Gene expression pattern
Expression of Frzb-1 during chick development

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Abstract

We cloned the chick homolog of Xenopus and mouse Frzb-1, a secreted Wnt antagonist and performed in situ hybridisations to determine the pattern of cFrzb-1 expression in the developing chick embryo. At early stages, cFrzb-1 transcripts are located exclusively in the ectodermal layer corresponding to the neural plate. The labelling continues in the neural tube, but is always excluded from the floor plate. cFrzb-1 mRNA is expressed by migrating cephalic and truncal neural crest cells. Later, cFrzb-1 transcripts are found in a subset of neural crest derivatives such as cephalic cartilage, nerves and spinal ganglia. In addition to ectodermal derivatives, cFrzb-1 transcripts were also observed in mesodermal derivatives such as vertebral and limb cartilage, the adrenal cortex, the gonads, and a subpopulation of blood cells.

Keywords

Frzb-1
Wnt antagonist
Chick embryo
Neurulation
Neural crest
Cartilage

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1

Present address: Department of Biology, Free University of Brussels (VUB) – Pleinlaan, 2-1050 Brussels, Belgium.