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Animal models of acute ischaemic stroke: can they predict clinically successful neuroprotective drugs?

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Abstract

Substantial efforts are being made to develop drugs which will protect the brain from the neurodegeneration that follows an acute ischaemic stroke. However, while there are already a significant number of animal models of stroke, there is currently no information as to whether activity of a compound in any of them will predict clinical efficacy. In this article, Jackie Hunter, Richard Green and Alan Cross review the major models of acute cerebral ischaemia and propose rational protocols for examining novel neuroprotective agents.

References (60)

  • R. Bonita

    Lancet

    (1992)
  • L.R. Caplan

    Lancet

    (1992)
  • M.G. Marmot et al.

    Lancet

    (1992)
  • B.K. Siesjö

    Prog. Brain Res.

    (1993)
  • W. Pulsinelli

    Lancet

    (1992)
  • T. Kirino

    Brain Res.

    (1982)
  • A.R. Green et al.

    Neurosci. Lett.

    (1994)
  • M.F. Snape et al.

    Neuroscience

    (1993)
  • C.D. Benham

    Neuropharmacology

    (1993)
  • X. Cao et al.

    Brain Res.

    (1994)
  • M.J. Robinson et al.

    Neurosci. Lett.

    (1990)
  • P.M. Patel et al.

    Surg. Neurol.

    (1991)
  • M. Nedergaard

    Brain Res.

    (1987)
  • C.K. Park et al.

    Neurosci. Lett.

    (1992)
  • R.H. Hatfield et al.

    Eur. J. Pharmacol.

    (1992)
  • R. Gill et al.

    Eur. J. Pharmacol.

    (1990)
  • A.R. Green et al.

    Prog. Neurobiol.

    (1994)
  • J. Bamford

    Lancet

    (1992)
  • D.L. Rogers

    Behav. Brain Res.

    (1992)
  • J. Benavides et al.

    Neurosci. Lett.

    (1990)
  • F.C. Barone

    Brain Res.

    (1993)
  • R.H. Hatfield et al.

    Brain Res.

    (1992)
  • Who Monica Project

    J. Clin. Epidemiol.

    (1988)
  • Stroke

    (1992)
  • N.S. Abramson

    New Engl. J. Med.

    (1986)
  • D.O. Wiebers et al.

    Stroke

    (1990)
  • G.F. Molinari

    Stroke

    (1988)
  • S.E. Karpiak et al.

    Annu. Rev. Pharmacol. Toxicol.

    (1989)
  • C. Millikan

    Stroke

    (1992)
  • I.M. Macrae

    Br. J. Clin. Pharmacol.

    (1992)
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