Deregulation of cyclooxygenase and nitric oxide synthase gene expression in the inflammatory cascade triggered by experimental group B streptococcal meningitis in the newborn brain and cerebral microvessels
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Cited by (20)
Group B streptococci and inducible nitric oxide synthase: Modulation by nuclear factor kappa B and ibuprofen
2001, Seminars in PerinatologyEffects of nitric oxide donors on the afferent resting activity in the cephalopod statocyst
2000, Brain ResearchCitation Excerpt :PG receptors were found in the vestibular nucleus [62] and PG is essential for the normal development of the vestibular end organs [70]; PG-E1 therapy may even prevent malfunction of the inner ear caused by microcirculatory disorders [22,65]. The key enzyme in prostaglandin biosynthesis, cyclooxygenase, may be directly activated by NO [21,33], leading to the production of physiologically relevant quantities of PGE2[36]. The biosynthesis of PGE2, which down-regulates LPS-induced iNOS expression [37,50], may be a mechanism by which inflammatory macrophages protect themselves against the cytotoxic effects of NO [73].
Group B Streptococcal Neonatal Meningitis
2022, Clinical Microbiology Reviews
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